SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ex9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 10 LEU A   9
ILE A  87
GLY A 108
ILE A 110
VAL A  68
 None
 1.03A 1d4yA-4ex9A:
undetectable		 1d4yA-4ex9A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 LEU A  28
LEU A 286
ALA A 289
THR A 122
VAL A  26
 None
 1.19A 1ictA-4ex9A:
undetectable
1ictC-4ex9A:
undetectable		 1ictA-4ex9A:
19.75
1ictC-4ex9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 9 LEU A   9
ILE A  87
GLY A 108
ILE A 110
VAL A  68
 None
 0.93A 2avoA-4ex9A:
undetectable		 2avoA-4ex9A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 LEU A   9
ILE A  87
GLY A 108
ILE A 110
VAL A  68
 None
 1.03A 2o4pA-4ex9A:
undetectable		 2o4pA-4ex9A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		4 / 4 ALA A 113
VAL A  26
PHE A 121
THR A  58
 None
 1.45A 2pkkA-4ex9A:
undetectable		 2pkkA-4ex9A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		4 / 7 ILE A  75
LEU A  74
VAL A  67
GLY A  60
 None
 0.72A 2wd9A-4ex9A:
undetectable		 2wd9A-4ex9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		4 / 8 ILE A  75
LEU A  74
VAL A  67
GLY A  60
 None
 0.72A 2wd9B-4ex9A:
undetectable		 2wd9B-4ex9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		4 / 7 LEU A 224
ALA A 158
GLY A 127
PHE A 146
 None
None
5RP  A 402 ( 4.2A)
None
 0.93A 2wq5A-4ex9A:
undetectable		 2wq5A-4ex9A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 9 LEU A   9
ILE A  87
GLY A 108
ILE A 110
VAL A  68
 None
 1.07A 3d1yB-4ex9A:
undetectable		 3d1yB-4ex9A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 LEU A   9
ILE A  87
GLY A 108
ILE A 110
VAL A  68
 None
 0.91A 3mwsB-4ex9A:
undetectable		 3mwsB-4ex9A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 9 LEU A 286
ALA A 289
LEU A 285
THR A 122
VAL A  26
 None
 1.43A 3ozkA-4ex9A:
undetectable		 3ozkA-4ex9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 10 ILE A  33
SER A  43
ILE A  75
ALA A  79
GLU A  76
 None
 1.41A 3u6tA-4ex9A:
undetectable		 3u6tA-4ex9A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 SER A 300
LEU A 299
ILE A 118
VAL A 120
VAL A  49
 None
 1.19A 3w68A-4ex9A:
undetectable		 3w68A-4ex9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 ILE A 110
THR A 109
THR A 288
ASP A 142
ILE A 126
 None
None
None
5RP  A 402 (-3.0A)
None
 1.34A 4i41A-4ex9A:
undetectable		 4i41A-4ex9A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 ALA A 188
ARG A 165
LEU A 171
LEU A 143
ILE A 126
 None
 1.04A 4m2xE-4ex9A:
undetectable		 4m2xE-4ex9A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.25A 4qvlV-4ex9A:
undetectable
4qvlb-4ex9A:
undetectable		 4qvlV-4ex9A:
22.39
4qvlb-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.24A 4qvlH-4ex9A:
undetectable
4qvlN-4ex9A:
undetectable		 4qvlH-4ex9A:
22.39
4qvlN-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.24A 4qvmV-4ex9A:
undetectable
4qvmb-4ex9A:
undetectable		 4qvmV-4ex9A:
22.39
4qvmb-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.24A 4qvmH-4ex9A:
undetectable
4qvmN-4ex9A:
undetectable		 4qvmH-4ex9A:
22.39
4qvmN-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.26A 4qvwV-4ex9A:
undetectable
4qvwb-4ex9A:
undetectable		 4qvwV-4ex9A:
22.39
