SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4esj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4esj TYPE-2 RESTRICTION
ENZYME DPNI
(Streptococcus
pneumoniae) 		5 / 12 ILE A 143
GLY A 140
ILE A 124
GLU A  64
PHE A  96
 None
 1.25A 1sg9A-4esjA:
undetectable		 1sg9A-4esjA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4esj TYPE-2 RESTRICTION
ENZYME DPNI
(Streptococcus
pneumoniae) 		5 / 12 ILE A 236
GLN A 233
ILE A 192
PHE A 117
PHE A 177
 None
 1.10A 1uduB-4esjA:
undetectable		 1uduB-4esjA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4esj TYPE-2 RESTRICTION
ENZYME DPNI
(Streptococcus
pneumoniae) 		5 / 12 ILE A 236
GLN A 233
ILE A 192
PHE A 117
PHE A 177
 None
 1.09A 1xozA-4esjA:
undetectable		 1xozA-4esjA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4esj TYPE-2 RESTRICTION
ENZYME DPNI
(Streptococcus
pneumoniae) 		4 / 5 PHE A 172
SER A 122
PHE A  63
ILE A 123
 None
 1.31A 2v0mD-4esjA:
undetectable		 2v0mD-4esjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4esj TYPE-2 RESTRICTION
ENZYME DPNI
(Streptococcus
pneumoniae) 		4 / 5 GLY A 187
PRO A 114
THR A 119
THR A 189
 None
 1.23A 5h5fA-4esjA:
undetectable		 5h5fA-4esjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4esj TYPE-2 RESTRICTION
ENZYME DPNI
(Streptococcus
pneumoniae) 		5 / 12 ILE A 192
THR A 189
THR A 119
VAL A 118
VAL A  88
 None
 1.30A 6bzoC-4esjA:
undetectable		 6bzoC-4esjA:
11.44