SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ewp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 5 HIS A 107
GLU A 108
ALA A 102
SER A 100
 None
 1.22A 1errA-4ewpA:
undetectable
1errB-4ewpA:
undetectable		 1errA-4ewpA:
20.81
1errB-4ewpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		3 / 3 VAL A 148
ALA A 174
HIS A 317
 None
 0.69A 1q23C-4ewpA:
undetectable		 1q23C-4ewpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 4 ALA A  69
VAL A 148
ALA A 174
HIS A 317
 None
 1.18A 1q23A-4ewpA:
undetectable		 1q23A-4ewpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 4 ALA A 172
VAL A 148
ALA A 174
HIS A 317
 None
 0.91A 1q23A-4ewpA:
undetectable		 1q23A-4ewpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		3 / 3 VAL A 148
ALA A 174
HIS A 317
 None
 0.67A 1q23H-4ewpA:
undetectable		 1q23H-4ewpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		3 / 3 VAL A 148
ALA A 174
HIS A 317
 None
 0.68A 1q23L-4ewpA:
undetectable		 1q23L-4ewpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 GLY A 149
GLY A 125
ILE A 176
LEU A  84
VAL A 119
 None
 1.04A 2hmyB-4ewpA:
undetectable		 2hmyB-4ewpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		3 / 3 THR A  61
ASP A 118
SER A 120
 None
 0.83A 2nxeA-4ewpA:
undetectable		 2nxeA-4ewpA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 LEU A 168
ASN A 306
ALA A 122
VAL A  62
ILE A 164
 None
 1.09A 3czhB-4ewpA:
undetectable		 3czhB-4ewpA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 6 VAL A  17
LEU A 319
MET A 316
ILE A 176
 None
 0.92A 3gcsA-4ewpA:
undetectable		 3gcsA-4ewpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 10 VAL A 150
VAL A 148
LEU A 146
GLY A 173
GLY A  20
 None
 1.22A 3ls4H-4ewpA:
undetectable		 3ls4H-4ewpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 TYR A 126
ALA A 174
SER A  90
LEU A 146
ALA A  21
 None
 1.22A 3ou6C-4ewpA:
undetectable		 3ou6C-4ewpA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 TYR A 126
ALA A 174
SER A  90
LEU A 146
ALA A  21
 None
 1.23A 3ou7C-4ewpA:
undetectable		 3ou7C-4ewpA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 8 TYR A 128
TRP A 190
VAL A 189
TYR A 342
 None
 1.30A 4bqtC-4ewpA:
undetectable
4bqtD-4ewpA:
undetectable		 4bqtC-4ewpA:
19.19
4bqtD-4ewpA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 6 ALA A  25
ASN A  26
LEU A  27
VAL A  28
 None
 0.83A 4g24A-4ewpA:
undetectable		 4g24A-4ewpA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 7 ARG A  23
ALA A 315
ARG A  53
GLY A 169
 None
 0.88A 5bs8A-4ewpA:
undetectable
5bs8C-4ewpA:
undetectable
5bs8D-4ewpA:
undetectable		 5bs8A-4ewpA:
25.51
5bs8C-4ewpA:
25.51
5bs8D-4ewpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 6 ALA A 315
ARG A  53
GLY A 169
ARG A  23
 None
 0.88A 5btgA-4ewpA:
undetectable
5btgB-4ewpA:
undetectable
5btgC-4ewpA:
undetectable		 5btgA-4ewpA:
25.51
5btgB-4ewpA:
21.86
5btgC-4ewpA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 7 ARG A  23
ALA A 315
ARG A  53
GLY A 169
 None
 0.91A 5btgA-4ewpA:
undetectable
5btgC-4ewpA:
undetectable
5btgD-4ewpA:
undetectable		 5btgA-4ewpA:
25.51
5btgC-4ewpA:
25.51
5btgD-4ewpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 PRO A  24
VAL A 148
VAL A  62
TYR A  22
LEU A 314
 None
 1.50A 5cymA-4ewpA:
undetectable		 5cymA-4ewpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 PRO A  24
VAL A 148
VAL A  62
TYR A  22
LEU A 314
 None
 1.48A 5cyqA-4ewpA:
undetectable		 5cyqA-4ewpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 8 SER A 311
ALA A 310
HIS A 275
LEU A 168
 None
 1.04A 5dzkd-4ewpA:
undetectable
5dzkr-4ewpA:
undetectable		 5dzkd-4ewpA:
21.31
5dzkr-4ewpA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		4 / 8 SER A 311
ALA A 310
HIS A 275
LEU A 168
 None
 1.03A 5dzkF-4ewpA:
undetectable
5dzkT-4ewpA:
undetectable		 5dzkF-4ewpA:
21.31
5dzkT-4ewpA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 ALA A 102
PRO A 313
GLY A 149
THR A 307
TYR A 126
 None
 1.20A 5hfjE-4ewpA:
undetectable		 5hfjE-4ewpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 ARG A 256
LEU A 289
PHE A 285
ARG A 280
ASN A 278
 None
 1.23A 5il1A-4ewpA:
undetectable		 5il1A-4ewpA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 GLY A 140
HIS A   8
VAL A 147
VAL A 145
ASP A  85
 None
 1.31A 6bxlB-4ewpA:
1.8		 6bxlB-4ewpA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 12 PRO A  24
VAL A 148
VAL A  62
TYR A  22
LEU A 314
 None
 1.49A 6eliA-4ewpA:
undetectable		 6eliA-4ewpA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 11 VAL A 347
GLY A 184
SER A 180
ALA A  12
VAL A  17
 None
 1.39A 6hu9A-4ewpA:
undetectable
6hu9E-4ewpA:
undetectable
6hu9I-4ewpA:
undetectable		 6hu9A-4ewpA:
21.19
6hu9E-4ewpA:
20.52
6hu9I-4ewpA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Micrococcus
luteus) 		5 / 10 VAL A 347
GLY A 184
SER A 180
ALA A  12
VAL A  17
 None
 1.38A 6hu9L-4ewpA:
undetectable
6hu9P-4ewpA:
undetectable
6hu9T-4ewpA:
undetectable		 6hu9L-4ewpA:
21.19
6hu9P-4ewpA:
20.52
6hu9T-4ewpA:
12.32