SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 ALA A1053
GLU A1078
MET A1082
PHE A1107
GLY A1111
ALA A1176
 None
 1.10A 1iepB-4f0gA:
26.3		 1iepB-4f0gA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 VAL A1040
ALA A1053
GLU A1078
PHE A1107
GLY A1111
ALA A1176
 None
 0.82A 1iepB-4f0gA:
26.3		 1iepB-4f0gA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		5 / 12 ILE A1256
PRO A1257
ASP A1259
ILE A1268
LYS A1129
 None
 1.45A 1kijA-4f0gA:
undetectable		 1kijA-4f0gA:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		7 / 12 ALA A1053
GLU A1078
MET A1082
VAL A1091
PHE A1107
GLY A1111
ALA A1176
 None
 1.04A 1opjB-4f0gA:
26.1		 1opjB-4f0gA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		7 / 12 VAL A1040
ALA A1053
GLU A1078
VAL A1091
PHE A1107
GLY A1111
ALA A1176
 None
 0.80A 1opjB-4f0gA:
26.1		 1opjB-4f0gA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		4 / 7 ASN A1159
HIS A1152
PHE A1178
ILE A1136
 None
 1.34A 1tdnA-4f0gA:
undetectable		 1tdnA-4f0gA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		4 / 7 TYR A1028
VAL A1104
THR A1020
ASP A1023
 None
 0.90A 2a1mA-4f0gA:
undetectable		 2a1mA-4f0gA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		5 / 12 PHE A1219
ALA A1199
ASN A1194
ILE A1140
ILE A1136
 None
 1.17A 2bjfA-4f0gA:
undetectable		 2bjfA-4f0gA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		7 / 12 VAL A1040
ALA A1053
GLU A1078
VAL A1091
PHE A1107
GLY A1111
ALA A1176
 None
 0.83A 2hyyC-4f0gA:
26.8		 2hyyC-4f0gA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		4 / 7 ILE A1140
ARG A1153
PHE A1178
ILE A1081
 None
 1.25A 2qb4A-4f0gA:
undetectable		 2qb4A-4f0gA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		4 / 6 PHE A1219
LEU A1264
LEU A1134
ALA A1137
 None
 0.95A 2vcvB-4f0gA:
undetectable		 2vcvB-4f0gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		4 / 6 VAL A1052
VAL A1051
GLN A1163
ARG A1044
 None
 1.23A 3bjwF-4f0gA:
undetectable		 3bjwF-4f0gA:
16.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 VAL A1040
ALA A1053
GLU A1078
PHE A1107
GLY A1111
ALA A1176
 None
 0.76A 3k5vA-4f0gA:
20.9		 3k5vA-4f0gA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		4 / 8 SER A1127
CYH A1172
LEU A1165
ASP A1166
 None
 1.06A 3m0wE-4f0gA:
1.1
3m0wF-4f0gA:
undetectable
3m0wG-4f0gA:
1.0
3m0wH-4f0gA:
0.9		 3m0wE-4f0gA:
16.06
3m0wF-4f0gA:
16.06
3m0wG-4f0gA:
16.06
3m0wH-4f0gA:
16.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 ALA A1053
GLU A1078
MET A1082
PHE A1107
GLY A1111
ALA A1176
 None
 1.05A 3mssD-4f0gA:
26.3		 3mssD-4f0gA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		4 / 7 MET A1143
LEU A1085
LEU A1155
PHE A1282
 None
 1.28A 3nk2X-4f0gA:
undetectable		 3nk2X-4f0gA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 ALA A1053
GLU A1078
VAL A1091
GLY A1111
HIS A1152
ALA A1176
 None
 0.70A 3oxzA-4f0gA:
21.3		 3oxzA-4f0gA:
30.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		4 / 5 LYS A1055
ILE A1081
VAL A1091
ASP A1177
 None
 1.17A 3wzdA-4f0gA:
26.7		 3wzdA-4f0gA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		5 / 9 ILE A1081
MET A1082
LEU A1085
ILE A1090
MET A1103
 None
 0.77A 3zosA-4f0gA:
25.5		 3zosA-4f0gA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		5 / 9 ILE A1081
MET A1082
LEU A1085
ILE A1090
MET A1103
 None
 0.77A 3zosB-4f0gA:
19.6		 3zosB-4f0gA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 ALA A1053
GLU A1078
ILE A1081
MET A1082
MET A1103
ALA A1176
 None
 0.62A 4bkjA-4f0gA:
19.4		 4bkjA-4f0gA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 VAL A1040
ALA A1053
GLU A1078
ILE A1081
MET A1103
ALA A1176
 None
 0.59A 4bkjA-4f0gA:
19.4		 4bkjA-4f0gA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 VAL A1040
ALA A1053
GLU A1078
ILE A1081
MET A1103
ALA A1176
 None
 0.59A 4bkjB-4f0gA:
19.5		 4bkjB-4f0gA:
29.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 VAL A1040
ALA A1053
GLU A1078
ILE A1081
VAL A1091
ALA A1176
 None
 0.56A 4csvA-4f0gA:
22.2		 4csvA-4f0gA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		4 / 7 PHE A1219
GLY A1139
ILE A1160
LEU A1155
 None
 0.87A 4ejjD-4f0gA:
undetectable		 4ejjD-4f0gA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		3 / 3 MET A1246
MET A1198
TYR A1236
 None
 1.33A 4p6xI-4f0gA:
undetectable		 4p6xI-4f0gA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		5 / 12 GLU A1235
ILE A1256
PRO A1257
ASP A1259
ILE A1268
 None
 1.18A 4uroA-4f0gA:
undetectable		 4uroA-4f0gA:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 GLY A1033
GLY A1035
PHE A1037
VAL A1040
ALA A1053
LYS A1055
 None
 1.06A 5hieC-4f0gA:
26.6		 5hieC-4f0gA:
30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4
(Dictyostelium
discoideum) 		6 / 12 GLY A1033
PHE A1037
VAL A1040
ALA A1053
LYS A1055
PHE A1161
 None
 1.07A 5hieC-4f0gA:
26.6		 5hieC-4f0gA:
30.56