SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ezi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 TYR A  70
VAL A 100
ILE A 185
LEU A  34
 None
 1.13A 1j96A-4eziA:
undetectable		 1j96A-4eziA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 10 GLY A 197
LEU A 385
TYR A 105
THR A 201
GLY A 198
 None
 1.27A 1kvlA-4eziA:
undetectable		 1kvlA-4eziA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 ASP A 288
LEU A 291
HIS A 381
 None
 0.60A 1qknA-4eziA:
undetectable		 1qknA-4eziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 PHE A 265
PHE A 306
LEU A 321
PHE A 269
 None
 1.19A 1wrlE-4eziA:
undetectable		 1wrlE-4eziA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 SER A 104
VAL A 217
LEU A 189
 None
 0.53A 1yajG-4eziA:
13.4		 1yajG-4eziA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 ILE A 202
THR A 333
ALA A 334
TYR A 227
SER A 363
 None
 1.43A 2gl0A-4eziA:
0.7
2gl0C-4eziA:
undetectable		 2gl0A-4eziA:
18.41
2gl0C-4eziA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 SER A 363
ILE A 202
THR A 333
ALA A 334
TYR A 227
 None
 1.35A 2gl0D-4eziA:
undetectable
2gl0E-4eziA:
undetectable		 2gl0D-4eziA:
18.41
2gl0E-4eziA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 PRO A 222
ALA A 225
LEU A 338
ALA A 355
 None
 0.95A 2vcvB-4eziA:
undetectable		 2vcvB-4eziA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		6 / 9 PRO A 222
LEU A 336
ALA A 225
LEU A 338
ALA A 355
PHE A 359
 None
 1.37A 2vcvD-4eziA:
undetectable		 2vcvD-4eziA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		6 / 9 PRO A 222
LEU A 336
ALA A 225
LEU A 338
ALA A 355
PHE A 359
 None
 1.34A 2vcvE-4eziA:
undetectable		 2vcvE-4eziA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		6 / 9 PRO A 222
LEU A 336
ALA A 225
LEU A 338
ALA A 355
PHE A 359
 None
 1.33A 2vcvH-4eziA:
undetectable		 2vcvH-4eziA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 9 PRO A 222
LEU A 336
ALA A 225
LEU A 338
ALA A 355
 None
 1.13A 2vcvI-4eziA:
undetectable		 2vcvI-4eziA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 PRO A  93
GLY A 136
TYR A  65
 None
 0.67A 2vouA-4eziA:
undetectable		 2vouA-4eziA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 PRO A  93
GLY A 136
TYR A  65
 None
 0.66A 2vouB-4eziA:
undetectable		 2vouB-4eziA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 PRO A  93
GLY A 136
TYR A  65
 None
 0.67A 2vouC-4eziA:
undetectable		 2vouC-4eziA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 GLU A 196
SER A 200
VAL A 158
VAL A 203
 None
 1.26A 3n61A-4eziA:
undetectable
3n61B-4eziA:
0.6		 3n61A-4eziA:
20.88
3n61B-4eziA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 ILE A 103
ALA A 192
THR A 201
LEU A 215
LEU A 171
 None
 1.15A 3s79A-4eziA:
undetectable		 3s79A-4eziA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 5 LEU A  67
ALA A 129
MET A 141
ASN A 124
 None
 1.12A 3uq6A-4eziA:
undetectable		 3uq6A-4eziA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 5 LEU A  67
ALA A 129
MET A 141
THR A 139
 None
 1.28A 3vasB-4eziA:
undetectable		 3vasB-4eziA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 LEU A 385
GLY A 108
TYR A 194
SER A 195
 None
None
None
PEG  A 501 ( 3.9A)
 0.92A 4cp3A-4eziA:
undetectable
4cp3B-4eziA:
undetectable		 4cp3A-4eziA:
16.80
4cp3B-4eziA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 11 SER A 370
