SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 309
LEU A  56
ALA A  53
TYR A 310
 None
None
None
EDO  A 402 (-4.5A)
 0.81A 1dmaA-4eygA:
undetectable		 1dmaA-4eygA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 8 GLY A 312
HIS A 314
THR A 143
ILE A 124
 None
EDO  A 402 (-3.8A)
None
None
 0.72A 1gtnE-4eygA:
undetectable
1gtnF-4eygA:
undetectable		 1gtnE-4eygA:
12.23
1gtnF-4eygA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 312
HIS A 314
THR A 143
ILE A 124
 None
EDO  A 402 (-3.8A)
None
None
 0.65A 1gtnF-4eygA:
undetectable
1gtnG-4eygA:
undetectable		 1gtnF-4eygA:
12.23
1gtnG-4eygA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 312
HIS A 314
THR A 143
ILE A 124
 None
EDO  A 402 (-3.8A)
None
None
 0.76A 1gtnJ-4eygA:
undetectable
1gtnK-4eygA:
undetectable		 1gtnJ-4eygA:
12.23
1gtnK-4eygA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		3 / 3 ASP A 258
PHE A 225
ASN A 233
 None
VNL  A 401 ( 4.8A)
None
 0.87A 1sg9B-4eygA:
3.4		 1sg9B-4eygA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		5 / 12 GLY A  42
GLY A  41
ASP A 259
GLY A 303
ARG A 301
 None
 1.01A 1sqfA-4eygA:
undetectable		 1sqfA-4eygA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 8 ASN A 360
LYS A 380
GLU A 342
GLY A 346
 None
 1.08A 1ykiA-4eygA:
undetectable
1ykiB-4eygA:
undetectable		 1ykiA-4eygA:
21.93
1ykiB-4eygA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 8 ASN A 360
LYS A 380
GLU A 342
GLY A 346
 None
 1.09A 1ykiC-4eygA:
undetectable
1ykiD-4eygA:
undetectable		 1ykiC-4eygA:
21.93
1ykiD-4eygA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		6 / 12 ALA A  53
GLY A 312
GLY A 309
VAL A 316
VAL A 125
GLY A 102
 None
 1.29A 2qe6A-4eygA:
undetectable		 2qe6A-4eygA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 6 GLY A 104
GLY A 229
PHE A 304
PHE A 145
 None
None
VNL  A 401 (-4.7A)
VNL  A 401 (-4.7A)
 1.01A 2qx6A-4eygA:
4.0
2qx6B-4eygA:
undetectable		 2qx6A-4eygA:
23.08
2qx6B-4eygA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		3 / 3 LEU A 315
MET A 339
MET A 277
 None
 1.02A 2vavF-4eygA:
undetectable		 2vavF-4eygA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		5 / 12 ILE A 313
GLY A 312
GLY A 102
LEU A  35
ILE A  50
 None
 1.03A 2y7kD-4eygA:
undetectable		 2y7kD-4eygA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		5 / 12 VAL A  72
GLY A 309
TYR A  57
SER A 144
ARG A 142
 None
 1.22A 2zthA-4eygA:
4.4		 2zthA-4eygA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 255
LEU A 147
GLY A 129
HIS A 276
 VNL  A 401 (-3.5A)
None
VNL  A 401 (-3.7A)
None
 1.03A 3af0A-4eygA:
undetectable		 3af0A-4eygA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 5 PRO A 253
THR A 390
GLY A 388
LYS A 389
 None
 1.12A 3elzA-4eygA:
undetectable		 3elzA-4eygA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		3 / 3 ASP A 259
ASN A 263
SER A 279
 None
 0.99A 3lsfB-4eygA:
undetectable
3lsfE-4eygA:
undetectable		 3lsfB-4eygA:
23.02
3lsfE-4eygA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		5 / 12 ILE A 133
VAL A 125
GLY A 104
THR A 130
PRO A 175
 None
None
None
None
VNL  A 401 (-4.0A)
 0.87A 3s56A-4eygA:
undetectable		 3s56A-4eygA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 5 HIS A 276
TYR A 362
TYR A 278
GLU A 377
 None
 1.37A 4ae1B-4eygA:
undetectable		 4ae1B-4eygA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		5 / 12 GLN A 237
ALA A 208
GLN A 212
ILE A 198
GLU A 196
 None
 1.19A 4azwA-4eygA:
undetectable		 4azwA-4eygA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		3 / 3 LYS A  68
LEU A 320
ALA A  66
 None
 0.85A 4iizA-4eygA:
undetectable		 4iizA-4eygA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		4 / 7 GLY A 229
THR A  46
VAL A 226
HIS A 276
 None
VNL  A 401 (-3.9A)
None
None
 0.96A 4qwpB-4eygA:
undetectable		 4qwpB-4eygA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		6 / 11 ALA A 158
VAL A 273
ILE A 363
ILE A 152
PRO A 253
ILE A 251
 None
 1.41A 4rvjA-4eygA:
undetectable		 4rvjA-4eygA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		6 / 11 ALA A 158
VAL A 273
ILE A 363
ILE A 152
PRO A 253
ILE A 251
 None
 1.42A 4rvjC-4eygA:
undetectable		 4rvjC-4eygA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		5 / 9 ALA A 179
PHE A 183
VAL A 256
SER A 171
VAL A 226
 None
 1.32A 4z69A-4eygA:
undetectable		 4z69A-4eygA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodopseudomonas
palustris) 		5 / 12 GLU A 123
VAL A 125
LEU A 202
SER A 144
GLY A  47
 None
 0.95A 5syeB-4eygA:
5.4		 5syeB-4eygA:
21.62