SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ewj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 5 ARG A  52
LYS A  66
ALA A  67
GLY A 107
 None
 0.99A 1e7cA-4ewjA:
undetectable		 1e7cA-4ewjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 6 GLU A  50
THR A  64
ALA A  67
LEU A 106
 None
 1.06A 1etb2-4ewjA:
undetectable		 1etb2-4ewjA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 8 ASP A 320
GLU A 292
GLY A 318
SER A 371
 None
 0.87A 1m4iA-4ewjA:
undetectable		 1m4iA-4ewjA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4ewj ENOLASE 2
(Streptococcus
suis) 		3 / 3 ASP A 403
ARG A 401
ASP A  14
 None
 0.89A 1vptA-4ewjA:
undetectable		 1vptA-4ewjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 4 LEU A 279
SER A 246
LEU A 316
LEU A 306
 None
 0.84A 1yajA-4ewjA:
undetectable		 1yajA-4ewjA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 12 VAL A  68
ALA A  76
GLU A  24
THR A  20
THR A  64
 None
 1.24A 3dl9B-4ewjA:
undetectable		 3dl9B-4ewjA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 7 VAL A  23
ILE A  90
THR A 352
GLY A 113
 None
 0.97A 3gssA-4ewjA:
undetectable		 3gssA-4ewjA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 4 ASP A 296
ASP A 299
GLY A 294
THR A 307
 None
 1.23A 3tl9B-4ewjA:
undetectable		 3tl9B-4ewjA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 8 LEU A 198
ASN A 151
GLY A 152
ILE A 160
 None
 0.80A 3wxoA-4ewjA:
undetectable		 3wxoA-4ewjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 8 ALA A 161
THR A 215
LEU A 282
LEU A 279
 None
 0.88A 4ejgB-4ewjA:
undetectable		 4ejgB-4ewjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 7 SER A 340
PHE A 322
ASN A 339
TRP A 303
 None
 1.43A 4kcnB-4ewjA:
undetectable		 4kcnB-4ewjA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 8 PHE A 355
THR A 389
LEU A 130
VAL A 370
 None
 1.13A 4l4eA-4ewjA:
undetectable		 4l4eA-4ewjA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 8 PHE A 355
THR A 389
LEU A 130
VAL A 370
 None
 1.14A 4l4fA-4ewjA:
undetectable		 4l4fA-4ewjA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 11 ASP A  86
VAL A  25
ALA A 117
SER A 115
THR A  27
 None
 1.30A 4mmaA-4ewjA:
undetectable		 4mmaA-4ewjA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 5 LEU A 142
SER A 174
LEU A 412
LEU A 418
 None
 1.28A 4n09B-4ewjA:
undetectable		 4n09B-4ewjA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 5 LEU A 142
SER A 174
LEU A 412
LEU A 418
 None
 1.27A 4n09D-4ewjA:
undetectable		 4n09D-4ewjA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4ewj ENOLASE 2
(Streptococcus
suis) 		6 / 12 GLY A 107
GLY A 104
LEU A 112
ASN A 109
ILE A 348
THR A 354
 None
 1.43A 4n49A-4ewjA:
undetectable		 4n49A-4ewjA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 6 LEU A 351
ASP A 379
VAL A 387
ALA A 386
 None
 1.15A 4nkvC-4ewjA:
undetectable		 4nkvC-4ewjA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 12 LEU A 112
THR A 381
ILE A 385
GLN A  87
THR A 354
 None
 1.12A 4o5fA-4ewjA:
undetectable
4o5fB-4ewjA:
undetectable		 4o5fA-4ewjA:
22.03
4o5fB-4ewjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 12 GLN A  87
THR A 354
LEU A 112
THR A 381
ILE A 385
 None
 1.15A 4o5fA-4ewjA:
undetectable
4o5fB-4ewjA:
undetectable		 4o5fA-4ewjA:
22.03
4o5fB-4ewjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 12 PHE A 355
GLU A 359
ALA A 364
GLY A 365
TYR A 431
 None
 1.46A 4oadA-4ewjA:
undetectable		 4oadA-4ewjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4ewj ENOLASE 2
(Streptococcus
suis) 		3 / 3 ARG A  92
GLN A  88
GLU A 356
 None
 0.78A 4tvtA-4ewjA:
undetectable		 4tvtA-4ewjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 12 LEU A 112
THR A 381
ILE A 385
GLN A  87
THR A 354
 None
 1.17A 5b8hA-4ewjA:
undetectable
5b8hB-4ewjA:
undetectable		 5b8hA-4ewjA:
22.13
5b8hB-4ewjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 12 GLN A  87
THR A 354
LEU A 112
THR A 381
ILE A 385
 None
 1.19A 5b8hA-4ewjA:
undetectable
5b8hB-4ewjA:
undetectable		 5b8hA-4ewjA:
22.13
5b8hB-4ewjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 6 TYR A 408
GLY A 206
SER A 400
LEU A 399
 None
 1.28A 5bphD-4ewjA:
undetectable		 5bphD-4ewjA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 11 THR A  64
GLN A  65
ALA A 108
GLY A 107
ALA A 110
 None
 1.30A 5bxnV-4ewjA:
undetectable
5bxnW-4ewjA:
undetectable		 5bxnV-4ewjA:
18.57
5bxnW-4ewjA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 5 TYR A 231
ILE A 226
LEU A 179
GLY A 178
 None
 0.90A 5kmdC-4ewjA:
undetectable
5kmdD-4ewjA:
undetectable		 5kmdC-4ewjA:
20.67
5kmdD-4ewjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4ewj ENOLASE 2
(Streptococcus
suis) 		3 / 3 THR A  20
THR A  64
ARG A  52
 None
 0.98A 5wm2A-4ewjA:
undetectable		 5wm2A-4ewjA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 4ewj ENOLASE 2
(Streptococcus
suis) 		4 / 5 MET A 146
ASN A 428
VAL A 170
LEU A 168
 None
 1.36A 5xdhD-4ewjA:
undetectable		 5xdhD-4ewjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 11 GLY A 214
TYR A 278
VAL A 219
PHE A 242
GLY A 218
 None
 1.12A 5yjsA-4ewjA:
undetectable		 5yjsA-4ewjA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 12 PHE A 430
GLY A 237
GLY A 171
TYR A 231
ILE A 226
 None
 0.98A 6b3aA-4ewjA:
undetectable		 6b3aA-4ewjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4ewj ENOLASE 2
(Streptococcus
suis) 		5 / 12 PHE A 430
GLY A 237
GLY A 171
TYR A 231
ILE A 226
 None
 0.98A 6b3bA-4ewjA:
undetectable		 6b3bA-4ewjA:
21.67