SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ewf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
LYS A  52
SER A 110
ASN A 112
LYS A 213
GLY A 215
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.35A 1ghmA-4ewfA:
28.9		 1ghmA-4ewfA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
LYS A  52
SER A 110
ASN A 112
LYS A 213
GLY A 215
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.34A 1i2wA-4ewfA:
30.8		 1i2wA-4ewfA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
LYS A  52
SER A 110
ASN A 112
GLY A 215
ARG A 197
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.5A)
SO4  A 301 ( 3.7A)
 0.98A 1i2wB-4ewfA:
30.8		 1i2wB-4ewfA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 11 LEU A 234
THR A 233
THR A 257
ILE A 253
VAL A 238
 None
 1.23A 1pkvA-4ewfA:
undetectable
1pkvB-4ewfA:
undetectable		 1pkvA-4ewfA:
16.54
1pkvB-4ewfA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 11 VAL A 238
LEU A 234
THR A 233
THR A 257
ILE A 253
 None
 1.24A 1pkvA-4ewfA:
undetectable
1pkvB-4ewfA:
undetectable		 1pkvA-4ewfA:
16.54
1pkvB-4ewfA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 7 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.14A 1v55C-4ewfA:
undetectable
1v55N-4ewfA:
undetectable
1v55P-4ewfA:
undetectable		 1v55C-4ewfA:
21.38
1v55N-4ewfA:
20.12
1v55P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
LYS A  52
SER A 110
ASN A 112
LYS A 213
GLY A 215
 SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.41A 1ymxA-4ewfA:
31.9		 1ymxA-4ewfA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 SER A  49
LYS A  52
SER A 110
ASN A 112
LYS A 213
GLY A 215
SER A 216
 SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
SO4  A 301 (-2.4A)
 0.69A 1ymxB-4ewfA:
32.1		 1ymxB-4ewfA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.10A 2y69C-4ewfA:
undetectable
2y69N-4ewfA:
undetectable
2y69P-4ewfA:
undetectable		 2y69C-4ewfA:
21.38
2y69N-4ewfA:
20.12
2y69P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.18A 3ablC-4ewfA:
undetectable
3ablN-4ewfA:
undetectable
3ablP-4ewfA:
undetectable		 3ablC-4ewfA:
21.38
3ablN-4ewfA:
20.12
3ablP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.19A 3abmA-4ewfA:
undetectable
3abmC-4ewfA:
undetectable
3abmP-4ewfA:
undetectable		 3abmA-4ewfA:
20.12
3abmC-4ewfA:
21.38
3abmP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.16A 3asnC-4ewfA:
undetectable
3asnN-4ewfA:
undetectable
3asnP-4ewfA:
undetectable		 3asnC-4ewfA:
21.38
3asnN-4ewfA:
20.12
3asnP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.15A 3asoA-4ewfA:
undetectable
3asoC-4ewfA:
undetectable
3asoP-4ewfA:
undetectable		 3asoA-4ewfA:
20.12
3asoC-4ewfA:
21.38
3asoP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.16A 3asoC-4ewfA:
undetectable
3asoN-4ewfA:
undetectable
3asoP-4ewfA:
undetectable		 3asoC-4ewfA:
21.38
3asoN-4ewfA:
20.12
3asoP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_A_CE3A301_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 LYS A  52
SER A 110
ASN A 112
LYS A 213
GLY A 215
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.45A 3hlwA-4ewfA:
32.0		 3hlwA-4ewfA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 SER A 110
ASN A 112
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.30A 3hlwB-4ewfA:
32.2		 3hlwB-4ewfA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 LYS A  52
ASN A 112
LYS A 213
THR A 214
GLY A 215
 None
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.35A 3huoA-4ewfA:
32.0		 3huoA-4ewfA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
LYS A  52
ASN A 112
THR A 214
GLY A 215
ARG A 197
 None
SO4  A 301 (-3.1A)
None
None
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
SO4  A 301 ( 3.7A)
 0.65A 3mzeA-4ewfA:
22.5		 3mzeA-4ewfA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
ARG A 197
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 ( 3.7A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.57A 3ny4A-4ewfA:
