SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4exk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
4 / 7 LEU A 304
ILE A 329
THR A  93
MET A 321
None
None
None
PGE  A 502 (-4.4A)
1.18A 1kglA-4exkA:
undetectable
1kglA-4exkA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 11 VAL A 407
ALA A 369
ILE A 178
ALA A 338
ASP A 177
None
1.26A 2admB-4exkA:
undetectable
2admB-4exkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 12 LEU A 262
ILE A 108
VAL A  97
LEU A  76
ILE A  79
None
1.09A 2h42C-4exkA:
undetectable
2h42C-4exkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 12 LEU A 192
THR A 193
ALA A 346
THR A 345
ILE A 348
None
1.22A 3a35A-4exkA:
undetectable
3a35A-4exkA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
None
0.96A 3bgdA-4exkA:
undetectable
3bgdA-4exkA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
None
0.70A 3bjwC-4exkA:
undetectable
3bjwC-4exkA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
None
1.32A 3gv1A-4exkA:
undetectable
3gv1C-4exkA:
undetectable
3gv1A-4exkA:
13.14
3gv1C-4exkA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
None
1.30A 3gv1A-4exkA:
undetectable
3gv1B-4exkA:
undetectable
3gv1A-4exkA:
13.14
3gv1B-4exkA:
13.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
12 / 12 ASP A  14
LYS A  15
LYS A  42
GLU A  44
GLU A  45
ALA A  63
ASP A  65
ARG A  66
GLU A 111
PRO A 154
TRP A 230
TYR A 341
MTT  A 501 (-2.9A)
MTT  A 501 (-2.8A)
MTT  A 501 (-4.1A)
MTT  A 501 (-3.1A)
MTT  A 501 (-3.6A)
MTT  A 501 (-3.3A)
MTT  A 501 (-2.8A)
MTT  A 501 (-3.8A)
MTT  A 501 (-2.8A)
MTT  A 501 (-3.4A)
MTT  A 501 (-4.3A)
MTT  A 501 (-4.6A)
0.23A 3jyrA-4exkA:
62.4
3jyrA-4exkA:
72.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
7 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
ARG A 344
MTT  A 501 ( 4.7A)
MTT  A 501 (-4.2A)
MTT  A 501 (-3.3A)
MTT  A 501 (-3.7A)
MTT  A 501 ( 4.4A)
MTT  A 501 (-3.9A)
MTT  A 501 (-3.9A)
0.15A 3jyrA-4exkA:
62.4
3jyrA-4exkA:
72.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 11 GLN A 365
ALA A 364
ALA A 162
GLY A 166
ALA A 188
None
1.10A 3mg0V-4exkA:
undetectable
3mg0W-4exkA:
undetectable
3mg0V-4exkA:
21.02
3mg0W-4exkA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
None
1.00A 3n8yB-4exkA:
undetectable
3n8yB-4exkA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 9 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
None
1.26A 3sj4X-4exkA:
undetectable
3sj4X-4exkA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
None
None
None
MTT  A 501 (-2.8A)
None
0.86A 3tbgB-4exkA:
undetectable
3tbgB-4exkA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
None
None
None
MTT  A 501 (-2.8A)
None
0.84A 3tbgD-4exkA:
undetectable
3tbgD-4exkA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 12 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
None
1.31A 3vwqA-4exkA:
undetectable
3vwqA-4exkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
None
1.36A 3vywD-4exkA:
undetectable
3vywD-4exkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 12 ILE A 402
THR A 378
VAL A 407
ASP A 401
VAL A 399
None
1.06A 4c9lA-4exkA:
undetectable
4c9lA-4exkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
None
1.16A 4or0B-4exkA:
undetectable
4or0B-4exkA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
4 / 6 LEU A 304
ILE A 329
THR A  93
MET A 321
None
None
None
PGE  A 502 (-4.4A)
1.25A 5ljeA-4exkA:
undetectable
5ljeA-4exkA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
3 / 3 LYS A 422
TRP A 425
SER A 449
None
1.32A 5nwwA-4exkA:
undetectable
5nwwA-4exkA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
None
1.48A 5w4zA-4exkA:
undetectable
5w4zA-4exkA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
3 / 3 TYR A 155
ASN A 227
LEU A 113
MTT  A 501 (-3.7A)
None
None
0.81A 6b58A-4exkA:
undetectable
6b58A-4exkA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
None
1.34A 6bm5A-4exkA:
undetectable
6bm5A-4exkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 12 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
None
1.00A 6ecxA-4exkA:
undetectable
6ecxA-4exkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 12 GLN A 365
ALA A 364
ALA A 162
GLY A 166
ALA A 188
None
1.02A 6hwdH-4exkA:
undetectable
6hwdI-4exkA:
undetectable
6hwdH-4exkA:
15.41
6hwdI-4exkA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica)
5 / 11 GLN A 365
ALA A 364
ALA A 162
GLY A 166
ALA A 188
None
1.02A 6hwdV-4exkA:
undetectable
6hwdV-4exkA:
15.41