SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ese'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		5 / 12 LEU A 138
LEU A   5
PHE A 109
LEU A 161
ALA A  94
 None
 1.02A 1bzfA-4eseA:
undetectable		 1bzfA-4eseA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		5 / 10 VAL A 172
VAL A  40
VAL A  26
ILE A 177
LEU A 138
 None
 1.13A 1fe2A-4eseA:
undetectable		 1fe2A-4eseA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		4 / 6 LEU A 195
VAL A 198
VAL A   4
VAL A  89
 None
 0.86A 2z97A-4eseA:
undetectable		 2z97A-4eseA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		3 / 3 GLY A 128
GLY A 162
GLY A 165
 None
 0.39A 3bogC-4eseA:
undetectable		 3bogC-4eseA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		3 / 3 GLY A 128
GLY A 162
GLY A 165
 None
 0.30A 3bogD-4eseA:
undetectable		 3bogD-4eseA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		5 / 12 THR A 118
ILE A 137
ALA A  94
LEU A  84
PHE A 160
 None
 1.20A 3vw1B-4eseA:
undetectable		 3vw1B-4eseA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		4 / 7 TYR A 156
VAL A 153
PHE A 109
ILE A  92
 IMD  A 306 ( 4.3A)
IMD  A 306 ( 4.8A)
None
None
 0.80A 3zjqA-4eseA:
undetectable		 3zjqA-4eseA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		4 / 8 LEU A 195
VAL A 198
VAL A   4
VAL A  89
 None
 0.73A 4l4bA-4eseA:
undetectable		 4l4bA-4eseA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		5 / 12 LEU A   7
ILE A  48
ILE A  92
ILE A 112
PHE A 109
 None
 1.24A 4rp8C-4eseA:
undetectable		 4rp8C-4eseA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		5 / 12 ALA A 178
GLY A 180
SER A  15
GLY A 176
LEU A 138
 None
 1.13A 5gwxA-4eseA:
2.4		 5gwxA-4eseA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		5 / 9 ILE A  92
ALA A 135
ILE A  90
ILE A 164
LEU A  84
 None
 0.85A 5mvmA-4eseA:
undetectable
5mvmE-4eseA:
undetectable		 5mvmA-4eseA:
17.88
5mvmE-4eseA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		5 / 10 ILE A 164
LEU A  84
ILE A  92
ALA A 135
ILE A  90
 None
 0.88A 5mvmD-4eseA:
undetectable
5mvmE-4eseA:
undetectable		 5mvmD-4eseA:
17.88
5mvmE-4eseA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		6 / 12 LEU A   5
ALA A 135
ASP A 168
GLY A 165
ILE A 164
ILE A  90
 None
 1.49A 5t2zB-4eseA:
undetectable		 5t2zB-4eseA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4ese FMN-DEPENDENT
NADH-AZOREDUCTASE
(Yersinia
pestis) 		4 / 8 LEU A 195
VAL A 198
VAL A   4
VAL A  89
 None
 0.70A 6cp4A-4eseA:
undetectable		 6cp4A-4eseA:
21.22