SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C4D_D_DVAD8_0 (GRAMICIDIN A)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	3 / 3	TRP A 194 VAL A 163 TRP A 161	None	1.09A	1c4dC-4eyzA: undetectable 1c4dD-4eyzA: undetectable	1c4dC-4eyzA: 9.09 1c4dD-4eyzA: 9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N49_D_RITD401_2 (PROTEASE)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	4 / 6	ASP A 49 GLY A 190 ILE A 218 ILE A 38	None	0.92A	1n49D-4eyzA: undetectable	1n49D-4eyzA: 15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EYZ_A_CCSA109_0 (CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	8 / 8	TYR A 71 ASN A 108 PHE A 112 VAL A 113 HIS A 215 ILE A 216 SER A 231 ALA A 253	CCS A 109 ( 4.6A) CCS A 109 ( 2.6A) None CCS A 109 ( 4.1A) CCS A 109 ( 3.6A) CCS A 109 ( 4.4A) CCS A 109 ( 4.5A) CCS A 109 ( 3.6A)	0.02A	4eyzA-4eyzA: 49.5	4eyzA-4eyzA: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EYZ_B_CCSB109_0 (CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	8 / 8	TYR A 71 ASN A 108 PHE A 112 VAL A 113 HIS A 215 ILE A 216 SER A 231 ALA A 253	CCS A 109 ( 4.6A) CCS A 109 ( 2.6A) None CCS A 109 ( 4.1A) CCS A 109 ( 3.6A) CCS A 109 ( 4.4A) CCS A 109 ( 4.5A) CCS A 109 ( 3.6A)	0.05A	4eyzB-4eyzA: 48.1	4eyzB-4eyzA: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KT0_A_PQNA2001_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	5 / 11	MET A 181 SER A 184 GLY A 185 GLY A 223 LEU A 107	None	1.09A	4kt0A-4eyzA: undetectable 4kt0J-4eyzA: undetectable	4kt0A-4eyzA: 15.33 4kt0J-4eyzA: 9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LB0_A_ACTA401_0 (UNCHARACTERIZED PROTEIN)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	5 / 9	SER A 158 GLY A 157 TYR A 167 GLY A 156 THR A 154	None	1.35A	4lb0A-4eyzA: undetectable	4lb0A-4eyzA: 22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE1_A_X2NA602_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	4 / 5	TYR A 219 ILE A 192 PRO A 249 THR A 61	None	1.17A	4ze1A-4eyzA: 1.0	4ze1A-4eyzA: 16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KVA_B_SAMB301_1 (CAFFEOYL-COA O-METHYLTRANSFERASE)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	3 / 3	THR A 132 SER A 122 ASP A 83	None EDO A 301 ( 3.9A) EDO A 301 (-3.2A)	0.87A	5kvaB-4eyzA: undetectable	5kvaB-4eyzA: 23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_H_SAMH601_0 (NS5 METHYLTRANSFERASE)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	5 / 12	GLY A 223 GLY A 221 VAL A 113 ASP A 191 ILE A 192	None None CCS A 109 ( 4.1A) None None	1.04A	5wz1H-4eyzA: undetectable	5wz1H-4eyzA: 21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HQB_A_PQNA2001_0 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	5 / 10	MET A 181 SER A 184 GLY A 185 GLY A 223 LEU A 107	None	1.12A	6hqbA-4eyzA: undetectable 6hqbJ-4eyzA: undetectable	6hqbA-4eyzA: 15.07 6hqbJ-4eyzA: 9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6I5Z_D_SAMD401_0 (O-METHYLTRANSFERASE 1)	4eyz	CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES (Ruminococcus flavefaciens)	5 / 11	GLY A 223 GLY A 185 LEU A 182 ASP A 226 ASP A 191	None	1.27A	6i5zD-4eyzA: undetectable	6i5zD-4eyzA: 21.