SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ev4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
1.03A 1c6zA-4ev4A:
undetectable
1c6zA-4ev4A:
16.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.37A 1ghmA-4ev4A:
37.5
1ghmA-4ev4A:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ALA A  48
ILE A 250
ILE A 285
ILE A 292
ILE A 259
None
0.93A 1hshC-4ev4A:
undetectable
1hshC-4ev4A:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
THR A 216
LYS A 234
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.40A 1i2wA-4ev4A:
40.5
1i2wA-4ev4A:
45.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
GLY A 236
ARG A 220
MER  A 401 (-1.3A)
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-3.6A)
MER  A 401 ( 3.9A)
1.19A 1i2wB-4ev4A:
40.8
1i2wB-4ev4A:
45.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
THR A 216
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.6A)
0.43A 1i2wB-4ev4A:
40.8
1i2wB-4ev4A:
45.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
0.95A 1sdtB-4ev4A:
undetectable
1sdtB-4ev4A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
1.03A 1sduB-4ev4A:
undetectable
1sduB-4ev4A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 10 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
1.02A 1t7iA-4ev4A:
undetectable
1t7iA-4ev4A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
4 / 6 ARG A 284
SER A 224
ILE A 221
THR A 265
None
0.96A 1w0gA-4ev4A:
undetectable
1w0gA-4ev4A:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
8 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.56A 1ymxA-4ev4A:
42.4
1ymxA-4ev4A:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.54A 1ymxB-4ev4A:
42.4
1ymxB-4ev4A:
48.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
0.99A 2hs1A-4ev4A:
undetectable
2hs1A-4ev4A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
0.92A 2hs1B-4ev4A:
undetectable
2hs1B-4ev4A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
0.97A 2q64A-4ev4A:
undetectable
2q64A-4ev4A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 9 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.03A 2vcvD-4ev4A:
undetectable
2vcvD-4ev4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 9 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.00A 2vcvE-4ev4A:
undetectable
2vcvE-4ev4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 9 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
0.98A 2vcvH-4ev4A:
undetectable
2vcvH-4ev4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 9 PRO A 145
LEU A 162
LEU A 139
ALA A 135
PHE A  72
None
1.05A 2vcvI-4ev4A:
undetectable
2vcvI-4ev4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 SER A 289
ASN A 291
THR A  29
VAL A  28
GLN A  24
EDO  A 402 (-2.5A)
None
EDO  A 402 ( 4.7A)
None
None
1.47A 2xpvA-4ev4A:
undetectable
2xpvA-4ev4A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ALA A 185
ASP A 157
MET A 152
PHE A 160
TYR A 264
EDO  A 403 (-3.6A)
EDO  A 403 ( 4.2A)
None
None
None
1.17A 3clbB-4ev4A:
undetectable
3clbB-4ev4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
0.89A 3d1zA-4ev4A:
undetectable
3d1zA-4ev4A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
0.91A 3ekwB-4ev4A:
undetectable
3ekwB-4ev4A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 10 ILE A 279
ILE A 221
GLY A 232
PHE A 211
VAL A 186
None
1.05A 3elzB-4ev4A:
1.1
3elzB-4ev4A:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 12 LYS A  73
SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.58A 3hlwA-4ev4A:
42.3
3hlwA-4ev4A:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 12 SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.50A 3hlwB-4ev4A:
42.4
3hlwB-4ev4A:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A 130
ASN A 132
THR A 216
LYS A 234
THR A 235
GLY A 239
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
None
0.82A 3hlwB-4ev4A:
42.4
3hlwB-4ev4A:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 LYS A  73
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
MER  A 401 ( 4.4A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.47A 3huoA-4ev4A:
42.3
3huoA-4ev4A:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 LYS A  73
ASN A 132
ASN A 170
LYS A 234
GLY A 236
MER  A 401 ( 4.4A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.46A 3huoB-4ev4A:
42.2
3huoB-4ev4A:
48.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A  70
LYS A  73
ASN A 132
THR A 235
GLY A 236
ARG A 220
MER  A 401 (-1.3A)
MER  A 401 ( 4.4A)
MER  A 401 (-3.2A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 ( 3.9A)
0.77A 3mzeA-4ev4A:
21.8
3mzeA-4ev4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
0.93A 3nu3A-4ev4A:
undetectable
3nu3A-4ev4A:
