SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ev1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		4 / 7 PHE A 136
THR A  75
LEU A 132
VAL A 113
 NHE  A 303 (-4.4A)
None
None
None
 0.99A 1t87A-4ev1A:
undetectable		 1t87A-4ev1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		4 / 7 LEU A  48
ILE A 118
GLN A 124
ARG A 131
 None
 0.74A 2xkwA-4ev1A:
undetectable		 2xkwA-4ev1A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		4 / 6 PHE A 136
THR A  75
LEU A 132
VAL A 113
 NHE  A 303 (-4.4A)
None
None
None
 1.11A 2zuhA-4ev1A:
undetectable		 2zuhA-4ev1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		4 / 6 PHE A 136
THR A  75
LEU A 132
VAL A 113
 NHE  A 303 (-4.4A)
None
None
None
 0.99A 2zuiA-4ev1A:
undetectable		 2zuiA-4ev1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		5 / 9 PHE A 136
LEU A 122
THR A 125
LEU A 115
ILE A 118
 NHE  A 303 (-4.4A)
None
None
None
None
 1.18A 3tbgD-4ev1A:
undetectable		 3tbgD-4ev1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		3 / 3 GLN A 174
ASP A 213
GLN A 215
 None
None
NHE  A 302 (-3.1A)
 0.93A 4aztA-4ev1A:
undetectable		 4aztA-4ev1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		4 / 8 PHE A 136
LEU A 122
VAL A 113
ILE A  46
 NHE  A 303 (-4.4A)
None
None
None
 1.00A 4l4cB-4ev1A:
undetectable		 4l4cB-4ev1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		4 / 5 LEU A 217
ASP A 218
LEU A 191
THR A 225
 NHE  A 302 (-3.8A)
None
NHE  A 302 (-4.5A)
NHE  A 302 (-3.1A)
 1.24A 4wozF-4ev1A:
undetectable
4wozH-4ev1A:
undetectable		 4wozF-4ev1A:
23.32
4wozH-4ev1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		4 / 8 GLY A 221
GLN A 227
LEU A 223
THR A 225
 NHE  A 302 (-3.2A)
None
None
NHE  A 302 (-3.1A)
 0.96A 5syjB-4ev1A:
undetectable		 5syjB-4ev1A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4ev1 ANABENA TIC22
(Anabaena
sp.) 		5 / 10 ALA A  77
TYR A  47
GLU A 247
SER A 242
VAL A 163
 None
None
None
EDO  A 306 ( 2.4A)
None
 1.45A 6b89A-4ev1A:
undetectable		 6b89A-4ev1A:
17.21