SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ewg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 8 ASP A 306
GLY A 302
SER A 313
ASP A 367
 None
 0.90A 1m4iA-4ewgA:
undetectable		 1m4iA-4ewgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 7 ILE A 178
GLU A 242
ARG A 249
ALA A 246
 None
 1.02A 1oniD-4ewgA:
undetectable
1oniE-4ewgA:
undetectable		 1oniD-4ewgA:
18.38
1oniE-4ewgA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 11 GLY A 167
ALA A 170
ALA A 174
LEU A 240
VAL A 158
 None
 1.12A 1ukbA-4ewgA:
undetectable		 1ukbA-4ewgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 11 VAL A 239
GLY A   8
LEU A 185
ARG A 100
SER A  95
 None
 1.21A 2bxgA-4ewgA:
undetectable		 2bxgA-4ewgA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 12 GLY A 259
ALA A 284
GLY A 261
LEU A 290
LEU A 285
 None
 1.00A 2nyuA-4ewgA:
undetectable		 2nyuA-4ewgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 12 GLY A 259
ALA A 284
GLY A 261
LEU A 290
LEU A 285
 None
 0.97A 2nyuB-4ewgA:
undetectable		 2nyuB-4ewgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 163
GLY A 341
CYH A 340
HIS A 335
 None
 1.18A 2yldA-4ewgA:
undetectable		 2yldA-4ewgA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 394
GLY A 341
CYH A 340
HIS A 335
 None
 1.28A 2yldA-4ewgA:
undetectable		 2yldA-4ewgA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 163
GLY A 341
CYH A 340
HIS A 335
 None
 1.20A 2ylgA-4ewgA:
undetectable		 2ylgA-4ewgA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 394
GLY A 341
CYH A 340
HIS A 335
 None
 1.27A 2ylgA-4ewgA:
undetectable		 2ylgA-4ewgA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 8 SER A  74
VAL A 147
VAL A  73
VAL A 103
 None
 1.10A 3fhxB-4ewgA:
undetectable		 3fhxB-4ewgA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 11 LEU A 187
LEU A 185
GLU A 241
ARG A 249
GLY A  10
 None
 1.15A 3hm1B-4ewgA:
undetectable		 3hm1B-4ewgA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 10 PRO A 359
ARG A 220
ASN A 362
GLY A  29
TYR A 332
 None
 1.41A 3pp7B-4ewgA:
undetectable		 3pp7B-4ewgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 163
GLY A 341
CYH A 340
HIS A 335
 None
 1.18A 3zwiA-4ewgA:
undetectable		 3zwiA-4ewgA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 394
GLY A 341
CYH A 340
HIS A 335
 None
 1.28A 3zwiA-4ewgA:
undetectable		 3zwiA-4ewgA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 7 GLU A 193
GLU A 192
HIS A 141
VAL A 103
 None
 1.06A 4a97A-4ewgA:
undetectable		 4a97A-4ewgA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 4 ALA A 163
GLY A 341
CYH A 340
HIS A 335
 None
 1.16A 4cipA-4ewgA:
undetectable		 4cipA-4ewgA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 4 ALA A 394
GLY A 341
CYH A 340
HIS A 335
 None
 1.28A 4cipA-4ewgA:
undetectable		 4cipA-4ewgA:
17.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		8 / 12 ALA A 163
CYH A 164
GLU A 192
HIS A 301
THR A 303
HIS A 335
LEU A 337
PHE A 395
 None
 0.74A 4ls7A-4ewgA:
59.0		 4ls7A-4ewgA:
38.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		7 / 12 ALA A 163
CYH A 164
HIS A 301
THR A 303
HIS A 335
LEU A 337
PHE A 395
 None
 0.73A 4ls7A-4ewgA:
59.0
4ls7B-4ewgA:
58.6		 4ls7A-4ewgA:
38.27
