SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGP_A_PCFA1213_0 (WNT INHIBITORY FACTOR 1)	4f02	POLYADENYLATE-BINDIN G PROTEIN 1 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1 (Homo sapiens; Homo sapiens)	5 / 12	ILE C 182 ILE C 180 MET A 158 PHE A 145 VAL A 130	None	1.09A	2ygpA-4f02C: undetectable	2ygpA-4f02C: 7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGP_A_PCFA1213_0 (WNT INHIBITORY FACTOR 1)	4f02	POLYADENYLATE-BINDIN G PROTEIN 1 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1 (Homo sapiens; Homo sapiens)	5 / 12	ILE C 182 ILE C 180 MET A 158 PHE A 145 VAL A 143	None	1.16A	2ygpA-4f02C: undetectable	2ygpA-4f02C: 7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EYZ_A_CCSA109_0 (CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES)	4f02	POLYADENYLATE-BINDIN G PROTEIN 1 (Homo sapiens)	4 / 8	ASN A 105 PHE A 169 VAL A 170 ILE A 103	A B 2 (-3.8A) A B 3 ( 4.7A) None None	1.01A	4eyzA-4f02A: undetectable	4eyzA-4f02A: 23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UC1_B_486B801_1 (GLUCOCORTICOID RECEPTOR)	4f02	POLYADENYLATE-BINDIN G PROTEIN 1 (Homo sapiens)	3 / 3	TRP A 86 MET A 85 ASN A 73	None A B 6 (-3.3A) None	1.22A	5uc1A-4f02A: undetectable	5uc1A-4f02A: 16.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2YGP_A_PCFA1213_0","WNT INHIBITORY FACTOR 1","4f02","POLYADENYLATE-BINDING PROTEIN 1;EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1","Homo sapiens;Homo sapiens",5,"ILE C 182;ILE C 180;MET A 158;PHE A 145;VAL A 130","None","1.09A","2ygpA-4f02C:undetectable","2ygpA-4f02C:7.65"],["2YGP_A_PCFA1213_0","WNT INHIBITORY FACTOR 1","4f02","POLYADENYLATE-BINDING PROTEIN 1;EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1","Homo sapiens;Homo sapiens",5,"ILE C 182;ILE C 180;MET A 158;PHE A 145;VAL A 143","None","1.16A","2ygpA-4f02C:undetectable","2ygpA-4f02C:7.65"],["4EYZ_A_CCSA109_0","CELLULOSOME-RELATED PROTEIN MODULE FROM RUMINOCOCCUS FLAVEFACIENS THAT RESEMBLES PAPAIN-LIKE CYSTEINE PEPTIDASES","4f02","POLYADENYLATE-BINDING PROTEIN 1","Homo sapiens",4,"ASN A 105;PHE A 169;VAL A 170;ILE A 103","  A B   2 (-3.8A);  A B   3 ( 4.7A);None;None","1.01A","4eyzA-4f02A:undetectable","4eyzA-4f02A:23.28"],["5UC1_B_486B801_1","GLUCOCORTICOID RECEPTOR;GLUCOCORTICOID RECEPTOR","4f02","POLYADENYLATE-BINDING PROTEIN 1","Homo sapiens",3,"TRP A  86;MET A  85;ASN A  73","None;  A B   6 (-3.3A);None","1.22A","5uc1A-4f02A:undetectable","5uc1A-4f02A:16.35"]]