SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ewt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 12 HIS A 108
PHE A 346
MET A 166
GLU A 139
ASP A  78
 None
None
None
MN  A 401 ( 2.2A)
MN  A 402 ( 4.4A)
 1.36A 1a4lB-4ewtA:
undetectable		 1a4lB-4ewtA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 12 HIS A 108
PHE A 346
MET A 166
GLU A 139
ASP A  78
 None
None
None
MN  A 401 ( 2.2A)
MN  A 402 ( 4.4A)
 1.35A 1a4lD-4ewtA:
undetectable		 1a4lD-4ewtA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		3 / 3 ASP A 296
ASP A 258
ASP A 334
 None
 0.78A 1eizA-4ewtA:
undetectable		 1eizA-4ewtA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		3 / 3 ASP A 296
ASP A 258
ASP A 334
 None
 0.78A 1ej0A-4ewtA:
undetectable		 1ej0A-4ewtA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 11 HIS A 362
LEU A  82
PRO A  83
ALA A 102
GLY A 104
 MN  A 401 (-3.7A)
None
None
None
None
 1.36A 1mjqA-4ewtA:
undetectable
1mjqB-4ewtA:
undetectable		 1mjqA-4ewtA:
13.70
1mjqB-4ewtA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 10 HIS A 362
LEU A  82
PRO A  83
ALA A 102
GLY A 104
 MN  A 401 (-3.7A)
None
None
None
None
 1.34A 1mjqC-4ewtA:
undetectable
1mjqD-4ewtA:
undetectable		 1mjqC-4ewtA:
13.70
1mjqD-4ewtA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 11 HIS A 362
LEU A  82
PRO A  83
ALA A 102
GLY A 104
 MN  A 401 (-3.7A)
None
None
None
None
 1.35A 1mjqI-4ewtA:
undetectable
1mjqJ-4ewtA:
undetectable		 1mjqI-4ewtA:
13.70
1mjqJ-4ewtA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		3 / 3 PRO A 142
ASP A 296
ASP A 334
 None
 0.76A 1sqfA-4ewtA:
undetectable		 1sqfA-4ewtA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 7 GLU A 282
ALA A 208
ASN A 206
ALA A 211
 None
None
PEG  A 403 (-3.9A)
None
 1.04A 2ejfA-4ewtA:
4.2		 2ejfA-4ewtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 8 VAL A  55
ASN A  54
PHE A  79
ALA A  37
 None
 0.88A 2ij7C-4ewtA:
undetectable		 2ij7C-4ewtA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 4 PRO A 142
ASP A 296
ASP A 258
ASP A 334
 None
 1.45A 2nyuA-4ewtA:
undetectable		 2nyuA-4ewtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 12 SER A 369
PHE A 366
HIS A 361
THR A 171
ILE A 358
 None
 1.45A 2o7oA-4ewtA:
0.9		 2o7oA-4ewtA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 7 GLU A 282
ALA A 208
ASN A 206
ALA A 211
 None
None
PEG  A 403 (-3.9A)
None
 1.09A 2zgwA-4ewtA:
4.0		 2zgwA-4ewtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 6 GLU A 282
ALA A 208
ASN A 206
ALA A 211
 None
None
PEG  A 403 (-3.9A)
None
 1.09A 2zgwB-4ewtA:
3.7		 2zgwB-4ewtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 8 TYR A 293
ASN A 294
PRO A 142
PHE A  31
 None
 1.48A 3bjwD-4ewtA:
undetectable		 3bjwD-4ewtA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 8 TYR A  44
PHE A  43
GLY A 162
ILE A  75
 None
 0.84A 3ihzB-4ewtA:
undetectable		 3ihzB-4ewtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		3 / 3 HIS A 164
HIS A 361
MET A 166
 MN  A 402 (-3.5A)
None
None
 1.01A 3mihA-4ewtA:
undetectable		 3mihA-4ewtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 11 LEU A 277
LEU A 281
GLY A 212
LEU A 219
LEU A 190
 None
 1.30A 3ndvA-4ewtA:
undetectable
3ndvB-4ewtA:
undetectable		 3ndvA-4ewtA:
24.58
3ndvB-4ewtA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 11 GLY A 212
LEU A 219
LEU A 190
