SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4evw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 PRO A 124
VAL A 122
TYR A 133
GLU A 135
 None
 1.37A 1m8dA-4evwA:
undetectable		 1m8dA-4evwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 PRO A 124
VAL A 122
TYR A 133
GLU A 135
 None
 1.38A 1m8dB-4evwA:
undetectable		 1m8dB-4evwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 PRO A 124
VAL A 122
TYR A 133
GLU A 135
 None
 1.48A 1m9jA-4evwA:
undetectable		 1m9jA-4evwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 PRO A 124
VAL A 122
TYR A 133
GLU A 135
 None
 1.37A 1m9jB-4evwA:
undetectable		 1m9jB-4evwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLY A 139
GLN A 138
VAL A 136
SER A 167
 None
 1.18A 1p6kB-4evwA:
undetectable		 1p6kB-4evwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLY A 139
GLN A 138
VAL A 136
SER A 167
 None
 1.20A 1rs6B-4evwA:
undetectable		 1rs6B-4evwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLY A 139
GLN A 138
VAL A 136
SER A 167
 None
 1.20A 1zzuB-4evwA:
undetectable		 1zzuB-4evwA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		3 / 3 LYS A   1
TYR A 105
PRO A  48
 None
 1.48A 2j9cC-4evwA:
undetectable		 2j9cC-4evwA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		5 / 12 LEU A 134
ILE A 126
SER A 127
PHE A 123
THR A 110
 None
 1.27A 3bjwF-4evwA:
undetectable		 3bjwF-4evwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 7 TYR A 190
GLU A 197
TRP A 198
LEU A 203
 None
MG  A 301 ( 4.1A)
None
None
 1.39A 3k8mB-4evwA:
undetectable		 3k8mB-4evwA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 7 PRO A   5
ILE A 205
LEU A 208
THR A  90
 None
 0.94A 3p50A-4evwA:
undetectable		 3p50A-4evwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 7 PRO A   5
ILE A 205
LEU A 208
THR A  90
 None
 0.93A 3p50B-4evwA:
undetectable		 3p50B-4evwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 7 PRO A   5
ILE A 205
LEU A 208
THR A  90
 None
 0.93A 3p50C-4evwA:
undetectable		 3p50C-4evwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 7 PRO A   5
ILE A 205
LEU A 208
THR A  90
 None
 0.94A 3p50D-4evwA:
undetectable		 3p50D-4evwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 7 PRO A   5
ILE A 205
LEU A 208
THR A  90
 None
 0.89A 3p50E-4evwA:
undetectable		 3p50E-4evwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		5 / 10 LEU A  80
GLY A  94
VAL A 111
ILE A   4
VAL A   3
 None
 1.08A 4jx1B-4evwA:
undetectable		 4jx1B-4evwA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 4 TYR A 183
THR A  90
VAL A   3
ILE A 205
 None
 0.99A 4jx1F-4evwA:
undetectable		 4jx1F-4evwA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLU A 202
GLU A  89
THR A  92
LEU A 208
 None
 1.14A 5hm8A-4evwA:
undetectable		 5hm8A-4evwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLU A 202
GLU A  89
THR A  92
LEU A 208
 None
 1.14A 5hm8B-4evwA:
undetectable		 5hm8B-4evwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLU A 202
GLU A  89
THR A  92
LEU A 208
 None
 1.14A 5hm8C-4evwA:
undetectable		 5hm8C-4evwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLU A 202
GLU A  89
THR A  92
LEU A 208
 None
 1.14A 5hm8D-4evwA:
undetectable		 5hm8D-4evwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLU A 202
GLU A  89
THR A  92
LEU A 208
 None
 1.14A 5hm8E-4evwA:
undetectable		 5hm8E-4evwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLU A 202
GLU A  89
THR A  92
LEU A 208
 None
 1.13A 5hm8F-4evwA:
undetectable		 5hm8F-4evwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLU A 202
GLU A  89
THR A  92
LEU A 208
 None
 1.23A 5hm8G-4evwA:
undetectable		 5hm8G-4evwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		4 / 5 GLU A 202
GLU A  89
THR A  92
LEU A 208
 None
 1.14A 5hm8H-4evwA:
undetectable		 5hm8H-4evwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE
(Vibrio
cholerae) 		5 / 12 PHE A  62
ILE A 114
PHE A  51
ALA A  41
GLY A  71
 None
 0.99A 5veuA-4evwA:
undetectable		 5veuA-4evwA:
21.99