SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  61
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.54A 1a4lA-4f0lA:
20.2		 1a4lA-4f0lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.35A 1a4lA-4f0lA:
20.2		 1a4lA-4f0lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.39A 1a4lB-4f0lA:
20.1		 1a4lB-4f0lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
PHE A  65
HIS A 237
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
None
FE  A 501 (-3.5A)
None
FE  A 501 (-2.8A)
 1.41A 1a4lB-4f0lA:
20.1		 1a4lB-4f0lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		6 / 12 HIS A  61
HIS A  63
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.57A 1a4lC-4f0lA:
20.0		 1a4lC-4f0lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.35A 1a4lD-4f0lA:
20.2		 1a4lD-4f0lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
PHE A  65
HIS A 237
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
None
FE  A 501 (-3.5A)
None
FE  A 501 (-2.8A)
 1.34A 1a4lD-4f0lA:
20.2		 1a4lD-4f0lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 TYR A 126
HIS A 212
HIS A 237
HIS A  61
ASP A 325
 None
None
FE  A 501 (-3.5A)
FE  A 501 (-3.4A)
FE  A 501 (-2.8A)
 1.12A 1ituA-4f0lA:
6.4		 1ituA-4f0lA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 TYR A 126
HIS A 212
HIS A 237
HIS A  61
ASP A 325
 None
None
FE  A 501 (-3.5A)
FE  A 501 (-3.4A)
FE  A 501 (-2.8A)
 1.12A 1ituB-4f0lA:
6.4		 1ituB-4f0lA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 383
ILE A  37
HIS A   8
GLY A  28
GLY A 426
 None
 1.11A 1zz1C-4f0lA:
undetectable		 1zz1C-4f0lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJY_H_BEZH306_0
(ANTIBODY 7A1 FAB')		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 4 ASN A 351
ALA A 349
ARG A 350
TYR A 341
 None
 1.27A 2ajyH-4f0lA:
undetectable		 2ajyH-4f0lA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AK1_H_BEZH401_0
(ANTIBODY 7A1 FAB')		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 4 ASN A 351
ALA A 349
ARG A 350
TYR A 341
 None
 1.31A 2ak1H-4f0lA:
0.0		 2ak1H-4f0lA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 336
GLY A 323
CYH A 271
ASN A  59
ALA A 375
 None
 1.28A 2bm9B-4f0lA:
undetectable		 2bm9B-4f0lA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 GLY A  20
LEU A  16
GLY A 367
ALA A 363
ALA A 354
 None
 1.07A 2bm9F-4f0lA:
undetectable		 2bm9F-4f0lA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 10 ALA A 149
ALA A 147
LEU A 199
LEU A 157
ALA A 205
 None
 1.06A 2bxeA-4f0lA:
undetectable		 2bxeA-4f0lA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 6 LEU A 303
HIS A  61
HIS A  63
HIS A 237
 None
FE  A 501 (-3.4A)
FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
 0.91A 2ow9A-4f0lA:
undetectable		 2ow9A-4f0lA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.34A 2pgfA-4f0lA:
21.5		 2pgfA-4f0lA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		6 / 12 HIS A  61
HIS A  63
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.46A 2pgrA-4f0lA:
21.6		 2pgrA-4f0lA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A 237
HIS A 274
GLY A 323
HIS A  61
HIS A  63
 FE  A 501 (-3.5A)
None
None
FE  A 501 (-3.4A)
FE  A 501 (-3.4A)
 1.12A 2pgrA-4f0lA:
21.6		 2pgrA-4f0lA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		3 / 3 SER A  51
ASP A 421
ASP A 395
 None
 0.66A 2plwA-4f0lA:
undetectable		 2plwA-4f0lA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		3 / 3 MET A 278
VAL A 238
GLU A 258
 None
 0.75A 3c6gA-4f0lA:
undetectable		 3c6gA-4f0lA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		6 / 12 ALA A 150
VAL A 209
ILE A 192
PHE A 188
HIS A 128
ALA A 143
 None
 1.49A 3cs9C-4f0lA:
undetectable		 3cs9C-4f0lA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		3 / 3 ASN A 327
MET A 142
PHE A  65
 None
 1.15A 3g4lD-4f0lA:
undetectable		 3g4lD-4f0lA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 11 HIS A  61
HIS A 274
GLU A 240
HIS A 237
THR A 299
 FE  A 501 (-3.4A)
None
None
FE  A 501 (-3.5A)
None
 1.34A 3iaiA-4f0lA:
undetectable		 3iaiA-4f0lA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 11 HIS A  61
HIS A 274
GLU A 240
HIS A 237
THR A 299
 FE  A 501 (-3.4A)
None
None
FE  A 501 (-3.5A)
None
 1.33A 3iaiB-4f0lA:
undetectable		 3iaiB-4f0lA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 11 HIS A  61
