SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  74
SER A 142
MET A 143
THR A 271
HIS A 313
 SO4  A 402 ( 3.4A)
SO4  A 402 ( 2.4A)
None
EDO  A 407 ( 4.0A)
SO4  A 402 ( 3.6A)
 0.87A 1a8uA-4f0jA:
28.9		 1a8uA-4f0jA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 GLY A  74
SER A 142
MET A 143
THR A 271
HIS A 313
 SO4  A 402 ( 3.4A)
SO4  A 402 ( 2.4A)
None
EDO  A 407 ( 4.0A)
SO4  A 402 ( 3.6A)
 0.83A 1a8uB-4f0jA:
28.7		 1a8uB-4f0jA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 127
VAL A 133
GLY A 132
LEU A  43
TYR A  56
 None
 1.43A 1fkoA-4f0jA:
undetectable		 1fkoA-4f0jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 141
VAL A 165
THR A 271
LEU A 292
 EDO  A 408 ( 3.7A)
None
EDO  A 407 ( 4.0A)
None
 1.41A 1oq5A-4f0jA:
undetectable		 1oq5A-4f0jA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 ASP A 100
TRP A  82
GLY A 145
GLY A 144
SER A 142
 None
EDO  A 408 (-3.6A)
None
None
SO4  A 402 ( 2.4A)
 1.12A 1w76B-4f0jA:
12.9		 1w76B-4f0jA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 202
TYR A 206
TYR A 242
ILE A 245
 None
SO4  A 402 ( 4.3A)
None
None
 1.14A 2ph9A-4f0jA:
undetectable
2ph9B-4f0jA:
undetectable		 2ph9A-4f0jA:
19.20
2ph9B-4f0jA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  79
TYR A  36
MET A 221
HIS A  73
 None
 1.48A 2pncA-4f0jA:
undetectable		 2pncA-4f0jA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  37
LEU A  57
GLU A  83
ALA A  55
PHE A  34
 None
None
None
None
EDO  A 412 ( 4.9A)
 1.07A 3fl9A-4f0jA:
undetectable		 3fl9A-4f0jA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 243
LEU A 240
GLN A  48
 None
 0.56A 3g4lA-4f0jA:
undetectable		 3g4lA-4f0jA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 7 TYR A  56
VAL A 159
VAL A 133
ILE A  69
 None
 1.09A 3mssB-4f0jA:
undetectable		 3mssB-4f0jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 274
ILE A 245
ASP A 190
SER A 238
 EDO  A 405 (-3.3A)
None
None
None
 0.72A 3pwwA-4f0jA:
undetectable		 3pwwA-4f0jA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		4 / 6 TYR A  56
VAL A 159
VAL A 133
ILE A  69
 None
 0.99A 3pyyA-4f0jA:
undetectable		 3pyyA-4f0jA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		6 / 9 GLY A  93
ALA A  90
ASP A  91
ASP A  87
ILE A  86
ILE A  97
 None
 1.30A 3s53A-4f0jA:
undetectable		 3s53A-4f0jA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  71
ILE A 139
GLY A 140
GLY A 144
THR A 124
 None
 1.06A 4fakA-4f0jA:
undetectable		 4fakA-4f0jA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		6 / 9 LEU A 162
ALA A 148
LEU A 164
LEU A 254
LEU A 257
ALA A 152
 None
 0.97A 4z91F-4f0jA:
undetectable
4z91G-4f0jA:
undetectable
4z91H-4f0jA:
undetectable
4z91I-4f0jA:
undetectable
4z91J-4f0jA:
undetectable		 4z91F-4f0jA:
21.14
4z91G-4f0jA:
21.14
4z91H-4f0jA:
21.14
4z91I-4f0jA:
21.14
4z91J-4f0jA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		6 / 9 LEU A 254
LEU A 257
ALA A 152
LEU A 162
ALA A 148
LEU A 164
 None
 0.90A 4z91F-4f0jA:
undetectable
4z91G-4f0jA:
undetectable
4z91H-4f0jA:
undetectable
4z91I-4f0jA:
undetectable
4z91J-4f0jA:
undetectable		 4z91F-4f0jA:
21.14
4z91G-4f0jA:
21.14
4z91H-4f0jA:
21.14
4z91I-4f0jA:
21.14
4z91J-4f0jA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		6 / 9 LEU A 257
ALA A 152
LEU A 162
ALA A 148
LEU A 164
LEU A 254
 None
 0.86A 4z91F-4f0jA:
undetectable
4z91G-4f0jA:
undetectable
4z91H-4f0jA:
undetectable
4z91I-4f0jA:
undetectable
4z91J-4f0jA:
undetectable		 4z91F-4f0jA:
21.14
4z91G-4f0jA:
21.14
4z91H-4f0jA:
21.14
4z91I-4f0jA:
21.14
4z91J-4f0jA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		3 / 3 HIS A  73
LYS A  75
PHE A 104
 None
 1.48A 5klaA-4f0jA:
undetectable		 5klaA-4f0jA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  71
HIS A  73
ILE A 139
GLY A 140
GLY A 144
 None
 0.91A 5o96C-4f0jA:
undetectable
5o96D-4f0jA:
undetectable		 5o96C-4f0jA:
21.07
5o96D-4f0jA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4f0j PROBABLE HYDROLYTIC
ENZYME
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  88
LEU A  89
GLY A 330
LEU A 331
GLN A 332
 None
 1.26A 6czmE-4f0jA:
undetectable
6czmF-4f0jA:
undetectable		 6czmE-4f0jA:
23.21
6czmF-4f0jA:
23.21