SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4evi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		4 / 4 LYS A 283
LEU A 279
ALA A 347
LEU A 343
 None
 1.27A 1f86B-4eviA:
undetectable		 1f86B-4eviA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 10 GLY A 208
ASP A 231
LEU A 232
VAL A 235
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.8A)
None
 0.32A 1fpqA-4eviA:
3.2		 1fpqA-4eviA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 209
GLY A 210
LEU A 232
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
None
 0.54A 1qzzA-4eviA:
25.3		 1qzzA-4eviA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 209
GLY A 210
LEU A 232
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
None
 0.36A 1xdsA-4eviA:
28.1		 1xdsA-4eviA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 209
GLY A 210
LEU A 232
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
None
 0.43A 1xdsB-4eviA:
26.8		 1xdsB-4eviA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 MET A 179
ALA A 180
VAL A 235
ASP A 231
GLY A 178
 SAH  A 401 (-3.6A)
None
SAH  A 401 (-4.8A)
SAH  A 401 (-2.9A)
None
 1.36A 2dcfA-4eviA:
undetectable		 2dcfA-4eviA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 ASP A 247
ASN A 245
ILE A 225
SER A 202
ALA A 219
 None
 1.19A 2ejtA-4eviA:
8.2		 2ejtA-4eviA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 210
GLY A 212
LEU A 232
VAL A 269
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 ( 4.4A)
SAH  A 401 ( 4.5A)
 0.78A 2oxtB-4eviA:
8.6		 2oxtB-4eviA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		6 / 12 ASP A 206
GLY A 208
GLY A 210
GLY A 212
LEU A 232
VAL A 269
 None
SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 ( 4.4A)
SAH  A 401 ( 4.5A)
 1.31A 2oxtD-4eviA:
8.8		 2oxtD-4eviA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 210
LEU A 232
ASN A 252
PHE A 254
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-3.3A)
SAH  A 401 ( 4.8A)
 0.64A 3eluA-4eviA:
7.9		 3eluA-4eviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 210
LEU A 232
ASN A 252
PHE A 254
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-3.3A)
SAH  A 401 ( 4.8A)
 0.60A 3elwA-4eviA:
7.7		 3elwA-4eviA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 MET A 179
GLY A 209
LEU A 232
ASP A 272
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.4A)
C9M  A 402 ( 2.3A)
None
 1.06A 3i5uA-4eviA:
25.3		 3i5uA-4eviA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		7 / 12 PHE A 175
MET A 179
GLY A 209
GLY A 210
LEU A 232
ASP A 272
TRP A 273
 SAH  A 401 (-4.8A)
SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
C9M  A 402 ( 2.3A)
None
 0.52A 3i5uA-4eviA:
25.3		 3i5uA-4eviA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		6 / 12 MET A 179
GLY A 209
GLY A 210
LEU A 232
ASP A 272
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
C9M  A 402 ( 2.3A)
None
 0.47A 3i5uB-4eviA:
25.4		 3i5uB-4eviA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 MET A 179
GLY A 209
LEU A 232
ASP A 272
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.4A)
C9M  A 402 ( 2.3A)
None
 1.07A 3i5uB-4eviA:
25.4		 3i5uB-4eviA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		4 / 8 ILE A  41
GLN A  82
ALA A 101
LEU A 100
 None
 0.82A 3ozwA-4eviA:
2.6		 3ozwA-4eviA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 212
VAL A 205
GLY A 181
SER A 183
ASP A 302
 None
None
None
SAH  A 401 (-2.4A)
None
 0.95A 3sueC-4eviA:
undetectable		 3sueC-4eviA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 210
VAL A 235
ASP A 272
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.8A)
C9M  A 402 ( 2.3A)
None
 0.29A 4a6eA-4eviA:
34.0		 4a6eA-4eviA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 11 ASP A 206
GLY A 208
GLY A 210
ASP A 231
ASN A 252
 None
SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.9A)
SAH  A 401 (-3.3A)
 0.46A 4dcmA-4eviA:
11.0		 4dcmA-4eviA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 210
ASN A 252
MET A 253
TYR A 162
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.1A)
SAH  A 401 ( 3.6A)
 1.10A 4f84A-4eviA:
13.2		 4f84A-4eviA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 210
LEU A 232
ASN A 252
MET A 253
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.1A)
 0.65A 4f84A-4eviA:
13.2		 4f84A-4eviA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 MET A  71
LEU A  74
LEU A  77
LEU A 103
ILE A  37
 None
 1.16A 4j24A-4eviA:
undetectable		 4j24A-4eviA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		4 / 6 PHE A 198
MET A 299
ILE A 218
VAL A 357
 None
 1.25A 4mk4B-4eviA:
2.0		 4mk4B-4eviA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		3 / 3 THR A 211
ASN A 170
PHE A 171
 None
 0.71A 4pd9A-4eviA:
undetectable		 4pd9A-4eviA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		8 / 11 GLY A 208
GLY A 209
THR A 214
ASP A 231
LEU A 232
VAL A 235
MET A 253
LYS A 267
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
None
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
 0.59A 4pghA-4eviA:
33.4		 4pghA-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		6 / 11 GLY A 208
GLY A 209
THR A 214
VAL A 236
MET A 253
LYS A 267
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
None
None
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
