SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ex6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 9 ASP A 209
PRO A 167
ALA A 160
ILE A  13
THR A 189
 None
 1.44A 1aj6A-4ex6A:
undetectable		 1aj6A-4ex6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 12 LEU A  20
LEU A  95
GLU A 101
GLY A 102
ALA A 217
 None
 1.11A 2br4A-4ex6A:
undetectable		 2br4A-4ex6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 12 LEU A  20
LEU A  95
GLU A 101
GLY A 102
ALA A 217
 None
 1.12A 2br4D-4ex6A:
2.2		 2br4D-4ex6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 12 ALA A 180
GLY A  18
ASP A 179
LEU A 203
SER A 198
 None
MG  A 301 ( 4.3A)
MG  A 301 ( 4.5A)
None
None
 1.32A 2nv4A-4ex6A:
undetectable		 2nv4A-4ex6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		6 / 12 GLY A 207
ALA A 208
ASP A 209
VAL A 212
ILE A 191
GLY A 174
 None
 1.48A 2q5kB-4ex6A:
undetectable		 2q5kB-4ex6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 9 ALA A 116
ASP A  15
VAL A 172
PRO A 167
ILE A  13
 None
MG  A 301 (-2.6A)
None
None
None
 1.00A 3ekvB-4ex6A:
undetectable		 3ekvB-4ex6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 10 ALA A 116
ASP A 179
VAL A 172
PRO A 167
ILE A  13
 None
MG  A 301 ( 4.5A)
None
None
None
 0.96A 3em3B-4ex6A:
undetectable		 3em3B-4ex6A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 12 THR A  29
ILE A  30
ALA A  26
ALA A  90
ALA A  85
 None
 0.97A 3mdvB-4ex6A:
undetectable		 3mdvB-4ex6A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 10 ALA A 116
ASP A  15
VAL A 172
PRO A 167
ILE A  13
 None
MG  A 301 (-2.6A)
None
None
None
 0.91A 3nu6A-4ex6A:
undetectable		 3nu6A-4ex6A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 11 VAL A  99
LEU A 100
TYR A 195
GLY A  18
ALA A  21
 None
None
None
MG  A 301 ( 4.3A)
None
 1.20A 3pghB-4ex6A:
undetectable		 3pghB-4ex6A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		4 / 8 ASP A 104
VAL A  12
PHE A 215
LEU A  20
 None
 0.98A 4f8hA-4ex6A:
undetectable
4f8hB-4ex6A:
undetectable		 4f8hA-4ex6A:
23.17
4f8hB-4ex6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		4 / 8 ASP A 104
VAL A  12
PHE A 215
LEU A  20
 None
 1.04A 4f8hB-4ex6A:
undetectable
4f8hC-4ex6A:
undetectable		 4f8hB-4ex6A:
23.17
4f8hC-4ex6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		4 / 8 ASP A 104
VAL A  12
PHE A 215
LEU A  20
 None
 0.99A 4f8hC-4ex6A:
undetectable
4f8hD-4ex6A:
undetectable		 4f8hC-4ex6A:
23.17
4f8hD-4ex6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		4 / 8 ASP A 104
VAL A  12
PHE A 215
LEU A  20
 None
 1.00A 4f8hD-4ex6A:
undetectable
4f8hE-4ex6A:
undetectable		 4f8hD-4ex6A:
23.17
4f8hE-4ex6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		4 / 8 VAL A  12
PHE A 215
LEU A  20
ASP A 104
 None
 1.03A 4f8hA-4ex6A:
undetectable
4f8hE-4ex6A:
undetectable		 4f8hA-4ex6A:
23.17
4f8hE-4ex6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 9 VAL A 190
VAL A 172
VAL A 212
GLY A 176
ALA A 206
 None
 1.24A 4fwdA-4ex6A:
2.7		 4fwdA-4ex6A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 12 TYR A  79
VAL A 197
LEU A  16
LEU A  55
LEU A  59
 None
 1.25A 4rtbA-4ex6A:
undetectable		 4rtbA-4ex6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		4 / 8 ALA A  32
THR A  31
TYR A  79
VAL A  51
 BO3  A 302 (-3.3A)
None
None
None
 0.87A 5ecnD-4ex6A:
undetectable		 5ecnD-4ex6A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		4 / 6 LEU A 106
VAL A  12
LEU A  14
VAL A 171
 None
 0.96A 5x7zA-4ex6A:
undetectable		 5x7zA-4ex6A:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 12 VAL A 197
PRO A  24
THR A  23
HIS A  86
THR A 131
 None
 1.26A 5xipA-4ex6A:
undetectable		 5xipA-4ex6A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ex6 ALNB
(Streptomyces
sp.
CM020) 		5 / 12 VAL A 197
PRO A  24
THR A  23
HIS A  86
THR A 131
 None
 1.23A 5xipC-4ex6A:
undetectable		 5xipC-4ex6A:
18.00