HIS A 274
GLU A 240
HIS A 237
THR A 299
 FE  A 501 (-3.4A)
None
None
FE  A 501 (-3.5A)
None
 1.33A 3iaiC-4f0lA:
undetectable		 3iaiC-4f0lA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 5 LEU A 303
HIS A  61
HIS A  63
HIS A 237
 None
FE  A 501 (-3.4A)
FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
 0.96A 3kecA-4f0lA:
undetectable		 3kecA-4f0lA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 10 GLY A 371
PHE A 320
GLY A 377
ILE A 273
CYH A 296
 None
FMT  A 502 (-4.2A)
None
None
None
 1.36A 3ko0L-4f0lA:
undetectable
3ko0N-4f0lA:
undetectable		 3ko0L-4f0lA:
12.98
3ko0N-4f0lA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 8 GLU A 240
TYR A  91
GLN A  66
ASP A 325
 None
None
None
FE  A 501 (-2.8A)
 1.19A 3mjrD-4f0lA:
undetectable		 3mjrD-4f0lA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 5 ALA A 149
GLU A 123
ALA A  64
MET A 113
 None
 1.42A 3r9tC-4f0lA:
undetectable		 3r9tC-4f0lA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 GLY A 122
VAL A 162
GLY A 372
ALA A 375
ALA A 293
 None
 0.94A 3sugA-4f0lA:
undetectable		 3sugA-4f0lA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 6 LEU A 303
HIS A  61
HIS A  63
HIS A 237
 None
FE  A 501 (-3.4A)
FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
 0.89A 4a7bA-4f0lA:
undetectable		 4a7bA-4f0lA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 5 LEU A  60
HIS A 235
HIS A 274
HIS A 237
 None
None
None
FE  A 501 (-3.5A)
 1.18A 4a7bB-4f0lA:
undetectable		 4a7bB-4f0lA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 GLN A  66
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 None
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.46A 4aqlA-4f0lA:
37.0		 4aqlA-4f0lA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 GLN A  66
HIS A 237
GLU A 244
HIS A 274
ASP A 325
 None
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.76A 4aqlA-4f0lA:
37.0		 4aqlA-4f0lA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 GLN A  66
LEU A 303
HIS A 237
GLU A 240
HIS A 274
 None
None
FE  A 501 (-3.5A)
None
None
 1.29A 4aqlA-4f0lA:
37.0		 4aqlA-4f0lA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		6 / 12 ARG A 436
GLY A 433
GLY A 432
LEU A 394
HIS A 435
VAL A 422
 None
 1.25A 4htfA-4f0lA:
undetectable		 4htfA-4f0lA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		6 / 12 ARG A 436
GLY A 433
GLY A 432
LEU A 394
HIS A 435
VAL A 422
 None
 1.26A 4htfB-4f0lA:
undetectable		 4htfB-4f0lA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 6 SER A 342
GLY A 323
ASP A 325
GLY A 294
 None
None
FE  A 501 (-2.8A)
None
 0.90A 4koeA-4f0lA:
undetectable
4koeB-4f0lA:
undetectable
4koeC-4f0lA:
undetectable		 4koeA-4f0lA:
22.64
4koeB-4f0lA:
22.64
4koeC-4f0lA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 7 SER A 342
GLY A 323
ASP A 325
GLY A 294
 None
None
FE  A 501 (-2.8A)
None
 0.91A 4koeA-4f0lA:
undetectable
4koeB-4f0lA:
undetectable
4koeD-4f0lA:
undetectable		 4koeA-4f0lA:
22.64
4koeB-4f0lA:
22.64
4koeD-4f0lA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 260
VAL A 266
HIS A 274
PHE A 124
GLY A 323
 None
 1.15A 4q15A-4f0lA:
undetectable		 4q15A-4f0lA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
HIS A 274
LEU A 303
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.49A 4r88A-4f0lA:
30.3		 4r88A-4f0lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
LEU A 303
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.48A 4r88B-4f0lA:
30.9		 4r88B-4f0lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
LEU A 303
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.47A 4r88C-4f0lA:
30.5		 4r88C-4f0lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A 237
GLU A 240
LEU A 303
ASP A 325
SER A 326
 FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
None
 1.03A 4r88C-4f0lA:
30.5		 4r88C-4f0lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
LEU A 303
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.48A 4r88D-4f0lA:
30.5		 4r88D-4f0lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
LEU A 303
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.50A 4r88E-4f0lA:
30.3		 4r88E-4f0lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
LEU A 303
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.49A 4r88F-4f0lA:
