SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4eze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		4 / 6 GLY A 249
ASP A 252
GLY A 181
SER A  95
 None
NA  A 302 ( 4.3A)
None
None
 0.91A 1eswA-4ezeA:
undetectable		 1eswA-4ezeA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 10 ILE A 263
PHE A  77
ASN A 280
SER A  69
ILE A 279
 None
 1.13A 1j3jA-4ezeA:
3.2		 1j3jA-4ezeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 10 LYS A 225
ILE A 275
ASN A 280
ASP A 248
GLY A 249
 None
None
None
NA  A 302 (-2.8A)
None
 1.50A 1jujA-4ezeA:
undetectable		 1jujA-4ezeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 10 LYS A 225
ILE A 275
ASN A 280
ASP A 248
GLY A 249
 None
None
None
NA  A 302 (-2.8A)
None
 1.50A 1jujB-4ezeA:
undetectable		 1jujB-4ezeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 10 LYS A 225
ILE A 275
ASN A 280
ASP A 248
GLY A 249
 None
None
None
NA  A 302 (-2.8A)
None
 1.50A 1jujC-4ezeA:
undetectable		 1jujC-4ezeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 10 LYS A 225
ILE A 275
ASN A 280
ASP A 248
GLY A 249
 None
None
None
NA  A 302 (-2.8A)
None
 1.50A 1jujD-4ezeA:
undetectable		 1jujD-4ezeA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		4 / 7 LEU A 141
ILE A 119
ARG A 136
SER A 133
 None
 1.12A 2hc4A-4ezeA:
undetectable		 2hc4A-4ezeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 11 GLY A 260
THR A 261
GLY A 262
HIS A 277
PHE A  76
 None
 1.14A 2hmaA-4ezeA:
undetectable		 2hmaA-4ezeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		4 / 6 ILE A 275
PRO A  84
LEU A 287
ILE A 244
 None
 1.04A 2q83B-4ezeA:
undetectable		 2q83B-4ezeA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		3 / 3 THR A  96
SER A 180
LYS A 225
 None
 1.14A 3aocC-4ezeA:
3.6		 3aocC-4ezeA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 12 THR A 212
ASN A 209
ASP A 208
ILE A 138
GLY A 139
 None
 1.18A 3eeyA-4ezeA:
2.3		 3eeyA-4ezeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 12 THR A 212
ASN A 209
ASP A 208
ILE A 138
GLY A 139
 None
 1.17A 3eeyF-4ezeA:
2.2		 3eeyF-4ezeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 10 ILE A 165
ILE A   3
TYR A   5
LEU A 295
ILE A  12
 None
 1.18A 3prsA-4ezeA:
undetectable		 3prsA-4ezeA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_D_SAMD800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 10 ILE A 165
GLU A 292
GLY A  87
ASN A  86
LYS A 172
 None
 1.29A 4e47D-4ezeA:
undetectable		 4e47D-4ezeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 12 LEU A 211
LEU A 141
SER A 113
THR A 117
VAL A 152
 None
 1.18A 4f4dB-4ezeA:
undetectable		 4f4dB-4ezeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 11 ILE A 165
GLU A 292
GLY A  87
ASN A  86
LYS A 172
 None
 1.35A 4j83A-4ezeA:
undetectable		 4j83A-4ezeA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 11 ILE A 165
GLU A 292
GLY A  87
ASN A  86
LYS A 172
 None
 1.28A 4jdsC-4ezeA:
undetectable		 4jdsC-4ezeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 12 THR A  45
ALA A  40
LEU A  42
LEU A 295
LEU A 286
 None
 1.31A 4xi3D-4ezeA:
undetectable		 4xi3D-4ezeA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		4 / 5 ASN A 251
SER A 133
ASP A 104
GLU A 101
 None
 1.29A 4zjlA-4ezeA:
3.5		 4zjlA-4ezeA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 10 ARG A 108
ALA A 107
GLY A 102
ASP A  94
VAL A 152
 None
 1.27A 6clxB-4ezeA:
2.7		 6clxB-4ezeA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE
(Salmonella
enterica) 		5 / 9 PRO A 145
VAL A 152
LEU A 110
GLU A 109
ILE A 106
 None
 1.35A 6fdyU-4ezeA:
undetectable		 6fdyU-4ezeA:
21.13