SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 8 LEU A 511
ALA A 526
VAL A 540
VAL A 587
None
0.88A 1epbB-4f0iA:
undetectable
1epbB-4f0iA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 6 LYS A 543
VAL A 572
MET A 591
ARG A 648
None
0.89A 1iepA-4f0iA:
27.6
1iepA-4f0iA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 6 LEU A 515
LYS A 543
MET A 591
ARG A 648
None
1.01A 1opjB-4f0iA:
26.5
1opjB-4f0iA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 9 LEU A 515
VAL A 523
ALA A 541
GLY A 594
LEU A 656
None
0.32A 1xbbA-4f0iA:
30.5
1xbbA-4f0iA:
32.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_A_SPMA653_1
(CLASS B ACID
PHOSPHATASE)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 9 ASP A 673
GLY A 669
ASP A 667
THR A 677
TYR A 679
None
1.43A 2b8jA-4f0iA:
0.0
2b8jA-4f0iA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
VAL A 523
ALA A 541
LYS A 543
VAL A 572
GLY A 594
LEU A 656
None
0.55A 2gqgB-4f0iA:
29.6
2gqgB-4f0iA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 12 VAL A 523
ALA A 541
TYR A 590
MET A 591
GLY A 594
ASP A 667
None
0.75A 2wgjA-4f0iA:
33.4
2wgjA-4f0iA:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 9 LEU A 515
VAL A 523
ALA A 541
MET A 591
GLY A 594
LEU A 656
GLY A 666
ASP A 667
None
0.65A 2xp2A-4f0iA:
30.7
2xp2A-4f0iA:
39.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 12 VAL A 523
ALA A 541
PHE A 588
MET A 591
GLY A 594
LEU A 656
None
0.43A 2y7jA-4f0iA:
17.2
2y7jA-4f0iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 10 VAL A 523
ALA A 541
PHE A 588
MET A 591
GLY A 594
LEU A 656
None
0.40A 2y7jB-4f0iA:
17.2
2y7jB-4f0iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 10 VAL A 523
ALA A 541
PHE A 588
MET A 591
GLY A 594
LEU A 656
None
0.43A 2y7jC-4f0iA:
17.2
2y7jC-4f0iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 10 VAL A 523
ALA A 541
PHE A 588
MET A 591
GLY A 594
LEU A 656
None
0.39A 2y7jD-4f0iA:
17.1
2y7jD-4f0iA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 10 LEU A 515
ALA A 541
VAL A 572
MET A 591
GLY A 594
LEU A 656
None
0.49A 3aoxA-4f0iA:
25.2
3aoxA-4f0iA:
37.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 9 LEU A 515
VAL A 523
LYS A 543
VAL A 572
LEU A 656
None
0.92A 3cs9B-4f0iA:
31.1
3cs9B-4f0iA:
36.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 11 LEU A 515
VAL A 523
ALA A 541
TYR A 590
GLY A 594
ASP A 595
LEU A 656
None
0.79A 3g0fA-4f0iA:
32.0
3g0fA-4f0iA:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 10 LEU A 515
VAL A 523
ALA A 541
TYR A 590
GLY A 594
LEU A 656
None
0.74A 3g0fB-4f0iA:
32.6
3g0fB-4f0iA:
35.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 6 SER A 711
PHE A 712
ILE A 773
PHE A 645
None
1.01A 3ko0S-4f0iA:
undetectable
3ko0S-4f0iA:
17.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 11 ALA A 541
VAL A 572
PHE A 588
MET A 591
GLY A 594
LEU A 656
None
0.50A 3miyA-4f0iA:
25.2
3miyA-4f0iA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 9 ALA A 541
PHE A 588
MET A 591
GLY A 594
LEU A 656
None
0.34A 3miyB-4f0iA:
31.8
3miyB-4f0iA:
38.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 7 LYS A 543
VAL A 572
MET A 591
ARG A 648