17.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
9 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
ARG A 220
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.58A 3ny4A-4ev4A:
39.0
3ny4A-4ev4A:
43.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.44A 3q07A-4ev4A:
42.2
3q07A-4ev4A:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.56A 3q07B-4ev4A:
39.4
3q07B-4ev4A:
48.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A  70
SER A 130
ASN A 132
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.48A 3sh8A-4ev4A:
39.6
3sh8A-4ev4A:
43.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 ( 4.4A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.48A 3sh8B-4ev4A:
39.3
3sh8B-4ev4A:
43.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
4 / 7 ASP A 131
GLY A 133
ALA A 134
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
0.59A 3t3cA-4ev4A:
undetectable
3t3cA-4ev4A:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
11 / 12 LYS A  73
HIS A 105
SER A 130
ASN A 132
LEU A 167
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 ( 4.4A)
MER  A 401 ( 3.7A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
None
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.57A 4euzA-4ev4A:
50.8
4euzA-4ev4A:
99.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 10 SER A 130
ASN A 132
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.56A 4fh2A-4ev4A:
35.2
4fh2A-4ev4A:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
4 / 8 GLN A 112
GLY A 116
THR A 115
THR A 118
EDO  A 404 ( 4.3A)
None
EDO  A 404 (-4.0A)
None
0.83A 4k87A-4ev4A:
undetectable
4k87A-4ev4A:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 12 SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.40A 4n9kA-4ev4A:
41.1
4n9kA-4ev4A:
43.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 12 SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.43A 4n9kB-4ev4A:
40.9
4n9kB-4ev4A:
43.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
1.11A 4njvD-4ev4A:
undetectable
4njvD-4ev4A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
4 / 6 LEU A  90
LEU A 138
PHE A 211
MET A 208
None
0.84A 4o1zA-4ev4A:
undetectable
4o1zA-4ev4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 GLY A  74
LEU A 207
VAL A 249
ILE A 155
VAL A 198
None
1.06A 4ok1A-4ev4A:
undetectable
4ok1A-4ev4A:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 ASN A 132
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.46A 4pm5A-4ev4A:
42.1
4pm5A-4ev4A:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM5_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.75A 4pm5A-4ev4A:
42.1
4pm5A-4ev4A:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 LYS A  73
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
MER  A 401 ( 4.4A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.58A 4pm7A-4ev4A:
42.0
4pm7A-4ev4A:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 ASN A 132
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.47A 4pm9A-4ev4A:
41.9
4pm9A-4ev4A:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.75A 4pm9A-4ev4A:
41.9
4pm9A-4ev4A:
48.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 9 LEU A  33
GLY A  45
SER A 283
VAL A 286
LEU A 287
None
1.00A 4qd3A-4ev4A:
undetectable
4qd3A-4ev4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 SER A 289
ASN A 291
THR A  29
VAL A  28
GLN A  24
EDO  A 402 (-2.5A)
None
EDO  A 402 ( 4.7A)
None
None
1.43A 4v2gB-4ev4A:
undetectable
4v2gB-4ev4A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
4 / 7 ASP A 246
ILE A 221
GLY A 232
THR A 235
None
None
None
MER  A 401 (-3.5A)
1.16A 4zxiA-4ev4A:
undetectable
4zxiA-4ev4A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
3 / 3 ASP A  98
ARG A  96
TYR A  97
None
0.99A 5a7mA-4ev4A:
undetectable
5a7mA-4ev4A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
3 / 3 ASP A  98
ARG A  96
TYR A  97
None
1.01A 5a7mB-4ev4A:
undetectable
5a7mB-4ev4A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 PHE A 195
VAL A 249
ILE A 250
PHE A 290
ILE A 292
None
None
None
EDO  A 402 ( 3.7A)
None
1.21A 5b8iC-4ev4A:
undetectable
5b8iC-4ev4A:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.50A 5ghyA-4ev4A:
40.9
5ghyA-4ev4A:
43.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.48A 5ghyB-4ev4A:
40.9
5ghyB-4ev4A:
43.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 11 SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.47A 5ghzA-4ev4A:
40.9
5ghzA-4ev4A:
43.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 10 SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
THR A 235
GLY A 236
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
0.47A 5ghzB-4ev4A:
41.0
5ghzB-4ev4A:
