SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		4 / 7 HIS A 537
GLY A 538
TYR A 569
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
0RU  A 701 (-3.7A)
 0.30A 1dmaA-4f0eA:
5.1		 1dmaA-4f0eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 6 HIS A 537
GLY A 538
TYR A 569
ALA A 571
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.7A)
 0.43A 1dmaB-4f0eA:
4.9		 1dmaB-4f0eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 12 MET A 593
ALA A 571
ILE A 503
PHE A 638
ARG A 533
 None
 1.15A 1eiiA-4f0eA:
undetectable		 1eiiA-4f0eA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		4 / 8 VAL A 598
ARG A 554
GLY A 567
ALA A 557
 None
 0.78A 2xfsA-4f0eA:
undetectable		 2xfsA-4f0eA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		4 / 8 VAL A 598
ARG A 554
GLY A 567
ALA A 557
 None
 0.78A 2xh9A-4f0eA:
undetectable		 2xh9A-4f0eA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		3 / 3 HIS A 463
ARG A 505
GLU A 649
 None
 1.01A 3qf1A-4f0eA:
undetectable		 3qf1A-4f0eA:
15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.50A 3u9hA-4f0eA:
19.7		 3u9hA-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 8 HIS A 537
GLY A 538
LYS A 579
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 1.49A 3u9hB-4f0eA:
19.5		 3u9hB-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.51A 3u9hB-4f0eA:
19.5		 3u9hB-4f0eA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		4 / 6 HIS A 537
GLY A 538
TYR A 569
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
0RU  A 701 (-3.7A)
 0.30A 4ae1A-4f0eA:
6.1		 4ae1A-4f0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		4 / 5 HIS A 537
GLY A 538
TYR A 569
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
0RU  A 701 (-3.7A)
 0.25A 4ae1B-4f0eA:
5.6		 4ae1B-4f0eA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.39A 4bjcA-4f0eA:
19.0		 4bjcA-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 7 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.61A 4hyfA-4f0eA:
19.9		 4hyfA-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 8 HIS A 537
GLY A 538
LYS A 579
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 1.48A 4hyfB-4f0eA:
19.9		 4hyfB-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.62A 4hyfB-4f0eA:
19.9		 4hyfB-4f0eA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 8 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.59A 4hyfC-4f0eA:
19.9		 4hyfC-4f0eA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 11 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.43A 4rv6A-4f0eA:
17.4		 4rv6A-4f0eA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		6 / 11 HIS A 537
GLY A 538
TYR A 569
ALA A 571
SER A 577
TYR A 582
 0RU  A 701 (-3.7A)
0RU  A 701 (-3.3A)
0RU  A 701 (-4.3A)
None
0RU  A 701 (-3.5A)
0RU  A 701 (-3.7A)
 0.44A 4rv6B-4f0eA:
17.5		 4rv6B-4f0eA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 11 GLY A 589
LYS A 584
ASP A 540
ALA A 541
SER A 587
 None
None
0RU  A 701 (-3.3A)
None
None
 1.12A 5x6yC-4f0eA:
undetectable		 5x6yC-4f0eA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4f0e POLY [ADP-RIBOSE]
POLYMERASE 15
(Homo
sapiens) 		5 / 12 LEU A 535
MET A 522
VAL A 598
THR A 568
GLY A 567
 None
 1.07A 6brdA-4f0eA:
undetectable		 6brdA-4f0eA:
18.06