SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4euo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		3 / 3 ALA A  67
VAL A  74
TRP A  76
 None
 0.95A 1grmA-4euoA:
undetectable		 1grmA-4euoA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		3 / 3 ALA A  67
VAL A  74
TRP A  76
 None
 0.95A 1grmB-4euoA:
undetectable		 1grmB-4euoA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		3 / 3 ILE A 165
ASP A 172
PHE A 145
 None
 0.63A 1uwjB-4euoA:
undetectable		 1uwjB-4euoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		5 / 12 GLY A  83
TYR A 116
SER A 117
ALA A 246
TYR A 123
 None
None
None
None
ABU  A 404 ( 4.0A)
 1.41A 2avdA-4euoA:
undetectable		 2avdA-4euoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 7 ASN A 223
GLY A 224
THR A 282
SER A 302
 None
 0.86A 2o5yH-4euoA:
undetectable
2o5yL-4euoA:
undetectable		 2o5yH-4euoA:
21.02
2o5yL-4euoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		5 / 12 PHE A 218
ALA A 136
VAL A 134
GLY A 152
VAL A 164
 None
 0.90A 3c6gB-4euoA:
undetectable		 3c6gB-4euoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		5 / 12 TRP A  42
PHE A  27
VAL A  48
VAL A  78
LEU A 250
 None
 1.19A 3elzA-4euoA:
undetectable		 3elzA-4euoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 8 ASP A 305
SER A 291
LEU A 108
ASP A 109
 None
 1.03A 3m0wE-4euoA:
undetectable
3m0wF-4euoA:
undetectable
3m0wG-4euoA:
undetectable
3m0wH-4euoA:
undetectable		 3m0wE-4euoA:
14.52
3m0wF-4euoA:
14.52
3m0wG-4euoA:
14.52
3m0wH-4euoA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 7 PHE A 156
GLY A 163
LEU A 191
PHE A 145
 None
 0.89A 4ejjD-4euoA:
undetectable		 4ejjD-4euoA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 7 TYR A 318
HIS A 322
ILE A 326
PRO A 181
 None
 0.78A 4g5jA-4euoA:
undetectable		 4g5jA-4euoA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 4 THR A 114
GLY A  83
ASP A  84
SER A 117
 None
 1.30A 4rfqA-4euoA:
undetectable		 4rfqA-4euoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 7 ASN A 313
TYR A 123
TYR A 284
LEU A 303
 None
ABU  A 404 ( 4.0A)
ABU  A 404 (-4.5A)
None
 1.24A 4yv5A-4euoA:
undetectable		 4yv5A-4euoA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 7 SER A 213
ALA A 212
PRO A 217
LEU A 210
 None
 1.10A 5dzkD-4euoA:
undetectable
5dzkR-4euoA:
undetectable		 5dzkD-4euoA:
25.31
5dzkR-4euoA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 8 SER A 213
ALA A 212
PRO A 217
LEU A 210
 None
 1.08A 5dzkd-4euoA:
undetectable
5dzkr-4euoA:
undetectable		 5dzkd-4euoA:
25.31
5dzkr-4euoA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		5 / 12 GLY A 203
TRP A 159
TYR A 123
PHE A 121
GLN A 208
 None
GOL  A 401 (-3.7A)
ABU  A 404 ( 4.0A)
ABU  A 404 (-4.8A)
None
 1.26A 5t0kA-4euoA:
undetectable		 5t0kA-4euoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		5 / 12 GLY A 203
TRP A 159
TYR A 123
PHE A 121
GLN A 208
 None
GOL  A 401 (-3.7A)
ABU  A 404 ( 4.0A)
ABU  A 404 (-4.8A)
None
 1.25A 5t0kB-4euoA:
undetectable		 5t0kB-4euoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		5 / 12 GLY A 203
TRP A 159
TYR A 123
PHE A 121
GLN A 208
 None
GOL  A 401 (-3.7A)
ABU  A 404 ( 4.0A)
ABU  A 404 (-4.8A)
None
 1.21A 5t0mB-4euoA:
undetectable		 5t0mB-4euoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 6 ILE A 127
ILE A 165
LEU A 191
PHE A 145
 None
 1.06A 5vkqA-4euoA:
undetectable
5vkqB-4euoA:
undetectable		 5vkqA-4euoA:
10.91
5vkqB-4euoA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		4 / 6 ILE A 127
ILE A 165
LEU A 191
PHE A 145
 None
 1.04A 5vkqA-4euoA:
undetectable
5vkqD-4euoA:
undetectable		 5vkqA-4euoA:
10.91
5vkqD-4euoA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		5 / 12 GLY A 203
TRP A 159
TYR A 123
PHE A 121
GLN A 208
 None
GOL  A 401 (-3.7A)
ABU  A 404 ( 4.0A)
ABU  A 404 (-4.8A)
None
 1.22A 5vseA-4euoA:
undetectable		 5vseA-4euoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4euo ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (POLYAMINE)
(Agrobacterium
fabrum) 		5 / 12 GLY A 203
TRP A 159
TYR A 123
PHE A 121
GLN A 208
 None
GOL  A 401 (-3.7A)
ABU  A 404 ( 4.0A)
ABU  A 404 (-4.8A)
None
 1.22A 5vseB-4euoA:
undetectable		 5vseB-4euoA:
20.23