SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		6 / 7 HIS A 152
GLY A 153
TYR A 182
LEU A 189
ALA A 190
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 ( 4.7A)
3AB  A 301 (-3.9A)
3AB  A 301 (-3.8A)
 0.37A 1dmaA-4f0dA:
4.7		 1dmaA-4f0dA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 6 HIS A 152
GLY A 153
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.47A 1dmaB-4f0dA:
4.8		 1dmaB-4f0dA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 8 CYH A 215
LEU A 187
ALA A 190
LEU A 191
 None
None
3AB  A 301 (-3.9A)
None
 0.74A 1hwiD-4f0dA:
undetectable		 1hwiD-4f0dA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 6 LEU A 204
ALA A  20
LEU A  18
SER A  99
 None
 1.08A 1ictB-4f0dA:
undetectable		 1ictB-4f0dA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 8 HIS A 152
GLY A 153
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.42A 3u9hA-4f0dA:
10.5		 3u9hA-4f0dA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 8 HIS A 152
GLY A 153
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.46A 3u9hB-4f0dA:
10.4		 3u9hB-4f0dA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		5 / 6 HIS A 152
GLY A 153
TYR A 182
ALA A 190
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.9A)
3AB  A 301 (-3.8A)
 0.43A 4ae1A-4f0dA:
5.0		 4ae1A-4f0dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 5 HIS A 152
GLY A 153
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.34A 4ae1B-4f0dA:
4.6		 4ae1B-4f0dA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 8 HIS A 152
GLY A 153
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.33A 4bjcA-4f0dA:
10.7		 4bjcA-4f0dA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 7 HIS A 152
GLY A 153
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.60A 4hyfA-4f0dA:
10.2		 4hyfA-4f0dA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 8 HIS A 152
GLY A 153
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.57A 4hyfB-4f0dA:
10.3		 4hyfB-4f0dA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 8 HIS A 152
GLY A 153
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
3AB  A 301 (-3.4A)
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.54A 4hyfC-4f0dA:
10.4		 4hyfC-4f0dA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 6 LEU A  95
GLU A 127
VAL A 214
ALA A 213
 None
 1.09A 4nkvC-4f0dA:
undetectable		 4nkvC-4f0dA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 6 SER A 210
HIS A 196
PRO A 195
LEU A 191
 None
 1.13A 5dzka-4f0dA:
undetectable
5dzko-4f0dA:
undetectable		 5dzka-4f0dA:
19.23
5dzko-4f0dA:
0.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		4 / 7 SER A 210
HIS A 196
PRO A 195
LEU A 191
 None
 1.16A 5dzkD-4f0dA:
undetectable
5dzkR-4f0dA:
undetectable		 5dzkD-4f0dA:
19.23
5dzkR-4f0dA:
0.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4f0d POLY [ADP-RIBOSE]
POLYMERASE 16
(Homo
sapiens) 		6 / 9 HIS A 152
SER A 154
ASN A 158
ILE A 162
TYR A 182
TYR A 193
 3AB  A 301 (-4.0A)
None
None
None
3AB  A 301 (-4.3A)
3AB  A 301 (-3.8A)
 0.72A 5ha9B-4f0dA:
11.9		 5ha9B-4f0dA:
25.73