SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4exq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 5 GLY A 152
LEU A 157
THR A 156
VAL A 195
 None
 1.00A 1ekjF-4exqA:
undetectable
1ekjG-4exqA:
undetectable		 1ekjF-4exqA:
22.93
1ekjG-4exqA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 6 LEU A  14
ASP A 271
GLY A 269
ARG A 242
 None
 0.89A 1mt1G-4exqA:
undetectable
1mt1J-4exqA:
undetectable		 1mt1G-4exqA:
10.71
1mt1J-4exqA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 7 ARG A 242
LEU A  14
ASP A 271
GLY A 269
 None
 0.90A 1mt1H-4exqA:
undetectable
1mt1K-4exqA:
undetectable		 1mt1H-4exqA:
15.20
1mt1K-4exqA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 6 ARG A 242
LEU A  14
ASP A 271
GLY A 269
 None
 0.92A 1n13H-4exqA:
undetectable
1n13K-4exqA:
undetectable		 1n13H-4exqA:
15.20
1n13K-4exqA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 7 LEU A  14
ASP A 271
GLY A 269
ARG A 242
 None
 0.91A 1n13G-4exqA:
undetectable
1n13J-4exqA:
undetectable		 1n13G-4exqA:
10.71
1n13J-4exqA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		5 / 12 PHE A 100
THR A 172
VAL A 173
LEU A 188
ILE A 187
 None
 0.87A 2fj1A-4exqA:
undetectable		 2fj1A-4exqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 6 THR A 255
ASP A 276
THR A 278
ASP A 299
 None
 1.17A 2okcB-4exqA:
undetectable		 2okcB-4exqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 8 ARG A 242
LEU A  14
ASP A 271
GLY A 269
 None
 0.86A 2qqdB-4exqA:
undetectable
2qqdC-4exqA:
undetectable		 2qqdB-4exqA:
15.20
2qqdC-4exqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 7 VAL A 249
ILE A 252
GLY A 274
LEU A 262
 None
 0.89A 3bjwB-4exqA:
undetectable		 3bjwB-4exqA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 7 VAL A 249
ILE A 252
GLY A 274
LEU A 262
 None
 0.92A 3bjwF-4exqA:
undetectable		 3bjwF-4exqA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 7 ASP A 214
GLY A 274
SER A 153
THR A 156
 None
 0.64A 4ac9C-4exqA:
2.7		 4ac9C-4exqA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		5 / 9 GLN A 143
VAL A 145
LEU A  65
LEU A  70
ILE A 148
 None
 1.45A 4c66A-4exqA:
undetectable		 4c66A-4exqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		3 / 3 TYR A  21
HIS A 352
ARG A 356
 NA  A 401 ( 4.8A)
None
None
 0.77A 4e7bC-4exqA:
0.2		 4e7bC-4exqA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 298
ASN A 297
GLY A 332
MET A  27
LEU A  26
 None
 1.15A 4p6xE-4exqA:
undetectable		 4p6xE-4exqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		5 / 11 LEU A  26
LEU A 331
GLU A 346
LEU A 347
LEU A 303
 None
 1.07A 4wg0J-4exqA:
undetectable
4wg0K-4exqA:
undetectable
4wg0L-4exqA:
undetectable		 4wg0J-4exqA:
9.65
4wg0K-4exqA:
9.65
4wg0L-4exqA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		6 / 12 LEU A 262
GLY A 296
GLY A 332
PRO A 300
LEU A 298
LEU A 281
 None
 1.34A 4x61A-4exqA:
3.4		 4x61A-4exqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 7 ASP A 214
PHE A 254
GLY A 258
GLY A 218
 None
 1.05A 5n9xA-4exqA:
undetectable		 5n9xA-4exqA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 144
PHE A  10
LEU A  65
 None
 0.75A 5x1bC-4exqA:
undetectable		 5x1bC-4exqA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 7 PHE A  92
LEU A  90
ILE A 118
ALA A  51
 None
 0.80A 6b5vA-4exqA:
undetectable
6b5vC-4exqA:
undetectable		 6b5vA-4exqA:
15.03
6b5vC-4exqA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 7 PHE A  92
LEU A  90
ILE A 118
ALA A  51
 None
 0.81A 6b5vC-4exqA:
undetectable
6b5vD-4exqA:
undetectable		 6b5vC-4exqA:
15.03
6b5vD-4exqA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4exq UROPORPHYRINOGEN
DECARBOXYLASE
(Burkholderia
thailandensis) 		4 / 7 ALA A  51
PHE A  92
LEU A  90
ILE A 118
 None
 0.80A 6b5vB-4exqA:
undetectable
6b5vD-4exqA:
undetectable		 6b5vB-4exqA:
15.03
6b5vD-4exqA:
15.03