SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4exb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 266
LEU A 267
VAL A 212
ILE A 247
LEU A 216
 None
 1.02A 1fm6U-4exbA:
undetectable		 1fm6U-4exbA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  95
ILE A 129
ILE A 162
LEU A 156
ARG A 119
 None
 1.04A 1qhyA-4exbA:
undetectable		 1qhyA-4exbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 119
ARG A 123
ILE A 129
 None
 0.73A 1uobA-4exbA:
undetectable		 1uobA-4exbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 130
ARG A 128
ILE A  65
GLU A  87
ASP A 127
 None
 1.21A 2qeoA-4exbA:
undetectable		 2qeoA-4exbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 GLU A 130
ARG A 128
ILE A  65
GLU A  87
ASP A 127
 None
 1.25A 2qeoB-4exbA:
undetectable		 2qeoB-4exbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 GLU A 130
ILE A  91
ARG A 128
GLU A  87
ASP A 127
 None
 1.45A 2qeoB-4exbA:
undetectable		 2qeoB-4exbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  25
ALA A  55
LEU A  53
ALA A  50
PHE A  30
 None
 1.29A 2vcvH-4exbA:
undetectable		 2vcvH-4exbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 215
LEU A 191
SER A 218
VAL A 248
 None
 1.01A 3d2tB-4exbA:
undetectable		 3d2tB-4exbA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		6 / 12 ALA A 266
GLN A 265
LEU A 267
VAL A 212
ILE A 247
LEU A 216
 None
 1.45A 3oapA-4exbA:
undetectable		 3oapA-4exbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 MET A 186
LEU A 211
ALA A 246
LEU A  23
GLY A  26
 None
 0.96A 3olsA-4exbA:
undetectable		 3olsA-4exbA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 203
GLY A 175
VAL A 172
VAL A 212
ILE A 210
 None
 0.76A 3oxvA-4exbA:
undetectable		 3oxvA-4exbA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 203
GLY A 175
VAL A 172
VAL A 212
ILE A 210
 None
 0.90A 3oxwD-4exbA:
undetectable		 3oxwD-4exbA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 SER A  93
ASP A  66
ILE A 129
THR A  27
 None
 0.78A 4acbC-4exbA:
3.6		 4acbC-4exbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 256
ILE A 251
LEU A  25
LEU A  54
ALA A  57
 None
 0.81A 4p65B-4exbA:
undetectable
4p65D-4exbA:
undetectable
4p65I-4exbA:
undetectable
4p65J-4exbA:
undetectable		 4p65B-4exbA:
7.35
4p65D-4exbA:
7.35
4p65I-4exbA:
8.48
4p65J-4exbA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  47
ARG A  83
PRO A  80
 None
 0.93A 4wanC-4exbA:
undetectable		 4wanC-4exbA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 108
SER A 136
VAL A 134
ALA A 185
GLY A 169
 None
 1.33A 5tzoA-4exbA:
undetectable		 5tzoA-4exbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 108
SER A 136
VAL A 134
ALA A 185
GLY A 169
 None
 1.35A 5tzoC-4exbA:
undetectable		 5tzoC-4exbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 ARG A  86
GLU A  87
GLU A 130
ARG A 128
 None
 1.32A 6fk2A-4exbA:
undetectable		 6fk2A-4exbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4exb PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 128
GLU A 130
GLU A  87
ARG A  86
 None
 1.01A 6fk2A-4exbA:
undetectable		 6fk2A-4exbA:
20.00