30.6		 4r88F-4f0lA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 295
LEU A 272
ALA A 275
ALA A 287
ALA A 291
 None
 0.93A 4x20B-4f0lA:
undetectable		 4x20B-4f0lA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 260
VAL A 266
HIS A 274
PHE A 124
GLY A 323
 None
 1.21A 4ydqA-4f0lA:
undetectable		 4ydqA-4f0lA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
HIS A  61
LEU A 160
ALA A 210
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
FE  A 501 (-3.4A)
None
None
 1.48A 4ygfG-4f0lA:
undetectable		 4ygfG-4f0lA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 6 GLY A 323
ASP A 325
GLY A 294
SER A 342
 None
FE  A 501 (-2.8A)
None
None
 0.89A 4z53A-4f0lA:
undetectable
4z53B-4f0lA:
undetectable		 4z53A-4f0lA:
21.75
4z53B-4f0lA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 7 GLY A 323
ASP A 325
GLY A 294
SER A 342
 None
FE  A 501 (-2.8A)
None
None
 0.91A 4z53A-4f0lA:
undetectable
4z53B-4f0lA:
undetectable		 4z53A-4f0lA:
21.75
4z53B-4f0lA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		6 / 9 LEU A 159
ALA A 147
LEU A 157
ALA A 150
ALA A 106
ALA A 143
 None
 1.23A 4z91F-4f0lA:
undetectable
4z91G-4f0lA:
undetectable
4z91H-4f0lA:
undetectable
4z91I-4f0lA:
undetectable
4z91J-4f0lA:
undetectable		 4z91F-4f0lA:
21.64
4z91G-4f0lA:
21.64
4z91H-4f0lA:
21.64
4z91I-4f0lA:
21.64
4z91J-4f0lA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 222
VAL A 234
GLY A 122
LEU A 159
THR A 158
 None
 1.10A 5byjA-4f0lA:
undetectable		 5byjA-4f0lA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		3 / 3 LEU A 272
PHE A 313
ILE A 292
 None
 0.75A 5dzk1-4f0lA:
undetectable
5dzkF-4f0lA:
1.6
5dzkM-4f0lA:
undetectable		 5dzk1-4f0lA:
9.52
5dzkF-4f0lA:
20.04
5dzkM-4f0lA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 4 LEU A 295
LEU A  60
GLY A 323
GLU A 335
 None
 1.26A 5hhjA-4f0lA:
undetectable		 5hhjA-4f0lA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_D_AZMD701_1
(CARBONIC ANHYDRASE 4)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 10 HIS A  61
HIS A 274
GLU A 240
HIS A 237
THR A 299
 FE  A 501 (-3.4A)
None
None
FE  A 501 (-3.5A)
None
 1.32A 5jn8D-4f0lA:
undetectable		 5jn8D-4f0lA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_1
(ENVELOPE
GLYCOPROTEIN,GP41)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 SER A 279
LYS A 284
GLU A 282
LEU A 261
GLU A 258
 None
 1.36A 5nvpA-4f0lA:
0.0		 5nvpA-4f0lA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 9 HIS A  63
HIS A 237
HIS A  61
LEU A 160
ALA A 210
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
FE  A 501 (-3.4A)
None
None
 1.45A 5tt3E-4f0lA:
undetectable		 5tt3E-4f0lA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 9 GLU A 300
LEU A 295
MET A  57
GLY A 367
LEU A 364
 None
 1.37A 5wgqA-4f0lA:
undetectable		 5wgqA-4f0lA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 260
VAL A 266
HIS A 274
PHE A 124
GLY A 323
 None
 1.17A 5xipA-4f0lA:
undetectable		 5xipA-4f0lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 260
VAL A 266
HIS A 274
PHE A 124
GLY A 323
 None
 1.24A 5xipC-4f0lA:
undetectable		 5xipC-4f0lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 260
VAL A 266
HIS A 274
PHE A 124
GLY A 323
 None
 1.18A 5xiqA-4f0lA:
undetectable		 5xiqA-4f0lA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 LEU A 260
VAL A 266
HIS A 274
PHE A 124
GLY A 323
 None
 1.14A 5xiqD-4f0lA:
undetectable		 5xiqD-4f0lA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		3 / 3 PHE A  83
ARG A  87
GLN A 241
 None
 1.00A 6g1pB-4f0lA:
undetectable		 6g1pB-4f0lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		4 / 8 VAL A 121
TYR A 110
HIS A  63
TYR A  67
 None
None
FE  A 501 (-3.4A)
None
 1.27A 6gneB-4f0lA:
undetectable		 6gneB-4f0lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.36A 6n91A-4f0lA:
21.1		 6n91A-4f0lA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
HIS A 237
GLU A 240
HIS A 274
ASP A 325
 FE  A 501 (-3.4A)
FE  A 501 (-3.5A)
None
None
FE  A 501 (-2.8A)
 0.37A 6n91B-4f0lA:
20.7		 6n91B-4f0lA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 4f0l AMIDOHYDROLASE
(Brucella
abortus) 		5 / 12 HIS A  63
LEU A 303
HIS A 237
GLU A 240
HIS A 274
 FE  A 501 (-3.4A)
None
FE  A 501 (-3.5A)
None
None
 1.27A 6n91B-4f0lA:
20.7		 6n91B-4f0lA:
10.13