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1C4D_D_DVAD8_0","GRAMICIDIN A","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",3,"TRP A 194;VAL A 163;TRP A 161","None","1.09A","1c4dC-4eyzA:undetectable;1c4dD-4eyzA:undetectable","1c4dC-4eyzA:9.09;1c4dD-4eyzA:9.09"],["1N49_D_RITD401_2","PROTEASE","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",4,"ASP A  49;GLY A 190;ILE A 218;ILE A  38","None","0.92A","1n49D-4eyzA:undetectable","1n49D-4eyzA:15.85"],["4EYZ_A_CCSA109_0","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",8,"TYR A  71;ASN A 108;PHE A 112;VAL A 113;HIS A 215;ILE A 216;SER A 231;ALA A 253","CCS A 109 ( 4.6A);CCS A 109 ( 2.6A);None;CCS A 109 ( 4.1A);CCS A 109 ( 3.6A);CCS A 109 ( 4.4A);CCS A 109 ( 4.5A);CCS A 109 ( 3.6A)","0.02A","4eyzA-4eyzA:49.5","4eyzA-4eyzA:100.00"],["4EYZ_B_CCSB109_0","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",8,"TYR A  71;ASN A 108;PHE A 112;VAL A 113;HIS A 215;ILE A 216;SER A 231;ALA A 253","CCS A 109 ( 4.6A);CCS A 109 ( 2.6A);None;CCS A 109 ( 4.1A);CCS A 109 ( 3.6A);CCS A 109 ( 4.4A);CCS A 109 ( 4.5A);CCS A 109 ( 3.6A)","0.05A","4eyzB-4eyzA:48.1","4eyzB-4eyzA:100.00"],["4KT0_A_PQNA2001_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",5,"MET A 181;SER A 184;GLY A 185;GLY A 223;LEU A 107","None","1.09A","4kt0A-4eyzA:undetectable;4kt0J-4eyzA:undetectable","4kt0A-4eyzA:15.33;4kt0J-4eyzA:9.96"],["4LB0_A_ACTA401_0","UNCHARACTERIZED PROTEIN","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",5,"SER A 158;GLY A 157;TYR A 167;GLY A 156;THR A 154","None","1.35A","4lb0A-4eyzA:undetectable","4lb0A-4eyzA:22.62"],["4ZE1_A_X2NA602_2","LANOSTEROL 14-ALPHA DEMETHYLASE","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",4,"TYR A 219;ILE A 192;PRO A 249;THR A  61","None","1.17A","4ze1A-4eyzA:1.0","4ze1A-4eyzA:16.23"],["5KVA_B_SAMB301_1","CAFFEOYL-COA O-METHYLTRANSFERASE","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",3,"THR A 132;SER A 122;ASP A  83","None;EDO A 301 ( 3.9A);EDO A 301 (-3.2A)","0.87A","5kvaB-4eyzA:undetectable","5kvaB-4eyzA:23.79"],["5WZ1_H_SAMH601_0","NS5 METHYLTRANSFERASE","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",5,"GLY A 223;GLY A 221;VAL A 113;ASP A 191;ILE A 192","None;None;CCS A 109 ( 4.1A);None;None","1.04A","5wz1H-4eyzA:undetectable","5wz1H-4eyzA:21.21"],["6HQB_A_PQNA2001_0","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",5,"MET A 181;SER A 184;GLY A 185;GLY A 223;LEU A 107","None","1.12A","6hqbA-4eyzA:undetectable;6hqbJ-4eyzA:undetectable","6hqbA-4eyzA:15.07;6hqbJ-4eyzA:9.96"],["6I5Z_D_SAMD401_0","O-METHYLTRANSFERASE 1","4eyz","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","Ruminococcus flavefaciens",5,"GLY A 223;GLY A 185;LEU A 182;ASP A 226;ASP A 191","None","1.27A","6i5zD-4eyzA:undetectable","6i5zD-4eyzA:21.63"]]