SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4etp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 695
ASP A 626
ILE A 492
GLY A 490
ILE A 470
 None
MG  A 802 ( 4.1A)
None
None
None
 0.83A 2o4kA-4etpA:
undetectable		 2o4kA-4etpA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 695
ASP A 626
ILE A 492
GLY A 490
ILE A 470
 None
MG  A 802 ( 4.1A)
None
None
None
 0.82A 2qakA-4etpA:
undetectable		 2qakA-4etpA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 582
ARG A 585
ASP A 529
 None
 0.84A 2qe6A-4etpA:
undetectable		 2qe6A-4etpA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 582
ARG A 585
ASP A 529
 None
 0.80A 2qe6B-4etpA:
undetectable		 2qe6B-4etpA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 488
ASP A 489
SER A 494
 None
 0.67A 2qhfA-4etpA:
undetectable		 2qhfA-4etpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 486
ASN A 448
ARG A 392
 None
None
ADP  A 801 (-3.4A)
 0.65A 2rlcA-4etpA:
undetectable		 2rlcA-4etpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		4 / 5 ILE B 461
PHE B 572
VAL B 635
PHE B 424
 None
 1.01A 2ygnA-4etpB:
undetectable		 2ygnA-4etpB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 720
GLY A 657
THR A 694
LEU A 688
THR A 681
 None
 1.34A 3bexA-4etpA:
undetectable
3bexB-4etpA:
undetectable		 3bexA-4etpA:
20.54
3bexB-4etpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 720
GLY A 657
THR A 694
LEU A 688
THR A 681
 None
 1.33A 3bexC-4etpA:
undetectable
3bexD-4etpA:
undetectable		 3bexC-4etpA:
20.54
3bexD-4etpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 11 THR A 694
LEU A 688
THR A 681
VAL A 720
GLY A 657
 None
 1.32A 3bexE-4etpA:
undetectable
3bexF-4etpA:
undetectable		 3bexE-4etpA:
20.54
3bexF-4etpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 11 THR A 694
LEU A 688
THR A 681
VAL A 720
GLY A 657
 None
 1.34A 3bf1C-4etpA:
undetectable
3bf1D-4etpA:
undetectable		 3bf1C-4etpA:
20.54
3bf1D-4etpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 720
GLY A 657
THR A 694
LEU A 688
THR A 681
 None
 1.34A 3bf1E-4etpA:
undetectable
3bf1F-4etpA:
undetectable		 3bf1E-4etpA:
20.54
3bf1F-4etpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 11 THR A 694
LEU A 688
THR A 681
VAL A 720
GLY A 657
 None
 1.32A 3bf1E-4etpA:
undetectable
3bf1F-4etpA:
undetectable		 3bf1E-4etpA:
20.54
3bf1F-4etpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 530
ASP B 529
ILE B 550
GLY B 526
 None
 0.92A 3bufA-4etpB:
undetectable		 3bufA-4etpB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 549
ILE A 560
VAL A 563
PHE A 519
LEU A 684
 None
 1.10A 3em0B-4etpA:
undetectable		 3em0B-4etpA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 467
HIS A 606
ILE A 520
THR A 559
THR A 558
 GOL  A 806 (-3.3A)
GOL  A 804 (-4.0A)
None
None
GOL  A 804 ( 3.8A)
 1.07A 3fw3B-4etpA:
undetectable		 3fw3B-4etpA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		4 / 8 TYR B 408
PHE B 410
ALA B 379
THR B 450
 None
 0.89A 3l4dA-4etpB:
undetectable		 3l4dA-4etpB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 695
ASP A 626
ILE A 492
GLY A 490
ILE A 470
 None
MG  A 802 ( 4.1A)
None
None
None
 0.87A 3oxxC-4etpA:
undetectable		 3oxxC-4etpA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 712
GLU A 709
ARG A 632
 None
 0.82A 3wxoA-4etpA:
undetectable		 3wxoA-4etpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		4 / 7 LEU B 390
VAL B 413
TYR B 408
LEU B 619
 None
 0.92A 4b3qA-4etpB:
undetectable		 4b3qA-4etpB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 522
ALA A 628
LEU A 656
LEU A 684
ILE A 602
 None
 1.09A 4dfrB-4etpA:
undetectable		 4dfrB-4etpA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		3 / 3 ARG B 376
GLU B 370
ASN B 366
 None
 0.90A 4imaD-4etpB:
undetectable		 4imaD-4etpB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 LEU B 322
GLU B 323
LEU A 334
LYS A 331
 None
 1.24A 4k4yA-4etpB:
undetectable		 4k4yA-4etpB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 LEU B 322
GLU B 323
LEU A 334
LYS A 331
 None
 1.23A 4k4yI-4etpB:
undetectable		 4k4yI-4etpB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 410
ILE A 393
ARG A 392
ILE A 700
 GOL  A 803 (-4.0A)
GOL  A 803 ( 4.4A)
ADP  A 801 (-3.4A)
None
 0.82A 4lv9B-4etpA:
undetectable		 4lv9B-4etpA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 711
VAL A 698
LEU A 391
ILE A 700
 None
 0.71A 4r38A-4etpA:
undetectable		 4r38A-4etpA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		4 / 6 GLU B 365
ARG B 412
LEU B 358
ARG B 360
 None
 1.21A 5l6eA-4etpB:
undetectable
5l6eB-4etpB:
undetectable		 5l6eA-4etpB:
20.42
5l6eB-4etpB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		4 / 7 HIS B 416
ASN B 620
HIS B 453
SER B 455
 None
 0.91A 5m8rA-4etpB:
undetectable		 5m8rA-4etpB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		4 / 8 HIS B 416
ASN B 620
HIS B 453
SER B 455
 None
 0.90A 5m8rB-4etpB:
undetectable		 5m8rB-4etpB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		4 / 8 HIS B 416
ASN B 620
HIS B 453
SER B 455
 None
 0.89A 5m8rC-4etpB:
undetectable		 5m8rC-4etpB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		4 / 8 HIS B 416
ASN B 620
HIS B 453
SER B 455
 None
 0.92A 5m8rD-4etpB:
undetectable		 5m8rD-4etpB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 517
VAL A 515
PHE A 603
ILE A 499
 None
 1.01A 5of1A-4etpA:
undetectable		 5of1A-4etpA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 517
VAL A 515
PHE A 603
ILE A 499
 None
 1.04A 5of1B-4etpA:
undetectable		 5of1B-4etpA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4etp KINESIN-LIKE PROTEIN
KAR3
(Saccharomyces
cerevisiae) 		5 / 12 SER A 687
PHE A 471
LEU A 653
LEU A 627
VAL A 625
 GOL  A 805 (-2.8A)
None
None
None
None
 1.06A 5tudA-4etpA:
undetectable		 5tudA-4etpA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 479
LEU B 604
VAL B 603
ILE B 514
ASP B 571
 None
 1.13A 6bxmA-4etpB:
undetectable		 6bxmA-4etpB:
20.81