SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		3 / 3 MET A 288
VAL A 182
GLU A 115
 None
 0.82A 3c6gA-4eyeA:
undetectable		 3c6gA-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		5 / 12 THR A 225
ALA A 147
ALA A 218
ILE A 186
THR A 176
 None
 1.14A 3czhA-4eyeA:
undetectable		 3czhA-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		5 / 12 THR A 225
ALA A 147
ALA A 218
ILE A 186
THR A 176
 None
 1.12A 3czhB-4eyeA:
undetectable		 3czhB-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		5 / 12 THR A 225
ALA A 147
ALA A 218
ILE A 186
THR A 176
 None
 1.13A 3dl9B-4eyeA:
undetectable		 3dl9B-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		5 / 12 THR A 225
VAL A 170
ALA A 147
ALA A 218
THR A 176
 None
IOD  A 403 ( 4.4A)
None
None
None
 1.21A 3dl9B-4eyeA:
undetectable		 3dl9B-4eyeA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		3 / 3 GLU A  64
VAL A  39
CYH A  40
 None
 1.04A 3fbxA-4eyeA:
0.4		 3fbxA-4eyeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A  92
GLY A  91
ALA A   3
ILE A  63
PRO A 321
 None
None
None
MPD  A 401 (-4.3A)
None
 1.09A 3jayA-4eyeA:
undetectable		 3jayA-4eyeA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		5 / 12 ILE A  90
GLY A  91
GLY A  92
ALA A   3
ALA A  98
 None
 0.88A 3jb2A-4eyeA:
4.7		 3jb2A-4eyeA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		5 / 9 GLY A 183
ALA A 184
ASP A 185
ILE A 167
ILE A 158
 None
 1.03A 3ogpB-4eyeA:
undetectable		 3ogpB-4eyeA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		5 / 11 VAL A 144
LEU A 143
VAL A 179
GLY A 183
ALA A 184
 None
 1.13A 3pghB-4eyeA:
undetectable		 3pghB-4eyeA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		3 / 3 TYR A  44
GLY A  11
PRO A  12
 None
 0.54A 4qwpA-4eyeA:
undetectable		 4qwpA-4eyeA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		4 / 6 PHE A 178
GLY A 315
GLN A 157
TYR A 123
 None
 0.85A 6ag0A-4eyeA:
undetectable		 6ag0A-4eyeA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		4 / 6 PHE A 178
GLY A 315
THR A 153
GLN A 157
 None
 0.83A 6ag0A-4eyeA:
undetectable		 6ag0A-4eyeA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		4 / 6 PHE A 178
GLY A 315
GLN A 157
TYR A 123
 None
 0.79A 6ag0C-4eyeA:
undetectable		 6ag0C-4eyeA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4eye PROBABLE
OXIDOREDUCTASE
(Mycobacteroides
abscessus) 		4 / 6 PHE A 178
GLY A 315
THR A 153
GLN A 157
 None
 0.82A 6ag0C-4eyeA:
undetectable		 6ag0C-4eyeA:
12.28