30.5		 3ny4A-4ewfA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 LYS A  52
SER A 110
ASN A 112
LYS A 213
GLY A 215
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.38A 3q07A-4ewfA:
32.0		 3q07A-4ewfA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 LYS A  52
SER A 110
ASN A 112
LYS A 213
GLY A 215
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.56A 3q07B-4ewfA:
32.0		 3q07B-4ewfA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
SER A 110
ASN A 112
LYS A 213
THR A 214
GLY A 215
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.29A 3sh8A-4ewfA:
30.6		 3sh8A-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
LYS A  52
SER A 110
ASN A 112
LYS A 213
GLY A 215
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.31A 3sh8B-4ewfA:
30.3		 3sh8B-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
LYS A  52
SER A 110
LYS A 213
GLY A 215
ARG A 197
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
SO4  A 301 ( 3.7A)
 0.99A 3sh8B-4ewfA:
30.3		 3sh8B-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 PHE A  45
GLY A  26
ILE A  53
ALA A 165
ALA A 167
 None
 0.95A 3sufB-4ewfA:
undetectable		 3sufB-4ewfA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.14A 3wg7A-4ewfA:
undetectable
3wg7C-4ewfA:
undetectable
3wg7P-4ewfA:
undetectable		 3wg7A-4ewfA:
20.12
3wg7C-4ewfA:
21.38
3wg7P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.16A 3wg7C-4ewfA:
undetectable
3wg7N-4ewfA:
undetectable
3wg7P-4ewfA:
undetectable		 3wg7C-4ewfA:
21.38
3wg7N-4ewfA:
20.12
3wg7P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.16A 3x2qA-4ewfA:
undetectable
3x2qC-4ewfA:
undetectable
3x2qP-4ewfA:
undetectable		 3x2qA-4ewfA:
20.12
3x2qC-4ewfA:
21.38
3x2qP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.15A 3x2qC-4ewfA:
undetectable
3x2qN-4ewfA:
undetectable
3x2qP-4ewfA:
undetectable		 3x2qC-4ewfA:
21.38
3x2qN-4ewfA:
20.12
3x2qP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 LYS A  52
SER A 110
ASN A 112
LYS A 213
THR A 214
GLY A 215
 None
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.46A 4euzA-4ewfA:
31.5		 4euzA-4ewfA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		3 / 3 SER A 139
MET A 136
ASP A 125
 None
 0.97A 4mm4B-4ewfA:
undetectable		 4mm4B-4ewfA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
SER A 110
ASN A 112
LYS A 213
THR A 214
GLY A 215
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.29A 4n9kA-4ewfA:
31.0		 4n9kA-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
SER A 110
ASN A 112
THR A 214
GLY A 215
ARG A 197
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
SO4  A 301 ( 3.7A)
 1.02A 4n9kA-4ewfA:
31.0		 4n9kA-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
SER A 110
ASN A 112
LYS A 213
THR A 214
GLY A 215
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.33A 4n9kB-4ewfA:
31.1		 4n9kB-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 ALA A  48
SER A  49
SER A 110
LYS A 213
THR A 214
GLY A 215
ARG A 197
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
SO4  A 301 ( 3.7A)
 0.96A 4n9kB-4ewfA:
31.1		 4n9kB-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.14A 5b1aA-4ewfA:
undetectable
5b1aC-4ewfA:
undetectable
5b1aP-4ewfA:
undetectable		 5b1aA-4ewfA:
20.12
5b1aC-4ewfA:
21.38
5b1aP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.10A 5b3sA-4ewfA:
undetectable
5b3sC-4ewfA:
undetectable
5b3sP-4ewfA:
undetectable		 5b3sA-4ewfA:
20.12
5b3sC-4ewfA:
21.38
5b3sP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 GLY A 174
ARG A 175
GLU A 190
THR A 228
LEU A 172
 None
 1.35A 5fhzD-4ewfA:
undetectable		 5fhzD-4ewfA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 ALA A  48
SER A  49
SER A 110
ASN A 112
LYS A 213
GLY A 215
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.30A 5ghyA-4ewfA:
30.9		 5ghyA-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 ALA A  48
SER A  49
SER A 110
LYS A 213
GLY A 215
ARG A 197
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
SO4  A 301 ( 3.7A)
 0.97A 5ghyA-4ewfA:
30.9		 5ghyA-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 ALA A  48
SER A  49
SER A 110
ASN A 112
LYS A 213
GLY A 215
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
 0.29A 5ghyB-4ewfA:
30.9		 5ghyB-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 ALA A  48
SER A  49
SER A 110
LYS A 213
GLY A 215
ARG A 197
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
SO4  A 301 ( 3.7A)
 0.98A 5ghyB-4ewfA:
30.9		 5ghyB-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 11 ALA A  48
SER A  49
SER A 110
ASN A 112
LYS A 213
THR A 214
GLY A 215
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.30A 5ghzA-4ewfA:
31.1		 5ghzA-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 11 ALA A  48
SER A  49
SER A 110
ASN A 112
THR A 214
GLY A 215
ARG A 197
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
SO4  A 301 ( 3.7A)
 1.03A 5ghzA-4ewfA:
31.1		 5ghzA-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 10 ALA A  48
SER A  49
SER A 110
ASN A 112
LYS A 213
THR A 214
GLY A 215
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.29A 5ghzB-4ewfA:
31.0		 5ghzB-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 10 ALA A  48
SER A  49
SER A 110
ASN A 112
THR A 214
GLY A 215
ARG A 197
 None
SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
SO4  A 301 ( 3.7A)
 1.03A 5ghzB-4ewfA:
31.0		 5ghzB-4ewfA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 GLY A 254
VAL A 236
ALA A 252
ALA A 248
VAL A 221
 None
 1.12A 5n0oB-4ewfA:
undetectable		 5n0oB-4ewfA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 7 GLN A 169
LEU A 166
ASP A 163
ALA A 159
 None
 1.08A 5nwvA-4ewfA:
undetectable		 5nwvA-4ewfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.18A 5wauA-4ewfA:
undetectable
5wauC-4ewfA:
undetectable
5wauc-4ewfA:
undetectable		 5wauA-4ewfA:
20.12
5wauC-4ewfA:
21.38
5wauc-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 7 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.21A 5wauC-4ewfA:
undetectable
5waua-4ewfA:
undetectable
5wauc-4ewfA:
undetectable		 5wauC-4ewfA:
21.38
5waua-4ewfA:
20.12
5wauc-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.18A 5xdqA-4ewfA:
undetectable
5xdqC-4ewfA:
undetectable
5xdqP-4ewfA:
undetectable		 5xdqA-4ewfA:
20.12
5xdqC-4ewfA:
21.38
5xdqP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.16A 5xdqC-4ewfA:
undetectable
5xdqN-4ewfA:
undetectable
5xdqP-4ewfA:
undetectable		 5xdqC-4ewfA:
21.38
5xdqN-4ewfA:
20.12
5xdqP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.18A 5xdxC-4ewfA:
undetectable
5xdxN-4ewfA:
undetectable
5xdxP-4ewfA:
undetectable		 5xdxC-4ewfA:
20.46
5xdxN-4ewfA:
20.12
5xdxP-4ewfA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.16A 5z84A-4ewfA:
undetectable
5z84C-4ewfA:
undetectable
5z84P-4ewfA:
undetectable		 5z84A-4ewfA:
20.12
5z84C-4ewfA:
21.38
5z84P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 7 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.19A 5z84C-4ewfA:
undetectable
5z84N-4ewfA:
undetectable
5z84P-4ewfA:
undetectable		 5z84C-4ewfA:
21.38
5z84N-4ewfA:
20.12
5z84P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.13A 5z85A-4ewfA:
undetectable
5z85C-4ewfA:
undetectable
5z85P-4ewfA:
undetectable		 5z85A-4ewfA:
20.12
5z85C-4ewfA:
21.38
5z85P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 7 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.18A 5z85C-4ewfA:
undetectable
5z85N-4ewfA:
undetectable
5z85P-4ewfA:
undetectable		 5z85C-4ewfA:
21.38
5z85N-4ewfA:
20.12
5z85P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.14A 5z86A-4ewfA:
undetectable
5z86C-4ewfA:
undetectable
5z86P-4ewfA:
undetectable		 5z86A-4ewfA:
20.12
5z86C-4ewfA:
21.38
5z86P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.18A 5z86C-4ewfA:
undetectable
5z86N-4ewfA:
undetectable
5z86P-4ewfA:
undetectable		 5z86C-4ewfA:
21.38
5z86N-4ewfA:
20.12
5z86P-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.15A 5zcoA-4ewfA:
undetectable
5zcoC-4ewfA:
undetectable