 1.07A 4pghA-4eviA:
33.4		 4pghA-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		7 / 11 SER A 183
GLY A 208
GLY A 209
ASP A 231
LEU A 232
MET A 253
LYS A 267
 SAH  A 401 (-2.4A)
SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
 0.92A 4pghA-4eviA:
33.4		 4pghA-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		6 / 11 SER A 183
GLY A 208
GLY A 209
VAL A 236
MET A 253
LYS A 267
 SAH  A 401 (-2.4A)
SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
None
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
 1.25A 4pghA-4eviA:
33.4		 4pghA-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		9 / 12 ASP A 206
GLY A 208
THR A 214
ASP A 231
LEU A 232
MET A 253
LYS A 267
ASP A 272
TRP A 273
 None
SAH  A 401 (-3.6A)
None
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 2.3A)
None
 0.67A 4pghB-4eviA:
34.0		 4pghB-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		9 / 12 SER A 183
ASP A 206
GLY A 208
ASP A 231
LEU A 232
MET A 253
LYS A 267
ASP A 272
TRP A 273
 SAH  A 401 (-2.4A)
None
SAH  A 401 (-3.6A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 2.3A)
None
 0.86A 4pghB-4eviA:
34.0		 4pghB-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		8 / 11 GLY A 208
ASP A 231
LEU A 232
VAL A 235
MET A 253
LYS A 267
TRP A 268
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 3.8A)
None
 0.81A 4pghC-4eviA:
33.2		 4pghC-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 11 GLY A 209
ASP A 231
VAL A 235
LYS A 267
TRP A 268
 SAH  A 401 ( 3.9A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.8A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 3.8A)
 1.34A 4pghC-4eviA:
33.2		 4pghC-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		7 / 11 SER A 183
GLY A 208
ASP A 231
LEU A 232
MET A 253
LYS A 267
TRP A 273
 SAH  A 401 (-2.4A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
None
 0.87A 4pghC-4eviA:
33.2		 4pghC-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 11 SER A 183
GLY A 208
VAL A 236
MET A 253
LYS A 267
 SAH  A 401 (-2.4A)
SAH  A 401 (-3.6A)
None
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
 1.26A 4pghC-4eviA:
33.2		 4pghC-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		9 / 12 GLY A 208
GLY A 209
THR A 214
ASP A 231
LEU A 232
MET A 253
PHE A 254
LYS A 267
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
None
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 ( 4.8A)
SAH  A 401 (-2.4A)
None
 0.89A 4pghD-4eviA:
33.4		 4pghD-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		8 / 12 GLY A 210
THR A 214
ASP A 231
LEU A 232
MET A 253
PHE A 254
LYS A 267
TRP A 273
 SAH  A 401 ( 3.8A)
None
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 ( 4.8A)
SAH  A 401 (-2.4A)
None
 1.33A 4pghD-4eviA:
33.4		 4pghD-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		9 / 12 SER A 183
GLY A 208
GLY A 209
ASP A 231
LEU A 232
MET A 253
PHE A 254
LYS A 267
TRP A 273
 SAH  A 401 (-2.4A)
SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 ( 4.8A)
SAH  A 401 (-2.4A)
None
 1.04A 4pghD-4eviA:
33.4		 4pghD-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		8 / 12 SER A 183
GLY A 210
ASP A 231
LEU A 232
MET A 253
PHE A 254
LYS A 267
TRP A 273
 SAH  A 401 (-2.4A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 ( 4.8A)
SAH  A 401 (-2.4A)
None
 1.39A 4pghD-4eviA:
33.4		 4pghD-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 THR A 336
VAL A 304
GLN A 339
ILE A 300
TYR A 352
 None
 1.42A 4s0vA-4eviA:
undetectable		 4s0vA-4eviA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 11 ALA A 347
LEU A 282
LEU A 270
VAL A 366
TRP A 340
 None
 1.28A 5eb5A-4eviA:
undetectable		 5eb5A-4eviA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		3 / 3 GLY A 210
ASP A 231
ASN A 252
 SAH  A 401 ( 3.8A)
SAH  A 401 (-2.9A)
SAH  A 401 (-3.3A)
 0.37A 5jglA-4eviA:
13.1		 5jglA-4eviA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 209
LEU A 232
VAL A 235
ASP A 272
TRP A 273
 SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.8A)
C9M  A 402 ( 2.3A)
None
 0.39A 5w7pA-4eviA:
26.5		 5w7pA-4eviA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 10 LEU A  35
ALA A  32
LEU A  74
MET A  73
ILE A  24
 None
 1.27A 6cbzB-4eviA:
undetectable		 6cbzB-4eviA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		4 / 6 ASP A 272
LEU A 127
SER A 122
PHE A 171
 C9M  A 402 ( 2.3A)
None
C9M  A 402 (-2.6A)
None
 1.09A 6ekuA-4eviA:
undetectable		 6ekuA-4eviA:
19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 11 GLY A 208
GLY A 210
ASP A 231
ASP A 256
LYS A 267
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.9A)
None
SAH  A 401 (-2.4A)
 1.20A 6i5zD-4eviA:
30.8		 6i5zD-4eviA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		9 / 11 GLY A 208
GLY A 210
ASP A 231
LEU A 232
VAL A 235
MET A 253
LYS A 267
TRP A 268
ASP A 272
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 3.8A)
C9M  A 402 ( 2.3A)
 0.75A 6i5zD-4eviA:
30.8		 6i5zD-4eviA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		6 / 11 GLY A 209
ASP A 231
LEU A 232
MET A 253
TRP A 268
ASP A 272
 SAH  A 401 ( 3.9A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
C9M  A 402 ( 3.8A)
C9M  A 402 ( 2.3A)
 1.28A 6i5zD-4eviA:
30.8		 6i5zD-4eviA:
31.23