LEU A 277
LEU A 281
 None
 1.31A 3ndvC-4ewtA:
undetectable
3ndvD-4ewtA:
undetectable		 3ndvC-4ewtA:
24.58
3ndvD-4ewtA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 9 TYR A 309
ALA A 317
LEU A 314
LEU A 161
ALA A 345
 None
 0.96A 3ozvB-4ewtA:
undetectable		 3ozvB-4ewtA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 8 VAL A 165
HIS A 108
PHE A 366
PRO A 331
 None
 1.30A 3v35A-4ewtA:
undetectable		 3v35A-4ewtA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 8 TYR A 111
LEU A 119
VAL A 384
VAL A 380
 None
 0.97A 4em2A-4ewtA:
undetectable		 4em2A-4ewtA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 12 PHE A 321
VAL A 174
ALA A 379
GLU A 316
ALA A 317
 None
 1.08A 4fiaA-4ewtA:
undetectable		 4fiaA-4ewtA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 12 PHE A 321
VAL A 174
ALA A 379
GLU A 316
THR A 313
 None
 1.26A 4fiaA-4ewtA:
undetectable		 4fiaA-4ewtA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 12 PHE A 321
VAL A 174
ALA A 379
GLU A 316
ALA A 317
 None
 1.08A 4fiaA-4ewtA:
undetectable		 4fiaA-4ewtA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 12 PHE A 321
VAL A 174
ALA A 379
GLU A 316
THR A 313
 None
 1.26A 4fiaA-4ewtA:
undetectable		 4fiaA-4ewtA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		3 / 3 SER A 332
ASP A  78
ASP A 106
 None
MN  A 402 ( 4.4A)
None
 0.51A 4mwzA-4ewtA:
undetectable		 4mwzA-4ewtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 7 PHE A  79
HIS A 134
ILE A  60
TYR A  44
 None
 1.43A 4o7gA-4ewtA:
undetectable
4o7gB-4ewtA:
undetectable		 4o7gA-4ewtA:
20.25
4o7gB-4ewtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 6 PHE A  79
HIS A 134
ILE A  60
TYR A  44
 None
 1.43A 4o7gB-4ewtA:
undetectable		 4o7gB-4ewtA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		3 / 3 THR A 232
ASN A 302
PHE A 346
 None
 0.77A 4pd9A-4ewtA:
undetectable		 4pd9A-4ewtA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 9 VAL A 174
LEU A 115
LEU A 319
LEU A   9
ILE A   6
 None
 1.34A 4ubsA-4ewtA:
undetectable		 4ubsA-4ewtA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		3 / 3 GLU A  28
ILE A  60
ALA A 137
 None
 0.64A 4wnwB-4ewtA:
undetectable		 4wnwB-4ewtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 4 PHE A  31
ASP A  80
GLY A 143
SER A  30
 None
 1.36A 4xp9C-4ewtA:
undetectable		 4xp9C-4ewtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 4 PHE A  31
ASP A  80
GLY A 144
SER A  30
 None
 1.42A 4xp9C-4ewtA:
undetectable		 4xp9C-4ewtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 6 VAL A  51
LEU A 113
ILE A  40
ALA A  41
 None
 0.76A 4zf8A-4ewtA:
undetectable		 4zf8A-4ewtA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		3 / 3 THR A 263
ASP A 264
ALA A 265
 None
 0.08A 5g5gB-4ewtA:
undetectable		 5g5gB-4ewtA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		5 / 8 ASN A 367
PHE A 366
THR A 171
ILE A 368
GLY A 350
 None
 1.48A 5nzxA-4ewtA:
undetectable		 5nzxA-4ewtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 7 GLY A 197
SER A 200
GLY A 199
VAL A 248
 None
 0.77A 6ekzA-4ewtA:
undetectable		 6ekzA-4ewtA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4ewt PEPTIDASE,
M20/M25/M40 FAMILY
(Staphylococcus
aureus) 		4 / 6 VAL A 235
LEU A 219
LEU A 277
LEU A 190
 None
 1.07A 6f6sA-4ewtA:
undetectable
6f6sB-4ewtA:
0.0		 6f6sA-4ewtA:
11.14
6f6sB-4ewtA:
10.08