SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 228
ALA A 226
ALA A 248
THR A 245
VAL A 219
 None
 1.24A 1cbrA-4eyoA:
undetectable		 1cbrA-4eyoA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 228
ALA A 226
ALA A 248
THR A 245
VAL A 219
 None
 1.24A 1cbrB-4eyoA:
undetectable		 1cbrB-4eyoA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 10 LEU A 122
ALA A 351
VAL A  37
LEU A  54
GLN A 140
 None
 1.32A 1rlbE-4eyoA:
undetectable		 1rlbE-4eyoA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 4 PHE A 314
ASP A 312
PHE A 311
VAL A  57
 None
 1.49A 1w0fA-4eyoA:
undetectable		 1w0fA-4eyoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 GLY A 247
THR A 224
ALA A 225
ALA A 226
 HC4  A 401 (-3.4A)
None
None
None
 0.58A 2ej3A-4eyoA:
undetectable		 2ej3A-4eyoA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 11 GLU A 289
LEU A 288
ARG A 303
TYR A 294
PHE A  56
 None
 1.47A 2h21B-4eyoA:
undetectable		 2h21B-4eyoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 GLU A 360
TRP A 134
PRO A 118
ARG A 340
 None
 1.30A 2hs1B-4eyoA:
undetectable		 2hs1B-4eyoA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 11 VAL A 148
LEU A 149
GLY A 146
ILE A 142
PRO A 139
 None
None
None
None
HC4  A 401 (-4.0A)
 1.35A 3bjwE-4eyoA:
undetectable		 3bjwE-4eyoA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 9 ALA A  45
PHE A 306
VAL A 264
TYR A 381
ILE A 254
 None
 1.41A 3claA-4eyoA:
undetectable		 3claA-4eyoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 ILE A 254
VAL A 376
VAL A 264
GLN A 244
 None
 0.74A 3fi0G-4eyoA:
2.0		 3fi0G-4eyoA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 4 LEU A 178
GLY A 182
LEU A 187
GLU A 183
 None
 1.09A 3tgvB-4eyoA:
undetectable		 3tgvB-4eyoA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 PRO A 141
MET A 138
GLY A 269
PRO A 270
 None
 1.17A 3ucbB-4eyoA:
undetectable		 3ucbB-4eyoA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 PHE A 311
ASN A  52
GLY A 308
ALA A  58
GLU A  60
 None
 1.31A 3v3oB-4eyoA:
undetectable		 3v3oB-4eyoA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 PRO A 229
LEU A 233
ILE A 164
TYR A 163
TYR A 150
 None
 1.38A 4a79A-4eyoA:
undetectable		 4a79A-4eyoA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 PRO A 229
LEU A 233
ILE A 164
TYR A 163
TYR A 150
 None
 1.34A 4a79B-4eyoA:
undetectable		 4a79B-4eyoA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 11 ALA A  45
PHE A 306
VAL A 264
TYR A 381
ILE A 254
 None
 1.40A 4claA-4eyoA:
undetectable		 4claA-4eyoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 5 LEU A 317
ILE A  35
ALA A 313
MET A  68
 None
 1.02A 4dc3B-4eyoA:
undetectable		 4dc3B-4eyoA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 THR A  36
THR A  38
THR A  39
THR A  40
ALA A  44
 None
 1.24A 4qvnV-4eyoA:
undetectable
4qvnb-4eyoA:
undetectable		 4qvnV-4eyoA:
20.75
4qvnb-4eyoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 THR A  36
THR A  38
THR A  39
THR A  40
ALA A  44
 None
 1.23A 4qvnH-4eyoA:
undetectable
4qvnN-4eyoA:
undetectable		 4qvnH-4eyoA:
20.75
4qvnN-4eyoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 6 ALA A 225
SER A 222
SER A 167
ASP A 199
 None
HC4  A 401 (-2.4A)
None
None
 0.98A 5c6pA-4eyoA:
undetectable		 5c6pA-4eyoA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 249
GLY A 223
SER A 222
GLY A 269
HIS A 309
 None
None
HC4  A 401 (-2.4A)
None
HC4  A 401 (-3.8A)
 1.03A 5gwxA-4eyoA:
4.4		 5gwxA-4eyoA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 10 ILE A 189
ALA A 191
ALA A 216
ILE A 217
ILE A 158
 None
 1.00A 5mvmD-4eyoA:
undetectable
5mvmE-4eyoA:
undetectable		 5mvmD-4eyoA:
15.38
5mvmE-4eyoA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 161
ASP A 215
LEU A 373
LEU A 149
THR A 375
 None
 1.20A 5nd3B-4eyoA:
undetectable		 5nd3B-4eyoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 4 ARG A 194
PHE A 175
ASP A 177
LEU A 125
 None
 1.22A 5uhdC-4eyoA:
0.0		 5uhdC-4eyoA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		6 / 12 GLY A 220
GLY A 171
ILE A 142
ILE A 164
LEU A 218
LEU A 149
 None
 1.42A 5wy0A-4eyoA:
2.2		 5wy0A-4eyoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 PRO A 103
THR A 102
ARG A 197
THR A 245
GLY A 247
 None
HC4  A 401 (-3.7A)
HC4  A 401 (-2.9A)
None
HC4  A 401 (-3.4A)
 1.08A 5xipA-4eyoA:
3.6		 5xipA-4eyoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 161
LEU A 373
LEU A 149
THR A 375
GLY A 240
 None
 1.17A 6b0lB-4eyoA:
undetectable		 6b0lB-4eyoA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 6 ASN A 110
VAL A 106
VAL A 127
THR A 128
 None
 1.27A 6f32B-4eyoA:
undetectable		 6f32B-4eyoA:
22.41