SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4esq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 4esq SERINE/THREONINE
PROTEIN KINASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 521
MET A 470
LEU A 486
GLN A 483
PHE A 534
 None
 1.36A 1aqbA-4esqA:
undetectable		 1aqbA-4esqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4esq SERINE/THREONINE
PROTEIN KINASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 454
VAL A 455
GLN A 614
 None
 0.74A 3of4B-4esqA:
undetectable		 3of4B-4esqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4esq SERINE/THREONINE
PROTEIN KINASE
(Mycobacterium
tuberculosis) 		4 / 7 GLN A 520
GLY A 504
GLN A 483
ASP A 471
 None
None
None
TB  A 703 (-3.1A)
 1.17A 5vlmC-4esqA:
undetectable		 5vlmC-4esqA:
19.61