SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ewl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  13
HIS A 144
HIS A 147
ASP A  16
ASP A  15
 ZN  A 403 (-3.1A)
GOL  A 405 (-4.0A)
ZN  A 403 ( 3.3A)
ZN  A 403 ( 1.9A)
ACT  A 404 (-3.0A)
 1.27A 1a4lA-4ewlA:
undetectable		 1a4lA-4ewlA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  13
HIS A 144
HIS A 147
ASP A  16
ASP A  15
 ZN  A 403 (-3.1A)
GOL  A 405 (-4.0A)
ZN  A 403 ( 3.3A)
ZN  A 403 ( 1.9A)
ACT  A 404 (-3.0A)
 1.28A 1a4lC-4ewlA:
undetectable		 1a4lC-4ewlA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
LEU A  76
VAL A  37
ALA A 239
SER A  20
 None
 1.11A 1dfoB-4ewlA:
undetectable		 1dfoB-4ewlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
LEU A  76
VAL A  37
ALA A 239
SER A  20
 None
 1.11A 1dfoD-4ewlA:
undetectable		 1dfoD-4ewlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		4 / 5 THR A  41
ASP A 146
HIS A 144
HIS A  13
 None
None
GOL  A 405 (-4.0A)
ZN  A 403 (-3.1A)
 1.16A 1ei6A-4ewlA:
undetectable		 1ei6A-4ewlA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
LEU A  76
VAL A  37
ALA A 239
SER A  20
 None
 1.09A 1eqbA-4ewlA:
undetectable		 1eqbA-4ewlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
LEU A  76
VAL A  37
ALA A 239
SER A  20
 None
 1.10A 1eqbB-4ewlA:
undetectable		 1eqbB-4ewlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
LEU A  76
VAL A  37
ALA A 239
SER A  20
 None
 1.10A 1eqbC-4ewlA:
undetectable		 1eqbC-4ewlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
LEU A  76
VAL A  37
ALA A 239
SER A  20
 None
 1.11A 1eqbD-4ewlA:
undetectable		 1eqbD-4ewlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		4 / 8 PHE A   9
THR A 183
VAL A 227
ILE A  25
 None
 0.92A 2qbmA-4ewlA:
undetectable		 2qbmA-4ewlA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 8 HIS A  13
ARG A  68
ASP A  95
HIS A 144
ASP A 146
 ZN  A 403 (-3.1A)
GOL  A 405 (-3.3A)
GOL  A 405 (-2.8A)
GOL  A 405 (-4.0A)
None
 0.48A 2xadA-4ewlA:
18.0		 2xadA-4ewlA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 8 HIS A  13
ARG A  68
ASP A  95
HIS A 144
ASP A 146
 ZN  A 403 (-3.1A)
GOL  A 405 (-3.3A)
GOL  A 405 (-2.8A)
GOL  A 405 (-4.0A)
None
 0.48A 2xadB-4ewlA:
18.1		 2xadB-4ewlA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 8 HIS A  13
ARG A  68
ASP A  95
HIS A 144
ASP A 146
 ZN  A 403 (-3.1A)
GOL  A 405 (-3.3A)
GOL  A 405 (-2.8A)
GOL  A 405 (-4.0A)
None
 0.48A 2xadC-4ewlA:
17.7		 2xadC-4ewlA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 8 HIS A  13
ARG A  68
ASP A  95
HIS A 144
ASP A 146
 ZN  A 403 (-3.1A)
GOL  A 405 (-3.3A)
GOL  A 405 (-2.8A)
GOL  A 405 (-4.0A)
None
 0.48A 2xadD-4ewlA:
17.9		 2xadD-4ewlA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 150
VAL A 153
THR A 154
THR A 135
 None
 0.73A 3deuA-4ewlA:
undetectable		 3deuA-4ewlA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 132
TYR A  28
TYR A 181
GLU A 289
 None
 0.90A 3q5sA-4ewlA:
undetectable		 3q5sA-4ewlA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		4 / 9 PHE A 109
CYH A  40
HIS A 149
ILE A 124
 None
 1.30A 4jvlA-4ewlA:
undetectable		 4jvlA-4ewlA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A  43
THR A  41
GLY A  97
GLU A  44
 GOL  A 405 (-3.5A)
None
GOL  A 405 (-3.6A)
None
 0.93A 4v20A-4ewlA:
undetectable		 4v20A-4ewlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 227
LEU A  79
VAL A  35
VAL A  37
PHE A   9
 None
None
GOL  A 402 (-4.4A)
None
None
 0.97A 4y0pA-4ewlA:
undetectable		 4y0pA-4ewlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 227
LEU A  79
VAL A  35
VAL A  37
PHE A   9
 None
None
GOL  A 402 (-4.4A)
None
None
 0.99A 4y0sA-4ewlA:
undetectable		 4y0sA-4ewlA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  45
ASP A 146
PRO A 145
 None
 0.72A 6berA-4ewlA:
undetectable		 6berA-4ewlA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 147
LEU A  72
TYR A  86
GLY A  43
 ZN  A 403 ( 3.3A)
None
None
GOL  A 405 (-3.5A)
 1.16A 6n91A-4ewlA:
undetectable		 6n91A-4ewlA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 147
LEU A  72
TYR A  86
GLY A  43
 ZN  A 403 ( 3.3A)
None
None
GOL  A 405 (-3.5A)
 1.15A 6n91B-4ewlA:
undetectable		 6n91B-4ewlA:
14.29