SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 PHE A 192
VAL A 308
ILE A 245
TYR A 341
LEU A 311
 None
 1.24A 1fm4A-4eysA:
undetectable		 1fm4A-4eysA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 MET A  73
ILE A   5
THR A  83
THR A 111
LEU A 118
 None
 1.16A 1kqwA-4eysA:
undetectable		 1kqwA-4eysA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 PHE A 192
TYR A 145
PRO A 164
 None
 1.03A 1mcnA-4eysA:
undetectable
1mcnB-4eysA:
undetectable
1mcnP-4eysA:
undetectable		 1mcnA-4eysA:
19.42
1mcnB-4eysA:
19.42
1mcnP-4eysA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ASP A 286
THR A 317
GLU A 137
 None
 0.84A 1pj7A-4eysA:
undetectable		 1pj7A-4eysA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 PRO A 236
LEU A 206
GLY A 325
LYS A 244
 None
 1.46A 1ya4C-4eysA:
1.9		 1ya4C-4eysA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 LEU A 279
GLY A 278
LEU A 246
ILE A 272
ILE A 301
 None
 1.08A 2f8dA-4eysA:
1.7		 2f8dA-4eysA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 LEU A 279
GLY A 278
LEU A 246
ILE A 272
ILE A 301
 None
 1.05A 2f8dB-4eysA:
undetectable		 2f8dB-4eysA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 GLU A 211
GLY A 208
THR A 112
THR A 250
GLY A 314
 None
 1.34A 2fn1B-4eysA:
undetectable		 2fn1B-4eysA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A  36
VAL A  99
ILE A  74
MET A   1
 None
 1.17A 2hyyC-4eysA:
undetectable		 2hyyC-4eysA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ASP A 218
ASP A 269
ASP A 259
 None
 0.62A 2igtA-4eysA:
undetectable		 2igtA-4eysA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ASP A 218
ASP A 269
ASP A 259
 None
 0.63A 2igtB-4eysA:
undetectable		 2igtB-4eysA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 GLY A 325
ILE A 245
VAL A 322
PRO A 323
ILE A 162
 None
 1.27A 2nnhB-4eysA:
undetectable		 2nnhB-4eysA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 267
ASP A 240
GLY A 243
ILE A 245
ILE A 272
 None
 0.88A 2o4kA-4eysA:
undetectable		 2o4kA-4eysA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A 105
ILE A  14
THR A  83
GLY A 107
 None
 0.50A 2v0mB-4eysA:
undetectable		 2v0mB-4eysA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 LEU A  87
LEU A  62
LEU A 118
PHE A  91
THR A  83
 None
 1.14A 2w9hA-4eysA:
undetectable		 2w9hA-4eysA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 212
GLU A 252
ASP A 110
 ACT  A 402 (-3.2A)
AMP  A 401 (-3.1A)
ACT  A 402 (-4.9A)
 0.85A 2zthA-4eysA:
undetectable		 2zthA-4eysA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 146
GLU A 171
ASP A 174
 None
AMP  A 401 (-3.5A)
None
 0.77A 2zulA-4eysA:
undetectable		 2zulA-4eysA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 212
GLU A 252
ASP A 110
 ACT  A 402 (-3.2A)
AMP  A 401 (-3.1A)
ACT  A 402 (-4.9A)
 0.87A 3bwmA-4eysA:
undetectable		 3bwmA-4eysA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 146
GLU A 171
ASP A 174
 None
AMP  A 401 (-3.5A)
None
 0.73A 3dmhA-4eysA:
2.2		 3dmhA-4eysA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 GLY A  79
GLY A  80
SER A 109
HIS A 315
 AMP  A 401 (-3.0A)
AMP  A 401 (-4.7A)
AMP  A 401 (-2.9A)
AMP  A 401 (-3.9A)
 0.65A 3o9mA-4eysA:
2.0		 3o9mA-4eysA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLY A  79
GLY A  80
SER A 109
HIS A 315
 AMP  A 401 (-3.0A)
AMP  A 401 (-4.7A)
AMP  A 401 (-2.9A)
AMP  A 401 (-3.9A)
 0.71A 3o9mB-4eysA:
2.0		 3o9mB-4eysA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 SER A 176
THR A 178
GLU A  23
