SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4esw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		4 / 4 ILE A 224
LEU A 221
VAL A 217
ALA A 211
 None
 0.93A 1mz9A-4eswA:
undetectable		 1mz9A-4eswA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		4 / 6 LEU A  83
ASN A  11
LEU A  10
PHE A   8
 None
 1.44A 1ru9H-4eswA:
undetectable
1ru9L-4eswA:
undetectable		 1ru9H-4eswA:
19.40
1ru9L-4eswA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		4 / 6 LEU A  83
ASN A  11
LEU A  10
PHE A   8
 None
 1.45A 1rukH-4eswA:
undetectable
1rukL-4eswA:
undetectable		 1rukH-4eswA:
19.40
1rukL-4eswA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		5 / 10 GLY A 142
ILE A 163
GLY A 159
ILE A 158
ALA A  63
 None
None
None
None
CIT  A 900 (-3.1A)
 1.01A 1sh9B-4eswA:
undetectable		 1sh9B-4eswA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		3 / 3 ASP A 312
GLU A  86
ARG A 277
 None
 0.76A 1wopA-4eswA:
undetectable		 1wopA-4eswA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		3 / 3 GLN A 324
HIS A 323
ARG A 335
 None
 0.97A 1zlqA-4eswA:
0.0		 1zlqA-4eswA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		5 / 11 LEU A 125
GLU A 192
LEU A 193
GLY A  90
LEU A 185
 None
 1.39A 3hm1B-4eswA:
undetectable		 3hm1B-4eswA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		4 / 5 ASN A  44
GLU A 151
THR A 153
SER A  46
 None
 1.36A 3p2kC-4eswA:
undetectable		 3p2kC-4eswA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		4 / 8 LEU A 193
CYH A 196
GLN A 121
TYR A 282
 None
 1.30A 3po7A-4eswA:
undetectable		 3po7A-4eswA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		3 / 3 THR A   3
ASP A  58
GLU A 212
 None
 0.86A 3qowA-4eswA:
undetectable		 3qowA-4eswA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		5 / 10 ALA A 223
LEU A  35
ILE A  37
ALA A  38
VAL A  57
 None
 1.42A 3r9cA-4eswA:
undetectable		 3r9cA-4eswA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		4 / 6 LEU A 185
ASP A 188
ILE A 149
PRO A  87
 None
 0.99A 4xi3C-4eswA:
undetectable		 4xi3C-4eswA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		3 / 3 THR A   3
ASP A  58
GLU A 212
 None
 0.80A 5fa8A-4eswA:
undetectable		 5fa8A-4eswA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13
(Candida
albicans) 		5 / 12 ILE A  39
TYR A  22
PHE A 220
GLY A  60
LEU A  83
 None
 1.38A 5v5zA-4eswA:
undetectable		 5v5zA-4eswA:
21.68