SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		3 / 3 CYH A1425
HIS A1428
PHE A1424
 None
 1.07A 3cr4X-4eyuA:
undetectable		 3cr4X-4eyuA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		4 / 4 GLU A1392
GLY A1467
THR A1468
GLU A1415
 NI  A1701 ( 2.6A)
None
None
None
 1.09A 3e9xA-4eyuA:
undetectable		 3e9xA-4eyuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		5 / 12 SER A1385
TYR A1280
ALA A1474
GLY A1406
ASN A1402
 None
 1.19A 3f8wA-4eyuA:
undetectable		 3f8wA-4eyuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		5 / 12 SER A1385
TYR A1280
ALA A1474
GLY A1406
ASN A1402
 None
 1.16A 3f8wC-4eyuA:
undetectable		 3f8wC-4eyuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		5 / 12 SER A1398
PHE A1454
VAL A1462
ALA A1412
HIS A1390
 OGA  A1700 (-2.8A)
None
None
None
NI  A1701 ( 3.3A)
 1.35A 3u9fD-4eyuA:
undetectable
3u9fE-4eyuA:
undetectable		 3u9fD-4eyuA:
16.46
3u9fE-4eyuA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		5 / 12 SER A1398
PHE A1454
VAL A1462
ALA A1412
HIS A1390
 OGA  A1700 (-2.8A)
None
None
None
NI  A1701 ( 3.3A)
 1.32A 3u9fG-4eyuA:
undetectable
3u9fH-4eyuA:
undetectable		 3u9fG-4eyuA:
16.46
3u9fH-4eyuA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		4 / 7 GLU A1625
GLU A1626
TYR A1563
VAL A1618
 None
 1.06A 4a97A-4eyuA:
2.1		 4a97A-4eyuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		4 / 7 GLU A1625
GLU A1626
TYR A1563
VAL A1618
 None
 1.09A 4a97D-4eyuA:
2.2		 4a97D-4eyuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		4 / 7 GLU A1625
GLU A1626
TYR A1563
VAL A1618
 None
 1.00A 4a97H-4eyuA:
undetectable		 4a97H-4eyuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		4 / 7 PHE A1424
GLU A1419
ARG A1427
ILE A1449
 None
 1.28A 4cx7C-4eyuA:
1.1
4cx7D-4eyuA:
undetectable		 4cx7C-4eyuA:
21.92
4cx7D-4eyuA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		3 / 3 ARG A1263
TRP A1257
GLY A1261
 None
 0.66A 4e7cA-4eyuA:
0.8		 4e7cA-4eyuA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		3 / 3 HIS A1470
TRP A1438
SER A1398
 NI  A1701 ( 3.1A)
None
OGA  A1700 (-2.8A)
 1.16A 4lrhD-4eyuA:
undetectable		 4lrhD-4eyuA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		4 / 6 TYR A1622
ASN A1584
GLU A1570
LEU A1619
 None
 1.23A 4twdI-4eyuA:
undetectable
4twdJ-4eyuA:
undetectable		 4twdI-4eyuA:
20.40
4twdJ-4eyuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		4 / 7 GLN A1377
GLY A1372
VAL A1512
SER A1398
 None
None
None
OGA  A1700 (-2.8A)
 0.89A 6hu9S-4eyuA:
undetectable
6hu9q-4eyuA:
undetectable		 6hu9S-4eyuA:
10.74
6hu9q-4eyuA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4eyu LYSINE-SPECIFIC
DEMETHYLASE 6B
(Mus
musculus) 		4 / 6 TYR A1574
GLU A1581
CYH A1539
GLU A1501
 None
 1.25A 6mn5A-4eyuA:
undetectable		 6mn5A-4eyuA:
10.10