SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4evz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 12 GLY A 203
ASP A 183
ALA A 225
SER A 226
LEU A  50
 PI  A 301 (-3.7A)
None
PI  A 301 (-3.5A)
PI  A 301 (-2.5A)
None
 1.33A 1kiaD-4evzA:
undetectable		 1kiaD-4evzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 12 PHE A 228
ALA A 224
ALA A 222
LEU A 216
ARG A 245
 None
PI  A 301 (-3.8A)
None
None
None
 1.28A 1kt5A-4evzA:
undetectable		 1kt5A-4evzA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 11 ILE A 113
ALA A 165
GLY A 166
GLU A 167
LYS A  99
 None
 1.37A 1n6cA-4evzA:
undetectable		 1n6cA-4evzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 7 SER A 201
HIS A 229
GLY A 177
ASP A 176
 PI  A 301 ( 4.7A)
None
PI  A 301 (-3.5A)
PI  A 301 (-3.6A)
 1.04A 2ddwB-4evzA:
undetectable		 2ddwB-4evzA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 8 ALA A 131
THR A 149
ASN A 103
ILE A 129
 None
None
PI  A 302 (-3.9A)
None
 0.78A 2dtjA-4evzA:
undetectable
2dtjB-4evzA:
undetectable		 2dtjA-4evzA:
24.09
2dtjB-4evzA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 8 GLU A 167
ILE A 199
GLU A  46
ILE A   7
 None
 0.94A 2j9dJ-4evzA:
undetectable
2j9dK-4evzA:
undetectable
2j9dL-4evzA:
undetectable		 2j9dJ-4evzA:
21.46
2j9dK-4evzA:
21.46
2j9dL-4evzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 9 VAL A 107
THR A 149
ASP A 130
ILE A 129
VAL A 140
 None
 1.44A 2l8mA-4evzA:
undetectable		 2l8mA-4evzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 12 ALA A 221
ALA A 222
PHE A 214
ILE A 235
LEU A  10
 None
 1.02A 2nyrA-4evzA:
undetectable		 2nyrA-4evzA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 10 PHE A 228
ALA A 224
ALA A 222
LEU A 242
VAL A 249
 None
PI  A 301 (-3.8A)
None
None
None
 1.33A 2wuzA-4evzA:
undetectable		 2wuzA-4evzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 10 PHE A 228
ALA A 224
ALA A 222
LEU A 242
VAL A 249
 None
PI  A 301 (-3.8A)
None
None
None
 1.29A 2wuzB-4evzA:
undetectable		 2wuzB-4evzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 8 PHE A 228
ALA A 224
ALA A 222
LEU A 242
 None
PI  A 301 (-3.8A)
None
None
 1.03A 2wx2B-4evzA:
undetectable		 2wx2B-4evzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4evz HISF-LUCA
(synthetic
construct) 		3 / 3 GLY A 202
TYR A 182
SER A 201
 PI  A 301 (-3.5A)
None
PI  A 301 ( 4.7A)
 0.69A 2xatA-4evzA:
undetectable		 2xatA-4evzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 7 PHE A 230
GLY A  20
ASP A  28
ARG A  16
 None
 0.97A 3aruA-4evzA:
9.9		 3aruA-4evzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 5 VAL A 154
PHE A 141
ARG A 158
ARG A 188
 None
 1.47A 3bjwE-4evzA:
undetectable		 3bjwE-4evzA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4evz HISF-LUCA
(synthetic
construct) 		3 / 3 MET A  62
VAL A  33
GLU A  67
 None
 0.89A 3c6gA-4evzA:
undetectable		 3c6gA-4evzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 10 TYR A 182
ILE A   6
LYS A 179
GLY A 203
VAL A  48
 None
None
None
PI  A 301 (-3.7A)
None
 1.27A 3em0A-4evzA:
undetectable		 3em0A-4evzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4evz HISF-LUCA
(synthetic
construct) 		3 / 3 PRO A   8
PHE A  49
ALA A  36
 None
 0.66A 3itaD-4evzA:
undetectable		 3itaD-4evzA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 8 GLN A 123
PHE A 120
GLY A 121
GLY A  96
 None
 0.99A 3v3nB-4evzA:
undetectable		 3v3nB-4evzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 8 GLN A 123
PHE A 120
GLY A 121
GLY A  96
 None
 1.00A 3v3nC-4evzA:
undetectable		 3v3nC-4evzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 9 ALA A 222
ALA A 221
ILE A 227
GLY A 203
ALA A 224
 None
None
None
PI  A 301 (-3.7A)
PI  A 301 (-3.8A)
 1.14A 4qvqK-4evzA:
undetectable
4qvqL-4evzA:
undetectable		 4qvqK-4evzA:
22.06
4qvqL-4evzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 9 ALA A 222
ALA A 221
ILE A 227
GLY A 203
ALA A 224
 None
None
None
PI  A 301 (-3.7A)
PI  A 301 (-3.8A)
 1.14A 4qvqY-4evzA:
undetectable
4qvqZ-4evzA:
undetectable		 4qvqY-4evzA:
22.06
4qvqZ-4evzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 12 GLY A 144
ALA A 105
LEU A 112
ALA A  54
GLY A  82
 None
None
None
None
PI  A 302 (-3.6A)
 0.90A 5jglB-4evzA:
undetectable		 5jglB-4evzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 8 TYR A 182
SER A 201
THR A 171
PRO A   8
 None
PI  A 301 ( 4.7A)
None
None
 1.06A 5jhdE-4evzA:
undetectable
5jhdG-4evzA:
undetectable		 5jhdE-4evzA:
22.34
5jhdG-4evzA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4evz HISF-LUCA
(synthetic
construct) 		5 / 12 LEU A 112
ALA A 116
MET A  62
ILE A  83
LEU A  77
 None
 1.33A 5ljbA-4evzA:
undetectable		 5ljbA-4evzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 5 VAL A  65
THR A  61
LEU A  77
LEU A  93
 None
 1.03A 6bqgA-4evzA:
undetectable		 6bqgA-4evzA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4evz HISF-LUCA
(synthetic
construct) 		4 / 6 GLU A  64
ARG A  68
VAL A  12
PRO A  32
 None
 1.44A 6fgdA-4evzA:
undetectable		 6fgdA-4evzA:
23.37