SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ew6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		4 / 6 SER A 229
PHE A 220
ILE A 232
ASP A 231
 None
 1.03A 1yc2A-4ew6A:
5.2		 1yc2A-4ew6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 11 LEU A 214
VAL A 140
LEU A 250
VAL A 177
ILE A 232
 None
 1.00A 2uxoB-4ew6A:
undetectable		 2uxoB-4ew6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		3 / 3 VAL A 166
TRP A 230
TRP A 144
 None
 1.26A 2xdcA-4ew6A:
undetectable
2xdcB-4ew6A:
undetectable		 2xdcA-4ew6A:
5.58
2xdcB-4ew6A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		3 / 3 TRP A 144
VAL A 166
TRP A 230
 None
 1.26A 2xdcA-4ew6A:
undetectable
2xdcB-4ew6A:
undetectable		 2xdcA-4ew6A:
5.58
2xdcB-4ew6A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		3 / 3 VAL A 166
TRP A 230
TRP A 144
 None
 1.13A 2xdcC-4ew6A:
undetectable
2xdcD-4ew6A:
undetectable		 2xdcC-4ew6A:
5.58
2xdcD-4ew6A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		3 / 3 VAL A 166
TRP A 230
TRP A 144
 None
 1.26A 2y5mA-4ew6A:
undetectable
2y5mB-4ew6A:
undetectable		 2y5mA-4ew6A:
5.58
2y5mB-4ew6A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		3 / 3 VAL A 166
TRP A 230
TRP A 144
 None
 1.25A 2y6nA-4ew6A:
undetectable
2y6nB-4ew6A:
undetectable		 2y6nA-4ew6A:
5.58
2y6nB-4ew6A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		3 / 3 TRP A 144
VAL A 166
TRP A 230
 None
 1.27A 2y6nA-4ew6A:
undetectable
2y6nB-4ew6A:
undetectable		 2y6nA-4ew6A:
5.58
2y6nB-4ew6A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		4 / 8 TYR A 269
ILE A  14
TYR A 265
HIS A 118
 None
 0.92A 2zm8A-4ew6A:
undetectable		 2zm8A-4ew6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		4 / 8 TYR A 269
ILE A  14
TYR A 265
HIS A 118
 None
 0.95A 2zmaA-4ew6A:
undetectable		 2zmaA-4ew6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.31A 3fhjA-4ew6A:
undetectable		 3fhjA-4ew6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.32A 3fhjC-4ew6A:
undetectable		 3fhjC-4ew6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 10 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.31A 3fhjE-4ew6A:
undetectable		 3fhjE-4ew6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.34A 3fi0A-4ew6A:
undetectable		 3fi0A-4ew6A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.37A 3fi0C-4ew6A:
undetectable		 3fi0C-4ew6A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.32A 3fi0D-4ew6A:
undetectable		 3fi0D-4ew6A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.34A 3fi0H-4ew6A:
undetectable		 3fi0H-4ew6A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.32A 3fi0K-4ew6A:
undetectable		 3fi0K-4ew6A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.29A 3fi0N-4ew6A:
undetectable		 3fi0N-4ew6A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.27A 3fi0O-4ew6A:
undetectable		 3fi0O-4ew6A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 165
GLN A 160
ASP A 168
ILE A 171
VAL A 291
 None
 1.33A 3fi0R-4ew6A:
undetectable		 3fi0R-4ew6A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 12 GLU A 196
ALA A 305
PHE A 194
ALA A 203
VAL A 303
 None
 1.23A 3nvkF-4ew6A:
undetectable
3nvkJ-4ew6A:
5.6		 3nvkF-4ew6A:
23.72
3nvkJ-4ew6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		3 / 3 VAL A 166
TRP A 230
TRP A 144
 None
 1.13A 3zq8A-4ew6A:
undetectable
3zq8B-4ew6A:
undetectable		 3zq8A-4ew6A:
5.58
3zq8B-4ew6A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A  10
GLY A  12
CYH A  66
GLU A  89
GLN A  18
 None
 1.36A 4l8wG-4ew6A:
3.4		 4l8wG-4ew6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		4 / 7 GLN A 240
THR A 236
THR A 135
THR A 178
 None
 1.12A 4mbsA-4ew6A:
undetectable		 4mbsA-4ew6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		4 / 6 ASP A  61
LYS A  84
HIS A  85
ILE A 276
 None
 0.63A 5a06A-4ew6A:
28.6		 5a06A-4ew6A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		4 / 5 ASP A  61
LYS A  84
HIS A  85
ILE A 276
 None
 0.69A 5a06B-4ew6A:
28.6		 5a06B-4ew6A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		4 / 5 ASP A  61
LYS A  84
HIS A  85
ILE A 276
 None
 0.64A 5a06D-4ew6A:
28.4		 5a06D-4ew6A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		4 / 5 ASP A  61
LYS A  84
HIS A  85
ILE A 276
 None
 0.63A 5a06F-4ew6A:
28.5		 5a06F-4ew6A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A  65
ALA A  75
MET A  53
ALA A   7
ILE A  60
 None
 1.12A 5itzB-4ew6A:
3.7		 5itzB-4ew6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 12 LEU A  65
ALA A  75
MET A  53
ALA A   7
ILE A  60
 None
 1.13A 5nm5B-4ew6A:
4.5		 5nm5B-4ew6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 9 GLY A 165
LEU A 164
ILE A 171
GLY A 170
ILE A  14
 None
 0.90A 5vkqC-4ew6A:
undetectable
5vkqD-4ew6A:
undetectable		 5vkqC-4ew6A:
11.51
5vkqD-4ew6A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN
(Rhizobium
etli) 		5 / 10 TYR A  73
ALA A  75
LEU A  65
LEU A  88
VAL A  86
 None
 1.20A 6g2pB-4ew6A:
undetectable		 6g2pB-4ew6A:
19.86