SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803;
Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A 101
ASP B   3
LEU A   5
TYR A 165
THR B   6
 None
 1.26A 1jomA-4f0tA:
undetectable		 1jomA-4f0tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 101
ASP B   3
LEU A   5
TYR A 165
THR B   6
 None
 1.29A 1rb3A-4f0tA:
undetectable		 1rb3A-4f0tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 ALA A 101
ASP B   3
LEU A   5
TYR A 165
THR B   6
 None
 1.35A 1tdrB-4f0tA:
undetectable		 1tdrB-4f0tA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 ALA A 101
ASP B   3
LEU A   5
TYR A 165
THR B   6
 None
 1.23A 2oipC-4f0tA:
undetectable		 2oipC-4f0tA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A  17
ASN B  47
THR B  96
 None
 0.87A 2q63A-4f0tA:
undetectable		 2q63A-4f0tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 THR B  45
ALA B  98
THR B 101
VAL A   9
GLN A  15
 None
 1.10A 2ve3A-4f0tB:
undetectable		 2ve3A-4f0tB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A  51
LEU A  44
SER A 145
LEU A 144
LEU A 166
 None
 1.00A 2xn5A-4f0tA:
undetectable		 2xn5A-4f0tA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLU A   7
ASP A 108
TYR A 168
 None
 0.77A 2yvlB-4f0tA:
undetectable		 2yvlB-4f0tA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gB-4f0tB:
undetectable		 3j6gB-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gD-4f0tB:
undetectable		 3j6gD-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gF-4f0tB:
undetectable		 3j6gF-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gH-4f0tB:
0.7		 3j6gH-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gJ-4f0tB:
undetectable		 3j6gJ-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gL-4f0tB:
undetectable		 3j6gL-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gN-4f0tB:
undetectable		 3j6gN-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gP-4f0tB:
undetectable		 3j6gP-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL B   9
ASP B  13
LEU B  24
GLN A  49
LEU A  92
 None
 1.33A 3j6gR-4f0tB:
undetectable		 3j6gR-4f0tB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A 115
ASN A 171
TYR A 168
ILE A 112
ALA A 113
 None
 1.24A 3u6tA-4f0tA:
undetectable		 3u6tA-4f0tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A 115
SER A 174
ASN A 171
TYR A 168
ILE A 112
 None
 1.28A 3u6tA-4f0tA:
undetectable		 3u6tA-4f0tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4f0t C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		3 / 3 LYS B  75
TYR B  76
ARG B  80
 MEN  B  72 (-3.4A)
None
MEN  B  72 (-4.5A)
 1.46A 4gc9A-4f0tB:
undetectable		 4gc9A-4f0tB:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803;
Synechocystis
sp.
PCC
6803) 		5 / 11 ALA A 101
ASP B   3
LEU A   5
TYR A 165
THR B   6
 None
 1.25A 4i1nA-4f0tA:
undetectable		 4i1nA-4f0tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803;
Synechocystis
sp.
PCC
6803) 		5 / 12 LEU B  19
LEU B  27
SER B  28
LEU A  38
VAL A 100
 None
 1.15A 5twjC-4f0tB:
undetectable		 5twjC-4f0tB:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A  50
VAL A  52
ALA A  58
ALA A  55
GLY A  54
 None
 1.37A 5tzoA-4f0tA:
undetectable		 5tzoA-4f0tA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A  50
VAL A  52
ALA A  58
ALA A  55
GLY A  54
 None
 1.31A 5tzoC-4f0tA:
undetectable		 5tzoC-4f0tA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803) 		4 / 7 VAL A  52
ARG A  93
TYR B  18
LEU A 107
 None
 1.18A 5umwB-4f0tA:
undetectable
5umwE-4f0tA:
undetectable		 5umwB-4f0tA:
17.65
5umwE-4f0tA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 4f0t C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN
(Synechocystis
sp.
PCC
6803;
Synechocystis
sp.
PCC
6803) 		4 / 4 SER B  10
THR A   6
ASP A  13
ASP B 103
 None
 1.49A 5vimB-4f0tB:
undetectable		 5vimB-4f0tB:
20.51