43.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
4 / 6 PHE A  66
THR A 265
TYR A 264
PHE A  75
None
1.27A 5lrbA-4ev4A:
undetectable
5lrbA-4ev4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
4 / 7 THR A 149
PHE A  72
ASP A 179
LEU A 169
None
1.14A 5uxcA-4ev4A:
undetectable
5uxcA-4ev4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
4 / 6 LEU A 169
LYS A  73
LEU A  76
LEU A 139
None
MER  A 401 ( 4.4A)
None
None
1.08A 5yvnA-4ev4A:
undetectable
5yvnA-4ev4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
9 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
ARG A 220
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.41A 6b5yB-4ev4A:
39.5
6b5yB-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A 130
THR A 216
ARG A 220
THR A 235
THR A 237
GLY A 239
MER  A 401 (-2.8A)
MER  A 401 ( 3.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.5A)
MER  A 401 (-3.7A)
None
0.81A 6b5yB-4ev4A:
39.5
6b5yB-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
8 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.48A 6b5yD-4ev4A:
39.6
6b5yD-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
8 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.34A 6b68B-4ev4A:
39.6
6b68B-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
8 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
ARG A 220
LYS A 234
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.42A 6b68D-4ev4A:
39.5
6b68D-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
8 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.32A 6b69A-4ev4A:
39.4
6b69B-4ev4A:
39.6
6b69A-4ev4A:
18.10
6b69B-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 12 SER A  70
SER A 130
PRO A 104
THR A 216
LYS A 234
THR A 235
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
None
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.7A)
1.34A 6b69A-4ev4A:
39.4
6b69B-4ev4A:
39.6
6b69A-4ev4A:
18.10
6b69B-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
9 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
ARG A 220
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.33A 6b69D-4ev4A:
39.5
6b69D-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
9 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
ARG A 220
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.37A 6b6aB-4ev4A:
39.4
6b6aB-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
8 / 12 SER A  70
SER A 130
ASN A 170
ARG A 220
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.39A 6b6aD-4ev4A:
39.3
6b6aD-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
8 / 12 SER A  70
SER A 130
ASN A 170
ARG A 220
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.48A 6b6cA-4ev4A:
39.2
6b6cA-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
7 / 12 SER A  70
SER A 130
PRO A 104
ARG A 220
LYS A 234
THR A 235
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
None
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.7A)
1.29A 6b6cA-4ev4A:
39.2
6b6cA-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
8 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.58A 6b6dA-4ev4A:
39.4
6b6dA-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
9 / 12 SER A  70
SER A 130
ASN A 170
THR A 216
ARG A 220
LYS A 234
THR A 235
GLY A 236
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.39A 6b6eA-4ev4A:
39.4
6b6eA-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
8 / 12 CSS A  69
SER A  70
SER A 130
ASN A 170
LYS A 234
THR A 235
GLY A 236
THR A 237
None
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
MER  A 401 (-2.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.6A)
MER  A 401 (-3.7A)
0.48A 6b6fA-4ev4A:
39.0
6b6fA-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A  70
SER A 130
PRO A 104
LYS A 234
THR A 235
THR A 237
MER  A 401 (-1.3A)
MER  A 401 (-2.8A)
None
MER  A 401 (-3.0A)
MER  A 401 (-3.5A)
MER  A 401 (-3.7A)
1.43A 6b6fA-4ev4A:
39.0
6b6fA-4ev4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
6 / 12 SER A 130
ASN A 132
ASN A 170
THR A 216
LYS A 234
GLY A 236
MER  A 401 (-2.8A)
MER  A 401 (-3.2A)
MER  A 401 (-2.9A)
MER  A 401 ( 3.9A)
MER  A 401 (-3.0A)
MER  A 401 (-3.6A)
0.45A 6c79A-4ev4A:
42.3
6c79A-4ev4A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
5 / 12 ASP A 131
GLY A 133
ALA A 134
ILE A  95
ILE A 113
None
HAR  A 100 ( 3.6A)
None
None
None
0.96A 6dh3B-4ev4A:
undetectable
6dh3B-4ev4A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)
4ev4 CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1

(Serratia
fonticola)
4 / 5 ARG A 153
GLY A 156
ASN A 158
ASP A 157
None
None
EDO  A 403 (-4.7A)
EDO  A 403 ( 4.2A)
1.37A 6dwjB-4ev4A:
undetectable
6dwjD-4ev4A:
undetectable
6dwjB-4ev4A:
20.19
6dwjD-4ev4A:
20.19