SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4exp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4exp MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Mus
musculus) 		5 / 12 LEU X 248
ARG X 261
ALA X 226
PHE X 233
SER X 281
 None
 1.28A 3apwB-4expX:
undetectable		 3apwB-4expX:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4exp MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Mus
musculus) 		4 / 7 VAL X 101
LEU X  99
TYR X  82
LEU X 111
 None
 1.00A 3qeoB-4expX:
undetectable		 3qeoB-4expX:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4exp MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Mus
musculus) 		4 / 8 THR X  96
TRP X 159
HIS X  98
PRO X  53
 None
 1.02A 5v4vA-4expX:
undetectable		 5v4vA-4expX:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4exp MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Mus
musculus) 		4 / 8 THR X  96
TRP X 159
HIS X  98
PRO X  53
 None
 1.02A 5v4vB-4expX:
undetectable		 5v4vB-4expX:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4exp MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Mus
musculus) 		5 / 10 VAL X 195
ALA X 167
SER X 172
LEU X 193
ASN X 173
 None
 1.10A 5x6yB-4expX:
undetectable		 5x6yB-4expX:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4exp MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Mus
musculus) 		3 / 3 ARG X 261
LYS X 259
ARG X 197
 None
 1.21A 6c06D-4expX:
undetectable		 6c06D-4expX:
undetectable