SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  72
GLN A  56
ILE A 207
LEU A 223
THR A 142
 None
 1.18A 1dhfA-4eu2A:
undetectable		 1dhfA-4eu2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  72
GLN A  56
ILE A 207
LEU A 223
THR A 142
 None
 1.20A 1dhfB-4eu2A:
undetectable		 1dhfB-4eu2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 SER A  70
PHE A 233
GLU A 224
GLY A 226
 None
 1.16A 1icuC-4eu2A:
undetectable
1icuD-4eu2A:
undetectable		 1icuC-4eu2A:
25.75
1icuD-4eu2A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  84
LEU A 214
MET A 210
LEU A  43
THR A 142
 None
 1.46A 1p93C-4eu2A:
undetectable		 1p93C-4eu2A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 186
ILE A 194
GLY A  47
THR A  51
ILE A 154
 None
 1.11A 1z11C-4eu2A:
undetectable		 1z11C-4eu2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 186
ILE A 194
GLY A  47
THR A  51
ILE A 154
 None
 1.08A 1z11D-4eu2A:
undetectable		 1z11D-4eu2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  71
SER A  70
GLN A  56
SER A  55
 None
 1.26A 2xz5A-4eu2A:
undetectable
2xz5B-4eu2A:
undetectable		 2xz5A-4eu2A:
20.41
2xz5B-4eu2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 163
GLY A 161
ASP A 158
ILE A 140
VAL A 139
 None
 1.23A 3ay0B-4eu2A:
undetectable		 3ay0B-4eu2A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 186
ILE A 194
GLY A  47
THR A  51
 None
 0.84A 4ejjC-4eu2A:
undetectable		 4ejjC-4eu2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 168
SER A  55
PHE A 218
VAL A  52
THR A 169
 None
 1.47A 4kyaC-4eu2A:
undetectable		 4kyaC-4eu2A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 168
VAL A  45
PHE A 186
SER A 189
ILE A 191
 None
 1.17A 4pd9A-4eu2A:
undetectable		 4pd9A-4eu2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 MET A 121
GLU A 103
ARG A  96
 None
 0.96A 5tjyA-4eu2A:
undetectable		 5tjyA-4eu2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 4eu2 PROTEASOME COMPONENT
C7-ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 MET A 121
GLU A 103
ARG A  96
 None
 0.94A 5tjzA-4eu2A:
undetectable		 5tjzA-4eu2A:
21.34