SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4exr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
5 / 9 LEU A  84
ILE A  81
GLY A  99
SER A 166
LEU A 167
None
1.03A 3ai9X-4exrA:
undetectable
3ai9X-4exrA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
3 / 3 GLU A 137
ASP A  83
ASP A 170
None
NA  A 301 (-2.6A)
None
0.53A 3jb2A-4exrA:
undetectable
3jb2A-4exrA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.36A 4ctjC-4exrA:
undetectable
4ctjC-4exrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.27A 5ec8C-4exrA:
undetectable
5ec8C-4exrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.27A 5ekxB-4exrA:
undetectable
5ekxB-4exrA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.24A 5wz1A-4exrA:
undetectable
5wz1A-4exrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.21A 5wz1C-4exrA:
undetectable
5wz1C-4exrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.23A 5wz1D-4exrA:
undetectable
5wz1D-4exrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.21A 5wz1E-4exrA:
undetectable
5wz1E-4exrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.21A 5wz1F-4exrA:
undetectable
5wz1F-4exrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.21A 5wz1G-4exrA:
undetectable
5wz1G-4exrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
6 / 12 GLY A 132
GLY A  99
GLU A 137
VAL A  97
ASP A  80
ILE A  81
None
1.18A 5wz1H-4exrA:
undetectable
5wz1H-4exrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)
4exr PUTATIVE LIPOPROTEIN
(Clostridioides
difficile)
5 / 9 ILE A 178
ILE A 189
GLU A  87
VAL A 162
ILE A 180
None
1.39A 6hloA-4exrA:
undetectable
6hloA-4exrA:
15.62