4ls7B-4ewgA:
38.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 11 ASP A 367
ALA A 369
ASP A 227
GLY A 308
GLY A 228
 None
 1.21A 4xp4A-4ewgA:
undetectable		 4xp4A-4ewgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 10 SER A 162
SER A 161
LEU A 402
SER A 107
LEU A 238
 None
 1.21A 4yiaA-4ewgA:
undetectable		 4yiaA-4ewgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 7 CYH A 340
LYS A 330
GLY A 302
HIS A 335
 None
 1.03A 5a5zC-4ewgA:
undetectable		 5a5zC-4ewgA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 12 VAL A 258
PHE A 404
LEU A 373
MET A 281
ALA A 278
 None
 1.43A 5fctB-4ewgA:
undetectable		 5fctB-4ewgA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		6 / 12 LEU A 402
ILE A   6
TYR A 105
THR A 160
ALA A 104
LEU A 240
 None
 1.19A 5ienB-4ewgA:
undetectable		 5ienB-4ewgA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		3 / 3 LEU A 329
TYR A 297
SER A 390
 None
 0.83A 5iktA-4ewgA:
undetectable		 5iktA-4ewgA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 163
GLY A 341
CYH A 340
HIS A 335
 None
 1.17A 5jliA-4ewgA:
undetectable		 5jliA-4ewgA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 394
GLY A 341
CYH A 340
HIS A 335
 None
 1.26A 5jliA-4ewgA:
undetectable		 5jliA-4ewgA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSL_A_ASCA202_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 4 ALA A 163
GLY A 341
CYH A 340
HIS A 335
 None
 1.21A 5jslA-4ewgA:
undetectable		 5jslA-4ewgA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSL_A_ASCA202_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 4 ALA A 394
GLY A 341
CYH A 340
HIS A 335
 None
 1.30A 5jslA-4ewgA:
undetectable		 5jslA-4ewgA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 163
GLY A 341
CYH A 340
HIS A 335
 None
 1.20A 5jt4A-4ewgA:
undetectable		 5jt4A-4ewgA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 5 ALA A 394
GLY A 341
CYH A 340
HIS A 335
 None
 1.27A 5jt4A-4ewgA:
undetectable		 5jt4A-4ewgA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		3 / 3 PHE A  90
ARG A 100
ALA A 248
 None
 0.90A 6ecfB-4ewgA:
undetectable		 6ecfB-4ewgA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 8 ILE A  22
ARG A 354
TRP A 356
TYR A 357
 None
 1.24A 6hisA-4ewgA:
undetectable
6hisB-4ewgA:
undetectable		 6hisA-4ewgA:
11.59
6hisB-4ewgA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 8 ILE A  22
ARG A 354
TRP A 356
TYR A 357
 None
 1.24A 6hisB-4ewgA:
undetectable
6hisC-4ewgA:
undetectable		 6hisB-4ewgA:
11.59
6hisC-4ewgA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 8 ILE A  22
ARG A 354
TRP A 356
TYR A 357
 None
 1.25A 6hisD-4ewgA:
undetectable
6hisE-4ewgA:
undetectable		 6hisD-4ewgA:
11.59
6hisE-4ewgA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		5 / 11 SER A 327
TYR A 332
VAL A 333
GLY A 232
ALA A 198
 None
 1.31A 6hu9A-4ewgA:
0.0
6hu9E-4ewgA:
undetectable
6hu9I-4ewgA:
undetectable		 6hu9A-4ewgA:
21.95
6hu9E-4ewgA:
20.00
6hu9I-4ewgA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ewg BETA-KETOACYL
SYNTHASE
(Paraburkholderia
phymatum) 		4 / 6 ARG A  48
PHE A 202
LEU A  45
PHE A  42
 None
 1.29A 6nmpC-4ewgA:
undetectable
6nmpJ-4ewgA:
undetectable		 6nmpC-4ewgA:
19.76
6nmpJ-4ewgA:
8.17