None
0.81A 3mssB-4f0iA:
27.7
3mssB-4f0iA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 6 VAL A 523
LYS A 543
VAL A 572
MET A 591
None
0.74A 3mssD-4f0iA:
27.6
3mssD-4f0iA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
LEU A 656
None
0.61A 3sxrB-4f0iA:
23.3
3sxrB-4f0iA:
37.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 9 ALA A 541
VAL A 572
PHE A 588
ASP A 595
LEU A 656
None
0.52A 3ti1A-4f0iA:
21.8
3ti1A-4f0iA:
27.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
ALA A 541
GLU A 559
VAL A 572
MET A 591
GLY A 594
LEU A 656
None
0.59A 3ue4A-4f0iA:
31.2
3ue4A-4f0iA:
36.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
VAL A 523
ALA A 541
GLU A 559
VAL A 572
GLY A 594
LEU A 656
None
0.73A 3ue4B-4f0iA:
31.4
3ue4B-4f0iA:
36.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
VAL A 523
ALA A 541
LYS A 543
MET A 591
GLY A 594
LEU A 656
None
0.58A 3ug2A-4f0iA:
23.3
3ug2A-4f0iA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
ALA A 541
MET A 591
GLY A 594
ASP A 595
LEU A 656
GLY A 666
ASP A 667
None
0.54A 3zbfA-4f0iA:
31.7
3zbfA-4f0iA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 9 ILE A 571
MET A 586
TYR A 590
MET A 591
ILE A 665
None
0.56A 3zosA-4f0iA:
33.5
3zosA-4f0iA:
44.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 9 LEU A 515
ILE A 571
MET A 586
TYR A 590
MET A 591
ILE A 665
None
0.74A 3zosB-4f0iA:
33.5
3zosB-4f0iA:
44.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 9 LEU A 515
VAL A 523
ALA A 541
MET A 591
GLY A 594
LEU A 656
ASP A 667
None
0.61A 4anqA-4f0iA:
30.8
4anqA-4f0iA:
37.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 9 LEU A 515
VAL A 523
ALA A 541
MET A 591
GLY A 594
LEU A 656
ASP A 667
None
0.59A 4ansA-4f0iA:
30.8
4ansA-4f0iA:
37.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 5 VAL A 523
ILE A 571
TYR A 590
MET A 591
ILE A 665
None
0.48A 4c8bA-4f0iA:
26.4
4c8bA-4f0iA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
3 / 3 TYR A 590
MET A 591
ILE A 571
None
0.68A 4c8bB-4f0iA:
26.6
4c8bB-4f0iA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
3 / 3 TYR A 590
MET A 591
ILE A 665
None
0.41A 4c8bB-4f0iA:
26.6
4c8bB-4f0iA:
28.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 10 LEU A 515
GLY A 516
GLY A 518
VAL A 523
ALA A 541
TYR A 590
None
0.51A 4ckjA-4f0iA:
23.6
4ckjA-4f0iA:
38.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 12 LEU A 515
VAL A 523
ALA A 541
MET A 591
GLY A 594
LEU A 656
None
0.43A 4hjoA-4f0iA:
29.5
4hjoA-4f0iA:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
VAL A 523
ALA A 541
GLY A 594
ASP A 595
LEU A 656
ASP A 667
None
0.74A 4mkcA-4f0iA:
30.6
4mkcA-4f0iA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
ASP A 667
None
0.69A 4mxoA-4f0iA:
24.2
4mxoA-4f0iA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
VAL A 523
ALA A 541
LYS A 543
VAL A 572
GLY A 594
LEU A 656
ASP A 667
None
0.78A 4mxoB-4f0iA:
24.3
4mxoB-4f0iA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
LEU A 656
ASP A 667
None
0.72A 4mxoB-4f0iA:
24.3
4mxoB-4f0iA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
MET A 591
GLY A 594
LEU A 656
None
0.51A 4mxxB-4f0iA:
23.7