5zcoP-4ewfA:
undetectable		 5zcoA-4ewfA:
20.12
5zcoC-4ewfA:
21.38
5zcoP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.17A 5zcoC-4ewfA:
undetectable
5zcoN-4ewfA:
undetectable
5zcoP-4ewfA:
undetectable		 5zcoC-4ewfA:
21.38
5zcoN-4ewfA:
20.12
5zcoP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.16A 5zcpA-4ewfA:
undetectable
5zcpC-4ewfA:
undetectable
5zcpP-4ewfA:
undetectable		 5zcpA-4ewfA:
20.12
5zcpC-4ewfA:
21.38
5zcpP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 166
ASP A 162
THR A 160
TYR A 164
 None
 1.21A 5zcpC-4ewfA:
undetectable
5zcpN-4ewfA:
undetectable
5zcpP-4ewfA:
undetectable		 5zcpC-4ewfA:
21.38
5zcpN-4ewfA:
20.12
5zcpP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		4 / 8 ASP A 162
THR A 160
TYR A 164
LEU A 166
 None
 1.12A 5zcqA-4ewfA:
undetectable
5zcqC-4ewfA:
undetectable
5zcqP-4ewfA:
undetectable		 5zcqA-4ewfA:
20.12
5zcqC-4ewfA:
21.38
5zcqP-4ewfA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
ARG A 197
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 ( 3.7A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.42A 6b5yB-4ewfA:
30.7		 6b5yB-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
LYS A 213
THR A 214
GLY A 215
GLU A 250
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
None
 0.52A 6b5yD-4ewfA:
30.8		 6b5yD-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
ARG A 148
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.66A 6b68B-4ewfA:
30.7		 6b68B-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
ARG A 197
LYS A 213
GLY A 215
GLU A 250
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 ( 3.7A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
None
 0.33A 6b68D-4ewfA:
30.8		 6b68D-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 SER A  49
SER A 110
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.28A 6b69A-4ewfA:
30.8
6b69B-4ewfA:
30.8		 6b69A-4ewfA:
15.45
6b69B-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 SER A  49
SER A 110
ARG A 197
LYS A 213
THR A 214
GLY A 215
GLU A 250
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 ( 3.7A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
None
 0.30A 6b69D-4ewfA:
30.7		 6b69D-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
ARG A 197
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 ( 3.7A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.31A 6b6aB-4ewfA:
30.7		 6b6aB-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		7 / 12 SER A  49
SER A 110
ARG A 197
LYS A 213
THR A 214
GLY A 215
GLU A 250
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 ( 3.7A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
None
 0.32A 6b6aD-4ewfA:
30.8		 6b6aD-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
ARG A 148
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.94A 6b6cA-4ewfA:
30.6		 6b6cA-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
ARG A 197
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 ( 3.7A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.37A 6b6cA-4ewfA:
30.6		 6b6cA-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
ARG A 148
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.82A 6b6eA-4ewfA:
30.4		 6b6eA-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		6 / 12 SER A  49
SER A 110
ARG A 197
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 ( 3.7A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.38A 6b6eA-4ewfA:
30.4		 6b6eA-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 SER A  49
SER A 110
LYS A 213
THR A 214
GLY A 215
 SO4  A 301 (-3.1A)
SO4  A 301 (-3.1A)
SO4  A 301 (-3.0A)
SO4  A 301 (-3.8A)
SO4  A 301 (-3.5A)
 0.48A 6b6fA-4ewfA:
30.5		 6b6fA-4ewfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 4ewf BETA-LACTAMASE
(Sphaerobacter
thermophilus) 		5 / 12 SER A 110
ASN A 112
LYS A 213
GLY A 215
SER A 216
 SO4  A 301 (-3.1A)
None
SO4  A 301 (-3.0A)
SO4  A 301 (-3.5A)
SO4  A 301 (-2.4A)
 0.66A 6c79A-4ewfA:
32.2		 6c79A-4ewfA:
22.84