ASP A 134
 None
None
AMP  A 401 (-2.9A)
None
 1.20A 3tm4A-4eysA:
undetectable		 3tm4A-4eysA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 SER A 176
THR A 178
GLU A  23
ASP A 134
 None
None
AMP  A 401 (-2.9A)
None
 1.17A 3tm4B-4eysA:
undetectable		 3tm4B-4eysA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 280
PHE A 201
VAL A 308
PHE A 339
ALA A 328
 None
 1.33A 3u9fD-4eysA:
undetectable
3u9fE-4eysA:
undetectable		 3u9fD-4eysA:
21.19
3u9fE-4eysA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 280
PHE A 201
VAL A 308
PHE A 339
ALA A 328
 None
 1.37A 3u9fG-4eysA:
undetectable
3u9fH-4eysA:
undetectable		 3u9fG-4eysA:
21.19
3u9fH-4eysA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 LEU A 246
GLY A 207
THR A 112
ILE A 216
 None
 0.56A 3wriA-4eysA:
undetectable		 3wriA-4eysA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 LEU A 246
GLY A 207
THR A 112
ILE A 216
 None
 0.57A 3wriB-4eysA:
undetectable		 3wriB-4eysA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 LEU A  86
ARG A  85
GLY A  79
SER A  12
 None
None
AMP  A 401 (-3.0A)
None
 0.92A 4cp3A-4eysA:
undetectable
4cp3B-4eysA:
undetectable		 4cp3A-4eysA:
16.03
4cp3B-4eysA:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		6 / 6 SER A 109
ASP A 110
SER A 212
ASP A 215
ARG A 221
GLU A 253
 AMP  A 401 (-2.9A)
ACT  A 402 (-4.9A)
ACT  A 402 (-3.2A)
ACT  A 402 ( 4.5A)
ACT  A 402 (-3.6A)
ACT  A 402 ( 3.8A)
 0.55A 4eysA-4eysA:
65.5		 4eysA-4eysA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 GLY A  27
PRO A  38
PHE A  40
ILE A   7
 None
 0.87A 4j4vC-4eysA:
undetectable		 4j4vC-4eysA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 319
GLU A 252
ARG A 184
 AMP  A 401 (-4.0A)
AMP  A 401 (-3.1A)
None
 0.91A 4mwvA-4eysA:
undetectable		 4mwvA-4eysA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 MET A  73
ILE A   5
THR A  83
THR A 111
LEU A 118
 None
 1.18A 4qynA-4eysA:
undetectable		 4qynA-4eysA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 MET A  73
ILE A   5
THR A  83
THR A 111
LEU A 118
 None
 1.17A 4qynB-4eysA:
undetectable		 4qynB-4eysA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 MET A  73
ILE A   5
THR A  83
THR A 111
LEU A 118
 None
 1.14A 4qzuC-4eysA:
undetectable		 4qzuC-4eysA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ASP A 215
MET A 117
PHE A 324
LEU A 213
ILE A 216
 ACT  A 402 ( 4.5A)
None
None
None
None
 1.02A 4x1fA-4eysA:
undetectable		 4x1fA-4eysA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A  57
ASP A  49
PHE A  50
GLY A  13
SER A  44
 None
 1.22A 5hfjG-4eysA:
undetectable		 5hfjG-4eysA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 VAL A  99
ARG A  85
PRO A  88
 None
 0.85A 5koxA-4eysA:
undetectable		 5koxA-4eysA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 PHE A 175
ARG A 184
ASP A 139
GLY A 181
 AMP  A 401 (-3.8A)
None
None
None
 1.18A 5mraA-4eysA:
undetectable
5mraB-4eysA:
undetectable		 5mraA-4eysA:
17.29
5mraB-4eysA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A 256
PRO A 257
LYS A 261
 None
 1.11A 5y9yA-4eysA:
undetectable		 5y9yA-4eysA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 319
PHE A 175
ARG A 184
 AMP  A 401 (-4.0A)
AMP  A 401 (-3.8A)
None
 1.23A 5y9yA-4eysA:
undetectable		 5y9yA-4eysA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4eys MCCC FAMILY PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 PRO A 306
ILE A 305
ILE A 307
ILE A 301
PRO A 236
 None
 1.20A 6hlpA-4eysA:
undetectable		 6hlpA-4eysA:
20.64