SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ezd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 GLY A  73
ILE A 126
GLY A  79
ILE A 239
ILE A 228
 None
 0.88A 1hshC-4ezdA:
undetectable		 1hshC-4ezdA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 PRO A  70
GLY A  73
LEU A 116
ARG A  59
PHE A  66
 None
None
None
None
SEY  A 402 (-4.8A)
 1.31A 2b9eA-4ezdA:
undetectable		 2b9eA-4ezdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 LEU A 339
LEU A 287
ALA A 288
LEU A 345
PHE A 313
 SPL  A 408 (-3.8A)
None
None
None
None
 1.23A 2oaxB-4ezdA:
undetectable		 2oaxB-4ezdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 LEU A 339
LEU A 287
ALA A 288
LEU A 345
PHE A 313
 SPL  A 408 (-3.8A)
None
None
None
None
 1.30A 2oaxD-4ezdA:
undetectable		 2oaxD-4ezdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 LEU A 339
LEU A 287
ALA A 288
LEU A 345
PHE A 313
 SPL  A 408 (-3.8A)
None
None
None
None
 1.20A 2oaxE-4ezdA:
undetectable		 2oaxE-4ezdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		4 / 7 TYR A 119
PHE A  66
PHE A 296
ASN A 120
 SEY  A 402 (-3.7A)
SEY  A 402 (-4.8A)
None
None
 0.96A 2zseA-4ezdA:
undetectable		 2zseA-4ezdA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		4 / 8 GLY A 238
GLY A 237
GLY A 226
ILE A 228
 BOG  A 405 (-3.6A)
None
None
None
 0.68A 3d41A-4ezdA:
undetectable		 3d41A-4ezdA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 GLY A 266
ILE A 276
ALA A 256
GLY A 262
LEU A 261
 None
 1.00A 3hs6B-4ezdA:
undetectable		 3hs6B-4ezdA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 LEU A 345
GLY A 293
GLY A 294
PRO A 365
ALA A 288
 None
 1.22A 3i5uA-4ezdA:
undetectable		 3i5uA-4ezdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 THR A 314
GLY A 294
LEU A 299
ILE A 244
ILE A 228
 None
 1.05A 3ijdA-4ezdA:
undetectable		 3ijdA-4ezdA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 10 VAL A 124
VAL A 145
LEU A 142
GLY A 125
TRP A  86
 None
 1.16A 3ls4H-4ezdA:
undetectable		 3ls4H-4ezdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		3 / 3 PRO A 336
THR A 334
LEU A 287
 None
SEY  A 401 ( 4.7A)
None
 0.75A 3ttrA-4ezdA:
undetectable		 3ttrA-4ezdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		4 / 6 LEU A 159
ASN A 160
LEU A 342
ILE A 359
 None
None
SPL  A 408 ( 4.5A)
None
 0.91A 4okxA-4ezdA:
undetectable		 4okxA-4ezdA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		4 / 7 LEU A 345
THR A 341
PRO A 169
LEU A 287
 None
 0.95A 5fxtA-4ezdA:
undetectable		 5fxtA-4ezdA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		3 / 3 ILE A  71
PRO A  70
ILE A  74
 None
 0.45A 5hw8F-4ezdA:
undetectable		 5hw8F-4ezdA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		4 / 6 SER A 248
GLY A 294
ASN A 368
ILE A 290
 None
 1.08A 5j4nA-4ezdA:
undetectable		 5j4nA-4ezdA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 GLY A 333
VAL A  64
ILE A 228
GLY A 230
ILE A 130
 SEY  A 401 (-3.6A)
None
None
SEY  A 401 ( 4.0A)
None
 0.92A 6dj1B-4ezdA:
undetectable		 6dj1B-4ezdA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4ezd UREA TRANSPORTER 1
(Bos
taurus) 		5 / 12 GLY A 333
VAL A  64
ILE A 228
GLY A 230
ILE A 130
 SEY  A 401 (-3.6A)
None
None
SEY  A 401 ( 4.0A)
None
 0.95A 6dj2B-4ezdA:
undetectable		 6dj2B-4ezdA:
12.26