SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		4 / 7 GLY B 206
ALA B  95
ILE B  92
THR B 176
 None
 0.83A 1gtnA-4f0aB:
undetectable
1gtnK-4f0aB:
undetectable		 1gtnA-4f0aB:
13.38
1gtnK-4f0aB:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 12 THR B 176
GLY B 169
ILE B 205
GLU B  85
PHE B  59
 None
 1.47A 1vq1A-4f0aB:
undetectable		 1vq1A-4f0aB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 11 VAL B 148
LEU B 151
VAL B  44
GLY B  47
ALA B  48
 None
 1.21A 3pghB-4f0aB:
1.3		 3pghB-4f0aB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 12 VAL B 148
LEU B 151
VAL B  44
GLY B  47
ALA B  48
 None
 1.08A 3rr3A-4f0aB:
undetectable		 3rr3A-4f0aB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 12 VAL B 148
LEU B 151
VAL B  44
GLY B  47
ALA B  48
 None
 1.07A 3rr3B-4f0aB:
1.8		 3rr3B-4f0aB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 12 VAL B 148
LEU B 151
VAL B  44
GLY B  47
ALA B  48
 None
 1.07A 3rr3C-4f0aB:
1.7		 3rr3C-4f0aB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 12 VAL B 148
LEU B 151
VAL B  44
GLY B  47
ALA B  48
 None
 1.07A 3rr3D-4f0aB:
1.5		 3rr3D-4f0aB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		4 / 8 ASP B 204
ILE B 205
PHE B 202
GLY B  96
 None
 0.81A 4acbC-4f0aB:
undetectable		 4acbC-4f0aB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 12 ASN B 207
ASP B 204
ILE B 205
ALA B 172
VAL B 173
 None
 0.93A 4dx5B-4f0aB:
2.7		 4dx5B-4f0aB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		4 / 8 VAL B 245
ILE B 251
SER B 248
ALA B  91
 None
 0.89A 4eyzA-4f0aB:
undetectable		 4eyzA-4f0aB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		4 / 8 VAL B 245
ILE B 251
SER B 248
ALA B  91
 None
 0.88A 4eyzB-4f0aB:
undetectable		 4eyzB-4f0aB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 12 ASN B 207
ASP B 204
ILE B 205
ALA B 172
VAL B 173
 None
 0.96A 4u8vB-4f0aB:
undetectable		 4u8vB-4f0aB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 12 ASN B 207
ASP B 204
ILE B 205
ALA B 172
VAL B 173
 None
 0.94A 4u8yB-4f0aB:
2.8		 4u8yB-4f0aB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 12 ASN B 207
ASP B 204
ILE B 205
ALA B 172
VAL B 173
 None
 0.95A 4u95B-4f0aB:
undetectable		 4u95B-4f0aB:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		5 / 10 LEU B  73
SER B 144
GLY B  47
VAL B  97
VAL B  44
 None
 1.31A 4yb6B-4f0aB:
undetectable
4yb6F-4f0aB:
undetectable		 4yb6B-4f0aB:
21.08
4yb6F-4f0aB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		3 / 3 SER B 106
GLU B 201
GLU B  54
 None
 0.82A 4ymgB-4f0aB:
undetectable		 4ymgB-4f0aB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		4 / 7 SER B 244
HIS B 164
GLY B 247
LEU B 219
 None
 1.13A 6btxA-4f0aB:
1.8		 6btxA-4f0aB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4f0a PROTEIN WNT-8
(Xenopus
laevis) 		4 / 6 SER B 144
ALA B  48
THR B  70
ALA B  74
 None
 1.16A 6ma6A-4f0aB:
undetectable		 6ma6A-4f0aB:
12.34