GLY A 340
VAL A 384
GLU A 387
ASP A 344
 None
 1.28A 4d9hA-4eziA:
3.3		 4d9hA-4eziA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 LYS A 313
THR A 318
ILE A 323
 CL  A 502 ( 3.9A)
None
None
 0.86A 4e0fB-4eziA:
undetectable		 4e0fB-4eziA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 PHE A 269
GLY A 309
ILE A 311
PHE A 302
LEU A 248
 None
None
None
None
PEG  A 501 ( 4.8A)
 1.34A 4kotA-4eziA:
2.8		 4kotA-4eziA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 5 GLY A 241
ARG A 345
GLU A 239
PHE A 235
 None
 1.33A 4r82A-4eziA:
undetectable
4r82B-4eziA:
undetectable		 4r82A-4eziA:
19.52
4r82B-4eziA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 6 ILE A 102
ALA A  91
THR A 139
VAL A  90
VAL A 100
 None
 1.18A 5eclD-4eziA:
undetectable		 5eclD-4eziA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 201
TYR A 144
GLY A 108
TYR A 127
 None
 1.10A 5hwaA-4eziA:
undetectable		 5hwaA-4eziA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 5 PRO A 222
HIS A 327
TYR A 157
PHE A 251
 None
None
None
PEG  A 501 (-4.6A)
 1.37A 5igjA-4eziA:
undetectable		 5igjA-4eziA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 ILE A 103
ALA A 192
THR A 201
LEU A 215
LEU A 171
 None
 1.14A 5jkvA-4eziA:
undetectable		 5jkvA-4eziA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 THR A 257
SER A 254
TYR A 253
 None
 0.88A 5jsdA-4eziA:
undetectable		 5jsdA-4eziA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 THR A 257
SER A 254
TYR A 253
 None
 0.88A 5jsdC-4eziA:
undetectable		 5jsdC-4eziA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 4 GLU A 279
PRO A 278
ILE A 277
LEU A 276
 None
 1.18A 5m45A-4eziA:
undetectable		 5m45A-4eziA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 4 GLU A 279
PRO A 278
ILE A 277
LEU A 276
 None
 1.26A 5m45D-4eziA:
undetectable		 5m45D-4eziA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 4 GLU A 279
PRO A 278
ILE A 277
LEU A 276
 None
 1.18A 5m45G-4eziA:
undetectable		 5m45G-4eziA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 4 GLU A 279
PRO A 278
ILE A 277
LEU A 276
 None
 1.27A 5m45J-4eziA:
undetectable		 5m45J-4eziA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 GLU A 196
SER A 200
PRO A 156
GLY A 146
LEU A 145
 None
 1.29A 5m50B-4eziA:
4.5		 5m50B-4eziA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 245
LEU A 248
VAL A 158
TYR A 157
 None
PEG  A 501 ( 4.8A)
None
None
 1.04A 5ov9A-4eziA:
5.4		 5ov9A-4eziA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 8 THR A 245
LEU A 248
VAL A 158
TYR A 157
 None
PEG  A 501 ( 4.8A)
None
None
 1.02A 5ov9B-4eziA:
14.4		 5ov9B-4eziA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 PRO A 240
LEU A 300
PHE A 302
LEU A 294
 None
 1.20A 5tl8A-4eziA:
undetectable		 5tl8A-4eziA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 GLY A 146
LEU A 147
HIS A 155
 None
 0.48A 5u63A-4eziA:
undetectable		 5u63A-4eziA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 GLY A 146
LEU A 147
HIS A 155
 None
 0.46A 5u63B-4eziA:
undetectable		 5u63B-4eziA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ezi UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 TYR A  37
ILE A  72
ALA A 178
ARG A 180
 None
 1.15A 6hu9m-4eziA:
undetectable
6hu9q-4eziA:
undetectable		 6hu9m-4eziA:
22.00
6hu9q-4eziA:
17.02