4mxxB-4f0iA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
VAL A 523
ALA A 541
LYS A 543
VAL A 572
TYR A 590
GLY A 594
LEU A 656
None
0.60A 4mxyA-4f0iA:
23.2
4mxyA-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
LEU A 656
ASP A 667
None
0.77A 4mxyA-4f0iA:
23.2
4mxyA-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
VAL A 523
ALA A 541
LYS A 543
VAL A 572
GLY A 594
LEU A 656
None
0.59A 4mxyB-4f0iA:
30.1
4mxyB-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
LEU A 656
ASP A 667
None
0.72A 4mxyB-4f0iA:
30.1
4mxyB-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
VAL A 523
ALA A 541
LYS A 543
VAL A 572
TYR A 590
GLY A 594
LEU A 656
None
0.60A 4mxzA-4f0iA:
23.2
4mxzA-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
LEU A 656
ASP A 667
None
0.77A 4mxzA-4f0iA:
23.2
4mxzA-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
VAL A 523
ALA A 541
LYS A 543
VAL A 572
GLY A 594
LEU A 656
None
0.59A 4mxzB-4f0iA:
30.1
4mxzB-4f0iA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 12 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
GLY A 594
LEU A 656
ASP A 667
None
0.72A 4mxzB-4f0iA:
30.1
4mxzB-4f0iA:
34.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 4 GLU A 614
GLY A 612
HIS A 593
ARG A 592
None
1.34A 4r82A-4f0iA:
undetectable
4r82B-4f0iA:
undetectable
4r82A-4f0iA:
19.00
4r82B-4f0iA:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 6 LEU A 515
VAL A 523
LYS A 543
ARG A 648
None
0.72A 4tyjA-4f0iA:
31.6
4tyjA-4f0iA:
39.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 6 VAL A 523
LYS A 543
ILE A 571
ARG A 648
ILE A 665
None
0.84A 4tyjA-4f0iA:
31.6
4tyjA-4f0iA:
39.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 10 LEU A 515
VAL A 523
LEU A 566
ILE A 571
VAL A 572
TYR A 590
ILE A 665
None
0.88A 4u0iA-4f0iA:
33.9
4u0iA-4f0iA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 10 VAL A 523
LEU A 566
ILE A 571
VAL A 572
TYR A 590
ARG A 648
ILE A 665
None
1.04A 4u0iA-4f0iA:
33.9
4u0iA-4f0iA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
9 / 11 LEU A 515
VAL A 523
ALA A 541
TYR A 590
MET A 591
GLY A 594
ASN A 654
LEU A 656
ASP A 667
None
0.77A 4u5jA-4f0iA:
24.5
4u5jA-4f0iA:
33.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 9 LEU A 515
VAL A 523
ALA A 541
TYR A 590
MET A 591
GLY A 594
LEU A 656
None
0.50A 4u5jB-4f0iA:
24.5
4u5jB-4f0iA:
33.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 9 LEU A 515
VAL A 523
LYS A 543
TYR A 590
ARG A 648
LEU A 656
ILE A 665
None
0.88A 4v01A-4f0iA:
26.5
4v01A-4f0iA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 9 LEU A 515
VAL A 523
TYR A 590
ARG A 648
LEU A 656
ILE A 665
None
0.92A 4v01B-4f0iA:
26.4
4v01B-4f0iA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 8 LYS A 543
ARG A 648
LEU A 656
ILE A 665
None
0.77A 4v04A-4f0iA:
25.8
4v04A-4f0iA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 10 LEU A 515
VAL A 523
LYS A 543
TYR A 590
LEU A 656
ILE A 665
None
0.87A 4v04B-4f0iA:
25.6
4v04B-4f0iA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 11 LEU A 515
ALA A 541
MET A 591
GLY A 594
ASN A 654
LEU A 656
None
0.44A 4wa9A-4f0iA:
27.5
4wa9A-4f0iA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 VAL A 523
