SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4etz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 191
LEU A 203
ALA A 300
LEU A 267
 None
 1.01A 1cqeA-4etzA:
undetectable		 1cqeA-4etzA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 191
LEU A 203
ALA A 300
LEU A 267
 None
 1.02A 1cqeB-4etzA:
undetectable		 1cqeB-4etzA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4etz PELD
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 188
LEU A 191
ALA A 300
LEU A 267
 None
 0.83A 1pthA-4etzA:
undetectable		 1pthA-4etzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4etz PELD
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 188
LEU A 191
ALA A 300
LEU A 267
 None
 0.83A 1pthB-4etzA:
undetectable		 1pthB-4etzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 191
LEU A 203
ALA A 300
LEU A 267
 None
 1.06A 2aylA-4etzA:
undetectable		 2aylA-4etzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 191
LEU A 203
ALA A 300
LEU A 267
 None
 1.01A 2aylB-4etzA:
undetectable		 2aylB-4etzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4etz PELD
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 404
GLN A 426
LEU A 417
PHE A 407
 None
 1.44A 3ablC-4etzA:
undetectable
3ablJ-4etzA:
undetectable		 3ablC-4etzA:
21.43
3ablJ-4etzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 203
GLY A 202
LEU A 226
LEU A 278
LEU A 192
 None
 1.38A 3cjtK-4etzA:
2.7		 3cjtK-4etzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4etz PELD
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 192
VAL A 265
LEU A 160
ILE A 298
ALA A 297
ALA A 304
 None
 1.50A 3mdvB-4etzA:
undetectable		 3mdvB-4etzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 191
LEU A 203
ALA A 300
LEU A 267
 None
 1.04A 3n8wA-4etzA:
undetectable		 3n8wA-4etzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 191
LEU A 203
ALA A 300
LEU A 267
 None
 0.99A 3n8zA-4etzA:
undetectable		 3n8zA-4etzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 192
GLY A 301
ALA A 304
LEU A 307
 None
 1.10A 3nt1A-4etzA:
undetectable		 3nt1A-4etzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 191
LEU A 203
ALA A 300
LEU A 267
 None
 1.06A 3pghD-4etzA:
undetectable		 3pghD-4etzA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4etz PELD
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 168
TYR A 327
PRO A 389
LEU A 164
 None
 1.22A 3tgvB-4etzA:
undetectable		 3tgvB-4etzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 4etz PELD
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 168
TYR A 327
PRO A 389
LEU A 164
 None
 1.25A 3tgvC-4etzA:
undetectable		 3tgvC-4etzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4etz PELD
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 168
TYR A 327
PRO A 389
LEU A 164
 None
 1.31A 3tgvD-4etzA:
undetectable		 3tgvD-4etzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 11 ARG A 404
LEU A 403
SER A 365
LEU A 384
LEU A 400
 None
 1.48A 4or0A-4etzA:
undetectable		 4or0A-4etzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 303
LEU A 203
LEU A 181
ALA A 185
LEU A 171
 None
 0.99A 4p65E-4etzA:
undetectable
4p65F-4etzA:
undetectable
4p65J-4etzA:
undetectable
4p65L-4etzA:
undetectable		 4p65E-4etzA:
5.99
4p65F-4etzA:
8.12
4p65J-4etzA:
8.12
4p65L-4etzA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 192
GLY A 301
ALA A 304
LEU A 307
 None
 1.15A 4rrwA-4etzA:
undetectable		 4rrwA-4etzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 192
GLY A 301
ALA A 304
LEU A 307
 None
 1.13A 4rrwB-4etzA:
undetectable		 4rrwB-4etzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 192
GLY A 301
ALA A 304
LEU A 307
 None
 1.15A 4rrzA-4etzA:
undetectable		 4rrzA-4etzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 188
LEU A 192
GLY A 301
ALA A 304
LEU A 307
 None
 1.13A 4rrzB-4etzA:
undetectable		 4rrzB-4etzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 188
LEU A 191
LEU A 203
ALA A 300
LEU A 267
 None
 0.98A 4rs0A-4etzA:
undetectable		 4rs0A-4etzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 332
LEU A 328
LEU A 438
GLU A 428
LEU A 344
 None
 1.17A 4wg0J-4etzA:
undetectable
4wg0K-4etzA:
undetectable
4wg0L-4etzA:
undetectable		 4wg0J-4etzA:
5.52
4wg0K-4etzA:
5.52
4wg0L-4etzA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4etz PELD
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 194
VAL A 188
LEU A 191
ALA A 300
LEU A 267
 None
 1.06A 5kirA-4etzA:
undetectable		 5kirA-4etzA:
19.39