SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4es9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
4es9 EPF
(Streptococcus
pyogenes)
5 / 11 VAL A 251
ALA A 191
GLU A 187
SER A 192
ARG A 216
None
1.39A 3kp5A-4es9A:
undetectable
3kp5A-4es9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)
4es9 EPF
(Streptococcus
pyogenes)
4 / 5 GLY A 278
ASP A 277
ARG A 279
MET A 223
None
1.36A 3qx3A-4es9A:
undetectable
3qx3A-4es9A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)
4es9 EPF
(Streptococcus
pyogenes)
4 / 5 GLY A 278
ASP A 277
ARG A 279
MET A 223
None
1.31A 3qx3B-4es9A:
undetectable
3qx3B-4es9A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)
4es9 EPF
(Streptococcus
pyogenes)
5 / 7 LEU A 145
ILE A 153
VAL A 226
LEU A 225
SER A 224
None
1.01A 3r9vA-4es9A:
undetectable
3r9vB-4es9A:
undetectable
3r9vA-4es9A:
23.01
3r9vB-4es9A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
4es9 EPF
(Streptococcus
pyogenes)
3 / 3 LEU A 225
MET A 223
ASP A 186
None
0.73A 3v5wA-4es9A:
undetectable
3v5wA-4es9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)
4es9 EPF
(Streptococcus
pyogenes)
4 / 5 THR A 165
ILE A 164
LYS A 230
PHE A 243
None
1.49A 4acaC-4es9A:
undetectable
4acaC-4es9A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)
4es9 EPF
(Streptococcus
pyogenes)
3 / 3 ARG A  79
ARG A 105
TRP A  69
None
1.39A 4b7nA-4es9A:
undetectable
4b7nA-4es9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)
4es9 EPF
(Streptococcus
pyogenes)
3 / 3 ARG A  79
ARG A 105
TRP A  69
None
1.44A 4cpzC-4es9A:
undetectable
4cpzC-4es9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)
4es9 EPF
(Streptococcus
pyogenes)
3 / 3 ARG A  79
ARG A 105
TRP A  69
None
1.41A 4cpzE-4es9A:
undetectable
4cpzE-4es9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)
4es9 EPF
(Streptococcus
pyogenes)
3 / 3 ARG A  79
ARG A 105
TRP A  69
None
1.36A 4cpzF-4es9A:
undetectable
4cpzF-4es9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)
4es9 EPF
(Streptococcus
pyogenes)
3 / 3 ARG A  79
ARG A 105
TRP A  69
None
1.36A 4cpzG-4es9A:
undetectable
4cpzG-4es9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)
4es9 EPF
(Streptococcus
pyogenes)
3 / 3 ARG A  79
ARG A 105
TRP A  69
None
1.42A 4cpzH-4es9A:
undetectable
4cpzH-4es9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
4es9 EPF
(Streptococcus
pyogenes)
5 / 12 PRO A 133
GLY A  84
ASP A 240
ALA A 124
ARG A 125
None
1.31A 5zvgB-4es9A:
undetectable
5zvgB-4es9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
4es9 EPF
(Streptococcus
pyogenes)
5 / 12 TYR A 151
LEU A  62
ILE A 146
THR A 301
THR A 252
None
1.24A 6djzB-4es9A:
undetectable
6djzB-4es9A:
21.12