SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4exl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		6 / 11 GLY A 195
ALA A 196
VAL A 186
ILE A 113
ILE A 131
ILE A 152
 None
 1.31A 1sdvB-4exlA:
undetectable		 1sdvB-4exlA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		3 / 3 LEU A  44
LEU A  41
SER A  38
 None
 0.34A 1tlmA-4exlA:
undetectable		 1tlmA-4exlA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		4 / 6 LEU A  44
LEU A  41
SER A  38
SER A  68
 None
 0.96A 1tz8C-4exlA:
undetectable
1tz8D-4exlA:
undetectable		 1tz8C-4exlA:
19.18
1tz8D-4exlA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 12 LEU A 110
ILE A 197
ILE A 131
ILE A 168
TYR A 199
 None
 1.21A 2efjA-4exlA:
undetectable		 2efjA-4exlA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 11 ASN A  84
VAL A  36
ALA A  79
SER A  77
ASP A 102
 None
 1.49A 2iyfA-4exlA:
undetectable		 2iyfA-4exlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 12 THR A 259
VAL A 254
GLN A 260
LEU A 255
ILE A 272
 None
 1.50A 2xrlA-4exlA:
undetectable		 2xrlA-4exlA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 12 SER A  68
LEU A 110
HIS A 236
LEU A  72
TYR A 238
 None
 1.48A 3adsA-4exlA:
undetectable		 3adsA-4exlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 12 SER A  68
LEU A 110
HIS A 236
LEU A  72
TYR A 238
 None
 1.49A 3adxA-4exlA:
undetectable		 3adxA-4exlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 6 GLY A  65
GLY A  37
GLY A  71
GLY A  66
GLY A  69
 None
 1.01A 3bogA-4exlA:
undetectable
3bogC-4exlA:
undetectable		 3bogA-4exlA:
undetectable
3bogC-4exlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		3 / 3 THR A 166
GLU A  91
HIS A 236
 None
 0.68A 3g1uB-4exlA:
undetectable		 3g1uB-4exlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		4 / 8 VAL A 285
VAL A 277
LYS A 279
ILE A 224
 None
None
CL  A 305 ( 4.3A)
None
 0.73A 3warA-4exlA:
undetectable		 3warA-4exlA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 10 ASP A  86
GLY A  69
SER A  38
GLY A  65
ASP A 181
 None
 1.45A 4mmcA-4exlA:
undetectable		 4mmcA-4exlA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		4 / 6 ASP A 102
VAL A 105
SER A  38
ALA A  89
 None
 0.98A 4nedA-4exlA:
8.1		 4nedA-4exlA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 11 ASP A  86
ALA A  35
GLY A  66
SER A  85
GLY A  83
 None
 1.18A 4xnxA-4exlA:
undetectable		 4xnxA-4exlA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 11 ASN A 153
SER A 160
GLY A 159
ASP A 165
GLU A 179
 None
 1.14A 4xt7A-4exlA:
undetectable		 4xt7A-4exlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 12 ASN A 153
SER A 160
GLY A 159
ALA A 162
GLU A 179
 None
 1.23A 4xt8A-4exlA:
undetectable		 4xt8A-4exlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 12 ASN A 153
SER A 160
GLY A 159
ASP A 165
GLU A 179
 None
 1.16A 4xt8A-4exlA:
undetectable		 4xt8A-4exlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 10 ASP A  86
ALA A  35
GLY A  66
SER A  85
GLY A  83
 None
 1.25A 5i6xA-4exlA:
undetectable		 5i6xA-4exlA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		4 / 8 THR A 203
SER A 233
ALA A  40
SER A  38
 None
CL  A 305 (-4.9A)
None
None
 1.08A 5l5fY-4exlA:
undetectable
5l5fZ-4exlA:
undetectable		 5l5fY-4exlA:
23.44
5l5fZ-4exlA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 9 ASP A  86
ALA A  35
GLY A  66
SER A  85
GLY A  83
 None
 1.31A 6awoA-4exlA:
undetectable		 6awoA-4exlA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4exl PHOSPHATE-BINDING
PROTEIN PSTS 1
(Streptococcus
pneumoniae) 		5 / 9 ASP A  86
ALA A  35
GLY A  66
SER A  85
GLY A  83
 None
 1.31A 6awqA-4exlA:
undetectable		 6awqA-4exlA:
17.31