4qvwb-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.26A 4qvwH-4ex9A:
undetectable
4qvwN-4ex9A:
undetectable		 4qvwH-4ex9A:
22.39
4qvwN-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.25A 4qw0V-4ex9A:
undetectable
4qw0b-4ex9A:
undetectable		 4qw0V-4ex9A:
22.39
4qw0b-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.24A 4qw0H-4ex9A:
undetectable
4qw0N-4ex9A:
undetectable		 4qw0H-4ex9A:
22.39
4qw0N-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.24A 4qw3V-4ex9A:
undetectable
4qw3b-4ex9A:
undetectable		 4qw3V-4ex9A:
22.39
4qw3b-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.25A 4qw3H-4ex9A:
undetectable
4qw3N-4ex9A:
undetectable		 4qw3H-4ex9A:
22.39
4qw3N-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 10 LEU A  28
GLY A 293
VAL A  49
THR A 288
VAL A  26
 None
 1.29A 4yb6A-4ex9A:
undetectable
4yb6D-4ex9A:
undetectable		 4yb6A-4ex9A:
21.80
4yb6D-4ex9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.26A 5cz7H-4ex9A:
undetectable
5cz7N-4ex9A:
undetectable		 5cz7H-4ex9A:
22.39
5cz7N-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.24A 5d0xV-4ex9A:
undetectable
5d0xb-4ex9A:
undetectable		 5d0xV-4ex9A:
22.39
5d0xb-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.24A 5d0xH-4ex9A:
undetectable
5d0xN-4ex9A:
undetectable		 5d0xH-4ex9A:
22.39
5d0xN-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 9 LEU A   9
ILE A  87
GLY A 108
ILE A 110
VAL A  68
 None
 1.00A 5kr2D-4ex9A:
undetectable		 5kr2D-4ex9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.25A 5l5zV-4ex9A:
undetectable
5l5zb-4ex9A:
undetectable		 5l5zV-4ex9A:
22.39
5l5zb-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.25A 5l5zH-4ex9A:
undetectable
5l5zN-4ex9A:
undetectable		 5l5zH-4ex9A:
22.39
5l5zN-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.27A 5l66V-4ex9A:
undetectable
5l66b-4ex9A:
undetectable		 5l66V-4ex9A:
22.39
5l66b-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A  34
THR A  81
GLY A  60
ALA A 103
THR A 104
 None
 1.27A 5l66H-4ex9A:
undetectable
5l66N-4ex9A:
undetectable		 5l66H-4ex9A:
22.39
5l66N-4ex9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 ILE A  45
GLY A 293
ALA A 289
ALA A 298
ALA A  52
 None
 1.06A 5zw4A-4ex9A:
undetectable		 5zw4A-4ex9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 ALA A 194
ALA A 213
ALA A 211
THR A 152
LEU A 225
 None
 1.34A 6aycA-4ex9A:
undetectable		 6aycA-4ex9A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 SER A 155
LEU A  32
ALA A 292
PHE A 121
VAL A 106
 None
None
None
None
5RP  A 402 (-4.0A)
 1.36A 6dryA-4ex9A:
undetectable		 6dryA-4ex9A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 GLY A 128
GLY A 127
VAL A 106
VAL A 153
GLY A 157
 None
5RP  A 402 ( 4.2A)
5RP  A 402 (-4.0A)
None
None
 1.10A 6gneA-4ex9A:
2.3		 6gneA-4ex9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 12 GLY A 128
GLY A 127
VAL A 106
VAL A 153
GLY A 157
 None
5RP  A 402 ( 4.2A)
5RP  A 402 (-4.0A)
None
None
 1.10A 6gneB-4ex9A:
undetectable		 6gneB-4ex9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4ex9 ALNA
(Streptomyces
sp.
CM020) 		5 / 11 THR A 149
VAL A 153
MET A 151
THR A 105
ILE A  87
 None
None
None
5RP  A 402 (-3.9A)
None
 1.37A 6hcoA-4ex9A:
undetectable
6hcoB-4ex9A:
undetectable		 6hcoA-4ex9A:
20.09
6hcoB-4ex9A:
20.09