SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4esa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 202 (-4.1A)
None
HEM  B 202 (-3.9A)
HEM  B 202 (-3.3A)
 0.91A 1lh6A-4esaB:
13.9		 1lh6A-4esaB:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4esa HEMOGLOBIN ALPHA
CHAIN
(Eleginops
maclovinus) 		4 / 5 LYS A  73
LEU A  81
MET A  64
LEU A  13
 None
 1.46A 1skxA-4esaA:
undetectable		 1skxA-4esaA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		5 / 9 LEU B  68
LEU B 110
VAL B 137
ALA B 140
LEU B  88
 None
None
None
None
HEM  B 202 (-4.7A)
 1.12A 1tbfA-4esaB:
undetectable		 1tbfA-4esaB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		5 / 12 LEU B  71
PHE B 122
MET B 118
SER B  17
PHE B  15
 HEM  B 202 ( 4.7A)
None
None
None
None
 1.47A 1xomA-4esaB:
undetectable		 1xomA-4esaB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		5 / 12 LEU B  71
PHE B 122
MET B 118
SER B  17
PHE B  15
 HEM  B 202 ( 4.7A)
None
None
None
None
 1.50A 1xomB-4esaB:
undetectable		 1xomB-4esaB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4esa HEMOGLOBIN ALPHA
CHAIN
(Eleginops
maclovinus) 		4 / 8 ILE A  24
LEU A  13
VAL A  10
LEU A 126
 None
 0.90A 2w98B-4esaA:
undetectable		 2w98B-4esaA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		4 / 8 VAL B  60
HIS B  41
THR B  38
VAL B  98
 None
HEM  B 202 (-4.4A)
HEM  B 202 (-3.8A)
HEM  B 202 ( 4.6A)
 1.15A 3fhxB-4esaB:
undetectable		 3fhxB-4esaB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		5 / 9 LEU B 110
VAL B  67
TYR B  20
GLY B  64
LEU B  18
 None
HEM  B 202 (-3.9A)
None
None
None
 1.39A 3lp0A-4esaB:
undetectable		 3lp0A-4esaB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4esa HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus;
Eleginops
maclovinus) 		3 / 3 ASP A  27
ASN A  26
SER B 120
 None
 0.82A 3lslA-4esaA:
undetectable
3lslD-4esaA:
undetectable		 3lslA-4esaA:
20.62
3lslD-4esaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4esa HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus;
Eleginops
maclovinus) 		3 / 3 SER B 120
ASP A  27
ASN A  26
 None
 0.88A 3lslA-4esaB:
undetectable
3lslD-4esaB:
undetectable		 3lslA-4esaB:
21.43
3lslD-4esaB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		4 / 7 PHE B  15
GLY B  70
ILE B  81
PHE B 133
 None
HEM  B 202 ( 4.2A)
None
None
 0.83A 4ejjA-4esaB:
undetectable		 4ejjA-4esaB:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 4esa HEMOGLOBIN ALPHA
CHAIN
(Eleginops
maclovinus) 		4 / 5 SER A 103
LYS A 100
LEU A 130
ASP A 127
 HEM  A 202 ( 4.7A)
None
None
None
 1.47A 4ifxA-4esaA:
undetectable		 4ifxA-4esaA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4esa HEMOGLOBIN ALPHA
CHAIN
(Eleginops
maclovinus) 		4 / 5 SER A 103
LYS A 100
LEU A 130
ASP A 127
 HEM  A 202 ( 4.7A)
None
None
None
 1.44A 4ig1A-4esaA:
undetectable		 4ig1A-4esaA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		4 / 8 PHE B  42
SER B  44
ALA B  62
PHE B 133
 HEM  B 202 (-4.1A)
HEM  B 202 ( 4.7A)
None
None
 1.03A 4rkuA-4esaB:
undetectable
4rkuJ-4esaB:
undetectable		 4rkuA-4esaB:
12.00
4rkuJ-4esaB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4esa HEMOGLOBIN ALPHA
CHAIN
(Eleginops
maclovinus) 		4 / 5 SER A 103
LYS A 100
LEU A 130
ASP A 127
 HEM  A 202 ( 4.7A)
None
None
None
 1.47A 4xdtA-4esaA:
undetectable		 4xdtA-4esaA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4esa HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		4 / 8 ARG A  31
GLY B 125
GLN B 127
THR B 129
 None
 1.08A 5syjA-4esaA:
undetectable		 5syjA-4esaA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		5 / 12 VAL B  67
PHE B 133
VAL B 114
LEU B 134
VAL B 137
 HEM  B 202 (-3.9A)
None
None
None
None
 1.15A 5tudD-4esaB:
undetectable		 5tudD-4esaB:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		4 / 6 PRO B 124
GLY B 125
THR B 126
LYS B 132
 None
 0.43A 5xxiA-4esaB:
undetectable		 5xxiA-4esaB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4esa HEMOGLOBIN ALPHA
CHAIN
(Eleginops
maclovinus) 		3 / 3 LYS A  11
LEU A  77
ASP A  75
 None
 0.91A 5zv2A-4esaA:
undetectable		 5zv2A-4esaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4esa HEMOGLOBIN BETA
CHAIN
(Eleginops
maclovinus) 		4 / 6 ILE B  81
MET B  78
ASN B  77
ASP B  79
 None
 1.50A 6dhbA-4esaB:
undetectable		 6dhbA-4esaB:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4esa HEMOGLOBIN ALPHA
CHAIN
(Eleginops
maclovinus) 		3 / 3 ASP A  95
SER A 134
SER A 138
 None
HEM  A 202 ( 4.3A)
None
 0.79A 6mxtA-4esaA:
undetectable		 6mxtA-4esaA:
15.04