SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ev0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		5 / 12 VAL A 183
LEU A 187
GLY A 174
ALA A 173
LEU A 169
 None
 1.07A 1cqeB-4ev0A:
undetectable		 1cqeB-4ev0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		4 / 8 VAL A 193
LEU A 195
SER A 181
VAL A 180
 None
 1.06A 1jtvA-4ev0A:
undetectable		 1jtvA-4ev0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		5 / 12 VAL A 183
LEU A 184
LEU A 208
LEU A 187
LEU A 151
 None
 1.21A 1mx1C-4ev0A:
undetectable		 1mx1C-4ev0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		5 / 12 PHE A   7
GLY A   9
LEU A  17
VAL A  15
ALA A  18
 None
 0.94A 1v2xA-4ev0A:
undetectable		 1v2xA-4ev0A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		4 / 6 ALA A 130
ASP A 131
GLU A 133
ARG A  63
 None
 1.05A 2ouzA-4ev0A:
undetectable		 2ouzA-4ev0A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		4 / 6 ALA A 130
ASP A 131
GLU A 133
MET A  77
 None
None
None
CMP  A 301 (-4.8A)
 0.85A 2ouzA-4ev0A:
undetectable		 2ouzA-4ev0A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		5 / 12 VAL A 183
LEU A 187
GLY A 174
ALA A 173
LEU A 169
 None
 1.03A 5ikrB-4ev0A:
undetectable		 5ikrB-4ev0A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		5 / 12 LEU A  73
LEU A  45
SER A  20
LEU A  19
LEU A 108
 None
 1.17A 5mwyA-4ev0A:
undetectable		 5mwyA-4ev0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		3 / 3 TYR A  27
ALA A  99
TYR A  44
 None
 0.88A 5uunB-4ev0A:
undetectable		 5uunB-4ev0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		4 / 6 GLY A  49
THR A  95
ILE A  33
PHE A  34
 None
None
None
CMP  A 301 (-4.4A)
 0.88A 6f8cA-4ev0A:
undetectable		 6f8cA-4ev0A:
17.48