SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ex5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		5 / 12 PHE A 202
ALA A 427
GLY A 429
PHE A 417
LEU A 243
 None
None
LYS  A 601 ( 4.3A)
None
None
 1.20A 1qabF-4ex5A:
undetectable		 1qabF-4ex5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		3 / 3 THR A 179
PRO A 177
THR A 181
 None
 0.79A 209dC-4ex5A:
undetectable		 209dC-4ex5A:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		5 / 12 THR A 179
ARG A 186
TYR A 166
ASP A 172
LEU A 173
 None
 1.44A 2a5hB-4ex5A:
undetectable		 2a5hB-4ex5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		5 / 12 THR A 179
ARG A 186
TYR A 166
ASP A 172
LEU A 173
 None
 1.45A 2a5hC-4ex5A:
undetectable		 2a5hC-4ex5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		5 / 12 THR A 179
ARG A 186
TYR A 166
ASP A 172
LEU A 173
 None
 1.43A 2a5hD-4ex5A:
undetectable		 2a5hD-4ex5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 262
ASP A 454
ASP A 451
 LYS  A 601 (-3.7A)
None
None
 0.84A 2ejtA-4ex5A:
undetectable		 2ejtA-4ex5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		3 / 3 TYR A 109
VAL A  79
THR A 100
 None
 0.74A 2ygnA-4ex5A:
undetectable		 2ygnA-4ex5A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		4 / 5 ILE A 482
THR A 293
PHE A 292
PHE A 202
 None
 1.34A 3em0A-4ex5A:
undetectable		 3em0A-4ex5A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		4 / 7 ILE A 426
LEU A 488
ALA A 300
ALA A 301
 None
 0.74A 3r9tB-4ex5A:
undetectable		 3r9tB-4ex5A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		5 / 10 ALA A  69
ARG A 124
GLY A 125
LEU A  49
ILE A  95
 None
 1.06A 3wdmB-4ex5A:
undetectable		 3wdmB-4ex5A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_G_ZPCG1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		5 / 12 ARG A 484
ILE A 495
GLU A 456
GLU A 384
GLU A 418
 None
 1.39A 4a97F-4ex5A:
0.0
4a97G-4ex5A:
0.6		 4a97F-4ex5A:
20.08
4a97G-4ex5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		4 / 9 TYR A 280
PHE A 430
ILE A 480
MET A 276
 LYS  A 601 (-4.5A)
LYS  A 601 (-3.5A)
None
None
 1.28A 4jvlA-4ex5A:
undetectable		 4jvlA-4ex5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		5 / 12 ASN A 428
ALA A 218
GLU A 432
GLU A 240
LEU A 241
 LYS  A 601 (-3.1A)
None
LYS  A 601 (-2.7A)
LYS  A 601 (-2.8A)
None
 1.40A 4zjoA-4ex5A:
1.0		 4zjoA-4ex5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		4 / 5 ALA A 301
ALA A 308
ILE A 310
LEU A 317
 None
 0.78A 5jncD-4ex5A:
undetectable		 5jncD-4ex5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		8 / 10 ASN A 260
ARG A 262
GLU A 264
PHE A 274
GLU A 425
GLY A 481
ARG A 484
ILE A 495
 None
LYS  A 601 (-3.7A)
None
None
None
None
None
None
 0.67A 6bniA-4ex5A:
44.4		 6bniA-4ex5A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4ex5 LYSINE--TRNA LIGASE
(Burkholderia
thailandensis) 		8 / 10 ASN A 260
ARG A 262
GLU A 264
PHE A 274
GLU A 425
GLY A 481
ARG A 484
ILE A 495
 None
LYS  A 601 (-3.7A)
None
None
None
None
None
None
 0.60A 6bniB-4ex5A:
44.1		 6bniB-4ex5A:
10.59