ALA A 541
LYS A 543
MET A 591
GLY A 594
ASN A 654
LEU A 656
None
0.70A 4wa9B-4f0iA:
24.6
4wa9B-4f0iA:
36.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 6 LEU A 515
ALA A 541
MET A 591
LEU A 656
None
0.64A 4wboC-4f0iA:
16.2
4wboC-4f0iA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 LEU A 515
ALA A 541
VAL A 572
TYR A 590
MET A 591
GLY A 594
LEU A 656
None
0.60A 4xliA-4f0iA:
24.9
4xliA-4f0iA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 9 LEU A 515
VAL A 523
ALA A 541
MET A 591
GLY A 594
LEU A 656
GLY A 666
ASP A 667
None
0.59A 5aaaA-4f0iA:
31.2
5aaaA-4f0iA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 10 LEU A 515
VAL A 523
ALA A 541
MET A 591
GLY A 594
LEU A 656
GLY A 666
ASP A 667
None
0.59A 5aabA-4f0iA:
30.9
5aabA-4f0iA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
8 / 10 LEU A 515
VAL A 523
ALA A 541
MET A 591
GLY A 594
LEU A 656
GLY A 666
ASP A 667
None
0.65A 5aacA-4f0iA:
24.5
5aacA-4f0iA:
39.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 12 LEU A 515
VAL A 523
ALA A 541
GLY A 594
LEU A 656
GLY A 666
None
0.59A 5h2uA-4f0iA:
23.2
5h2uA-4f0iA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 12 LEU A 515
VAL A 523
ALA A 541
GLY A 594
LEU A 656
GLY A 666
None
0.58A 5h2uB-4f0iA:
29.2
5h2uB-4f0iA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 12 LEU A 515
ALA A 541
GLY A 594
LEU A 656
GLY A 666
None
0.51A 5h2uC-4f0iA:
23.3
5h2uC-4f0iA:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 12 LEU A 515
VAL A 523
ALA A 541
GLY A 594
LEU A 656
GLY A 666
None
0.56A 5h2uD-4f0iA:
29.2
5h2uD-4f0iA:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 6 GLY A 723
ASP A 649
ILE A 690
ARG A 691
None
0.90A 5iwuA-4f0iA:
4.2
5iwuA-4f0iA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 7 GLY A 516
GLY A 518
GLY A 521
VAL A 523
None
0.25A 5izjB-4f0iA:
15.0
5izjB-4f0iA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 GLY A 516
VAL A 523
ALA A 541
VAL A 572
PHE A 588
ASP A 595
LEU A 656
None
0.83A 5l2iA-4f0iA:
6.5
5l2iA-4f0iA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
7 / 12 GLY A 516
VAL A 523
ALA A 541
VAL A 572
PHE A 588
ASP A 595
LEU A 656
None
0.91A 5l2tA-4f0iA:
21.9
5l2tA-4f0iA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 10 LEU A 515
VAL A 523
ALA A 541
VAL A 572
TYR A 590
LEU A 656
None
0.80A 5n3hA-4f0iA:
15.0
5n3hA-4f0iA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 4 VAL A 523
LYS A 543
VAL A 572
ASN A 654
None
0.62A 5vc3A-4f0iA:
16.1
5vc3A-4f0iA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
6 / 12 LEU A 515
ALA A 541
LYS A 543
VAL A 572
GLY A 594
GLY A 666
None
1.03A 5vcvA-4f0iA:
15.6
5vcvA-4f0iA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
5 / 12 LEU A 515
GLY A 516
VAL A 523
ALA A 541
PHE A 588
None
0.25A 5xv7A-4f0iA:
20.1
5xv7A-4f0iA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 4 VAL A 572
GLY A 666
ASP A 667
ASP A 595
None
1.27A 6cjkC-4f0iA:
undetectable
6cjkC-4f0iA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo
sapiens)
4 / 6 THR A 704
PRO A 767
GLN A 768
ARG A 770
None
1.20A 6ef6A-4f0iA:
undetectable
6ef6A-4f0iA:
21.35